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Index > Protein center > BMX(Gene name) > Human
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  • BMX (Gene name),
  • Cytoplasmic tyrosine-protein kinase BMX (Protein name ),  BMX_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    BMX;
    Protein name:
    Cytoplasmic tyrosine-protein kinase BMX;
    Alternative:
    Epithelial and endothelial tyrosine kinase(ETK);Bone marrow tyrosine kinase gene in chromosome X protein;NTK38;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with BCAR1, CAV1, MYD88, PTK2, RUFY1, RUFY2, STAT3, TIRAP and TNFRSF1B.
    Function:
    Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a role in programming adaptive cytoprotection against extracellular stress in different cell systems, salivary epithelial cells, brain endothelial cells, and dermal fibroblasts. May be involved in regulation of endocytosis through its interaction with an endosomal protein RUFY1. May also play a role in the growth and differentiation of hematopoietic cells; as well as in signal transduction in endocardial and arterial endothelial cells.
    Subcellular Location:
    Cytoplasm Localizes to the edges of spreading cells when complexed with BCAR1.
    Protein Attributes:
    Sequence length:
    675
    Sequence:
    50:
    MDTKSILEEL | LLKRSQQKKK | MSPNNYKERL | FVLTKTNLSY | YEYDKMKRGS | 
    100:
    RKGSIEIKKI | RCVEKVNLEE | QTPVERQYPF | QIVYKDGLLY | VYASNEESRS | 
    150:
    QWLKALQKEI | RGNPHLLVKY | HSGFFVDGKF | LCCQQSCKAA | PGCTLWEAYA | 
    200:
    NLHTAVNEEK | HRVPTFPDRV | LKIPRAVPVL | KMDAPSSSTT | LAQYDNESKK | 
    250:
    NYGSQPPSSS | TSLAQYDSNS | KKIYGSQPNF | NMQYIPREDF | PDWWQVRKLK | 
    300:
    SSSSSEDVAS | SNQKERNVNH | TTSKISWEFP | ESSSSEEEEN | LDDYDWFAGN | 
    350:
    ISRSQSEQLL | RQKGKEGAFM | VRNSSQVGMY | TVSLFSKAVN | DKKGTVKHYH | 
    400:
    VHTNAENKLY | LAENYCFDSI | PKLIHYHQHN | SAGMITRLRH | PVSTKANKVP | 
    450:
    DSVSLGNGIW | ELKREEITLL | KELGSGQFGV | VQLGKWKGQY | DVAVKMIKEG | 
    500:
    SMSEDEFFQE | AQTMMKLSHP | KLVKFYGVCS | KEYPIYIVTE | YISNGCLLNY | 
    550:
    LRSHGKGLEP | SQLLEMCYDV | CEGMAFLESH | QFIHRDLAAR | NCLVDRDLCV | 
    600:
    KVSDFGMTRY | VLDDQYVSSV | GTKFPVKWSA | PEVFHYFKYS | SKSDVWAFGI | 
    650:
    LMWEVFSLGK | QPYDLYDNSQ | VVLKVSQGHR | LYRPHLASDT | IYQIMYSCWH | 
    675:
    ELPEKRPTFQ | QLLSSIEPLR | EKDKH
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    MIM:
    String:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cytoplasmic tyrosine-protein kinase BMX
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    E2227h
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    96T
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    ELISA Kit for Human Cytoplasmic tyrosine-protein kinase BMX
    Cat.:
    E2227m
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    Packing:
    96T
    CLIA Kit for Human Cytoplasmic tyrosine-protein kinase BMX
    Cat.:
    U2227m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Cytoplasmic tyrosine-protein kinase BMX
    Cat.:
    U2227h
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    Packing:
    96T
    Polyclonal Antibody for Human Cytoplasmic tyrosine-protein kinase BMX
    Cat.:
    P2227Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cytoplasmic tyrosine-protein kinase BMX
    Cat.:
    P2227Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cytoplasmic tyrosine-protein kinase BMX
    Monoclonal Antibody for Human Cytoplasmic tyrosine-protein kinase BMX
    Protein for Human Cytoplasmic tyrosine-protein kinase BMX
    Protein for Human Cytoplasmic tyrosine-protein kinase BMX

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2."
