Protein name:
Cytoplasmic tyrosine-protein kinase BMX ;
Alternative:
Epithelial and endothelial tyrosine kinase (ETK) ;Bone marrow tyrosine kinase gene in chromosome X protein ;NTK38 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with BCAR1, CAV1, MYD88, PTK2, RUFY1, RUFY2, STAT3, TIRAP and TNFRSF1B.
Function:
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
Subcellular Location:
Cytoplasm
Localizes to the edges of spreading cells when complexed with BCAR1.
Protein Attributes:
50:
MDTKSILEEL | LLKRSQQKKK | MSPNNYKERL | FVLTKTNLSY | YEYDKMKRGS |
100:
RKGSIEIKKI | RCVEKVNLEE | QTPVERQYPF | QIVYKDGLLY | VYASNEESRS |
150:
QWLKALQKEI | RGNPHLLVKY | HSGFFVDGKF | LCCQQSCKAA | PGCTLWEAYA |
200:
NLHTAVNEEK | HRVPTFPDRV | LKIPRAVPVL | KMDAPSSSTT | LAQYDNESKK |
250:
NYGSQPPSSS | TSLAQYDSNS | KKIYGSQPNF | NMQYIPREDF | PDWWQVRKLK |
300:
SSSSSEDVAS | SNQKERNVNH | TTSKISWEFP | ESSSSEEEEN | LDDYDWFAGN |
350:
ISRSQSEQLL | RQKGKEGAFM | VRNSSQVGMY | TVSLFSKAVN | DKKGTVKHYH |
400:
VHTNAENKLY | LAENYCFDSI | PKLIHYHQHN | SAGMITRLRH | PVSTKANKVP |
450:
DSVSLGNGIW | ELKREEITLL | KELGSGQFGV | VQLGKWKGQY | DVAVKMIKEG |
500:
SMSEDEFFQE | AQTMMKLSHP | KLVKFYGVCS | KEYPIYIVTE | YISNGCLLNY |
550:
LRSHGKGLEP | SQLLEMCYDV | CEGMAFLESH | QFIHRDLAAR | NCLVDRDLCV |
600:
KVSDFGMTRY | VLDDQYVSSV | GTKFPVKWSA | PEVFHYFKYS | SKSDVWAFGI |
650:
LMWEVFSLGK | QPYDLYDNSQ | VVLKVSQGHR | LYRPHLASDT | IYQIMYSCWH |
675:
ELPEKRPTFQ | QLLSSIEPLR | EKDKH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Cytoplasmic tyrosine-protein kinase BMX
ELISA Kit for Human Cytoplasmic tyrosine-protein kinase BMX
CLIA Kit for Human Cytoplasmic tyrosine-protein kinase BMX
CLIA Kit for Human Cytoplasmic tyrosine-protein kinase BMX
Polyclonal Antibody for Human Cytoplasmic tyrosine-protein kinase BMX
Polyclonal Antibody for Human Cytoplasmic tyrosine-protein kinase BMX
Monoclonal Antibody for Human Cytoplasmic tyrosine-protein kinase BMX
Monoclonal Antibody for Human Cytoplasmic tyrosine-protein kinase BMX
Protein for Human Cytoplasmic tyrosine-protein kinase BMX
Protein for Human Cytoplasmic tyrosine-protein kinase BMX
R&D Technical Data
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Precision
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Recovery
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Linearity
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Bone marrow .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INDUCTION
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Skin .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 207-220 AND 223-236;PHOSPHORYLATION AT TYR-216 AND TYR-224
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 536-599
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Blood .
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Mol. Cell. Biol.20:2043-2054(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-566;MUTAGENESIS OF TYR-566;FUNCTION;INTERACTION WITH STAT3
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION;INTERACTION WITH PTK2/FAK1;ENZYME REGULATION;FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DOMAIN;INTERACTION WITH CAV1
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RUFY1 AND RUFY2
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ENZYME REGULATION;PHOSPHORYLATION;FUNCTION;INTERACTION WITH TNFRSF1B
13.
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Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BCAR1
14.
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Cited for : FUNCTION
15.
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Cited for : PHOSPHORYLATION;ENZYME REGULATION;FUNCTION;INTERACTION WITH MYD88; PTK2/FAK1 AND TIRAP
16.
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Cited for : REVIEW ON FUNCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION
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20.
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Cited for : STRUCTURE BY NMR OF 291-393
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Nature446:153-158(2007)
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[
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Cited for : VARIANTS [LARGE SCALE ANALYSIS] LEU-284 AND TRP-670