      Tamagnone L. , Lahtinen I. , Mustonen T. , Virtaneva K. , Francis F. , Muscatelli F. , Alitalo R.P. , Smith C.I. , Larsson C. , Alitalo K.
      Oncogene9:3683-3688(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Bone marrow.
    2. 2.
      "Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells."
      Qiu Y. , Robinson D. , Pretlow T. , Kung H.-J.
      Proc. Natl. Acad. Sci. U.S.A.95:3644-3649(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INDUCTION
      tissue: Prostate.
    3. 3.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skin.
    6. 6.
      "Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases."
      Nore B.F. , Mattsson P.T. , Antonsson P. , Backesjo C.-M. , Westlund A. , Lennartsson J. , Hansson H. , Low P. , Ronnstrand L. , Smith C.I.E.
      Biochim. Biophys. Acta1645:123-132(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 207-220 AND 223-236;PHOSPHORYLATION AT TYR-216 AND TYR-224
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 536-599
      tissue: Blood.
    8. 8.
      "Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation."
      Tsai Y.T. , Su Y.H. , Fang S.S. , Huang T.N. , Qiu Y. , Jou Y.S. , Shih H.M. , Kung H.J. , Chen R.H.
      Mol. Cell. Biol.20:2043-2054(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-566;MUTAGENESIS OF TYR-566;FUNCTION;INTERACTION WITH STAT3
    9. 9.
      "Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain."
      Chen R. , Kim O. , Li M. , Xiong X. , Guan J.L. , Kung H.J. , Chen H. , Shimizu Y. , Qiu Y.
      Nat. Cell Biol.3:439-444(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;INTERACTION WITH PTK2/FAK1;ENZYME REGULATION;FUNCTION
    10. 10.
      "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx."
      Vargas L. , Nore B.F. , Berglof A. , Heinonen J.E. , Mattsson P.T. , Smith C.I. , Mohamed A.J.
      J. Biol. Chem.277:9351-9357(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN;INTERACTION WITH CAV1
    11. 11.
      "Interaction between tyrosine kinase Etk and a RUN-domain and FYVE-domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking."
      Yang J. , Kim O. , Wu J. , Qiu Y.
      J. Biol. Chem.277:30219-30226(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RUFY1 AND RUFY2
    12. 12.
      "Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis."
      Pan S. , An P. , Zhang R. , He X. , Yin G. , Min W.
      Mol. Cell. Biol.22:7512-7523(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION;PHOSPHORYLATION;FUNCTION;INTERACTION WITH TNFRSF1B
    13. 13.
      "p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration."
      Abassi Y.A. , Rehn M. , Ekman N. , Alitalo K. , Vuori K.
      J. Biol. Chem.278:35636-35643(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BCAR1
    14. 14.
      "Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems."
      Chau C.H. , Clavijo C.A. , Deng H.T. , Zhang Q. , Kim K.J. , Qiu Y. , Le A.D. , Ann D.K.
      Am. J. Physiol.289:C444-C454(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    15. 15.
      "Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways."
      Semaan N. , Alsaleh G. , Gottenberg J.E. , Wachsmann D. , Sibilia J.
      J. Immunol.180:3485-3491(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;ENZYME REGULATION;FUNCTION;INTERACTION WITH MYD88; PTK2/FAK1 AND TIRAP
    16. 16.
      "Signaling network of the Btk family kinases."
      Qiu Y. , Kung H.J.
      Oncogene19:5651-5661(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    17. 17.
      "The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species."
      Smith C.I. , Islam T.C. , Mattsson P.T. , Mohamed A.J. , Nore B.F. , Vihinen M.
      Bioessays23:436-446(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
    19. 19.
      "Solution structure of the human BMX SH2 domain and of the BTK motif of human cytoplasmic tyrosine-protein kinase BMX."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2007-10) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 112-393
    20. 20.
      "Solution structure of the human bmx SH2 domain."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2009-02) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 291-393
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