BRCA1 ELISA Kit for Human(Homo sapiens) | EIAab.comBRCA1 ELISA Kit for Human(Homo sapiens)

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BRCA1 (Gene name),

Breast cancer type 1 susceptibility protein (Protein name ), BRCA1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

BRCA1(RNF53);

Protein name:

Breast cancer type 1 susceptibility protein;

Alternative:

RING finger protein 53;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the RAD50-MRE11-NBN protein complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. Interacts (via BRCT domains) with FAM175A/Abraxas and RBBP8. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A and COBRA1/NELFB. Interacts (via BRCT domains) with phosphorylated BRIP1. Interacts with FANCD2 (ubiquitinated). Interacts with BAP1. Interacts with DCLRE1C/Artemis and CLSPN. Interacts with H2AFX (phosphorylated on 'Ser-140'). Interacts with CHEK1/CHK1. Interacts with BRCC3. Interacts (via BRCT domains) with ACACA (phosphorylated); the interaction prevents dephosphorylation of ACACA. Interacts with AURKA. Interacts with UBXN1. Part of a trimeric complex containing BRCA1, BRCA2 and PALB2. Interacts with PALB2 and this interaction is essential for its function in HRR. Interacts with BRCA2 only in the presence of PALB2 which serves as the bridging protein.

Function:

E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks.

Subcellular Location:

Isoform 5 Cytoplasm

Protein Attributes:

Sequence length:

1863

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1863:

DTYLIPQIPH | SHY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P38398

MIM:

113705

STRING:

9606.ENSP00000350283

SMR:

P38398

Pfam:

PF00533

KEGG:

hsa:672

UniGene:

Hs.194143

Uniprot:

P38398

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ELISA Kit for Human Breast cancer type 1 susceptibility protein

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E0939h

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96T

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ELISA Kit for Human Breast cancer type 1 susceptibility protein

Cat.:

E0939b

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96T

ELISA Kit for Human Breast cancer type 1 susceptibility protein

Cat.:

E0939d

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96T

ELISA Kit for Human Breast cancer type 1 susceptibility protein

Cat.:

E0939m

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96T

ELISA Kit for Human Breast cancer type 1 susceptibility protein

Cat.:

E0939r

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96T

CLIA Kit for Human Breast cancer type 1 susceptibility protein

Cat.:

U0939d

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96T

CLIA Kit for Human Breast cancer type 1 susceptibility protein

Cat.:

U0939r

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96T

CLIA Kit for Human Breast cancer type 1 susceptibility protein

Cat.:

U0939b

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96T

CLIA Kit for Human Breast cancer type 1 susceptibility protein

Cat.:

U0939h

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human Breast cancer type 1 susceptibility protein

Cat.:

U0939m

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96T

Polyclonal Antibody for Human Breast cancer type 1 susceptibility protein

Cat.:

P0939Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Breast cancer type 1 susceptibility protein

Cat.:

P0939Rb-r

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Polyclonal Antibody for Human Breast cancer type 1 susceptibility protein

Cat.:

P0939Rb-h

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Monoclonal Antibody for Human Breast cancer type 1 susceptibility protein

Protein for Human Breast cancer type 1 susceptibility protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1."
Miki Y. , Swensen J. , Shattuck-Eidens D. , Futreal P.A. , Harshman K. , Tavtigian S. , Liu Q. , Cochran C. , Bennett L.M. , Ding W. , Bell R. , Rosenthal J. , Hussey C. , Tran T. , McClure M. , Frye C. , Hattier T. , Phelps R. , more...
Science266:66-71(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT BC ARG-1775
2.

"Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1."
Smith T.M. , Lee M.K. , Szabo C.I. , Jerome N. , McEuen M. , Taylor M. , Hood L. , King M.-C.
Genome Res.6:1029-1049(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Differential subcellular localization, expression and biological toxicity of BRCA1 and the splice variant BRCA1-delta11b."
Wilson C.A. , Payton M.N. , Elliott G.S. , Buaas F.W. , Cajulis E.E. , Grosshans D. , Ramos L. , Reese D.M. , Slamon D.J. , Calzone F.J.
Oncogene14:1-16(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);SUBCELLULAR LOCATION (ISOFORM 2);VARIANTS ARG-239 AND GLY-1613;TISSUE SPECIFICITY (ISOFORMS 1 AND 3)
tissue: Mammary gland.
4.

Holt J.T. , Robinson-Benion C.
Submitted (1997-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Testis.
5.

Raymond C.K. , Paddock M. , Subramanian S. , Deodato C. , Zhou Y. , Haugen E. , Kaul R. , Olson M.V.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ARG-356
6.

NIEHS SNPs program
Submitted (2003-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-275; ARG-356; ASN-693; LEU-871; GLY-1038; ASN-1040; GLY-1140; ARG-1183; GLY-1613 AND ALA-1620
7.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6 AND 7);VARIANTS LEU-871; GLY-1038; ARG-1183; GLY-1613 AND ILE-1652
tissue: PNS.
9.

"Initiation of translation from a downstream in-frame AUG codon on BRCA1 can generate the novel isoform protein DeltaBRCA1(17aa)."
Liu J. , Prolla G. , Rostagno A. , Chiarle R. , Feiner H. , Inghirami G.
Oncogene19:2767-2773(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 6-18 (ISOFORM 1);PROTEIN SEQUENCE OF 18-26 (ISOFORM 4);ALTERNATIVE INITIATION (ISOFORM 4)
10.

"Localization of BRCA1 and a splice variant identifies the nuclear localization signal."
Thakur S. , Zhang H.B. , Peng Y. , Le H. , Carroll B. , Ward T. , Yao J. , Farid L.M. , Couch F.J. , Wilson R.B. , Weber B.L.
Mol. Cell. Biol.17:444-452(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 5);SUBCELLULAR LOCATION (ISOFORM 5)
11.

"BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression."
Jensen D.E. , Proctor M. , Marquis S.T. , Gardner H.P. , Ha S.I. , Chodosh L.A. , Ishov A.M. , Tommerup N. , Vissing H. , Sekido Y. , Minna J. , Borodovsky A. , Schultz D.C. , Wilkinson K.D. , Maul G.G. , Barlev N. , Berger S. , Prendergast G.C. , more...
Oncogene16:1097-1112(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAP1;SUBCELLULAR LOCATION;VARIANTS GLY-61 AND GLY-64;MUTAGENESIS OF ARG-71
12.

"Characterization of a carboxy-terminal BRCA1 interacting protein."
Wong A.K. , Ormonde P.A. , Pero R. , Chen Y. , Lian L. , Salada G. , Berry S. , Lawrence Q. , Dayananth P. , Ha P. , Tavtigian S.V. , Teng D.H. , Bartel P.L.
Oncogene17:2279-2285(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RBBP8
13.

"RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination."
Lorick K.L. , Jensen J.P. , Fang S. , Ong A.M. , Hatakeyama S. , Weissman A.M.
Proc. Natl. Acad. Sci. U.S.A.96:11364-11369(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN E2-DEPENDENT UBIQUITIN-PROTEIN LIGASE
14.

"BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures."
Wang Y. , Cortez D. , Yazdi P. , Neff N. , Elledge S.J. , Qin J.
Genes Dev.14:927-939(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BASC COMPLEX
15.

"Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress."
Tibbetts R.S. , Cortez D. , Brumbaugh K.M. , Scully R. , Livingston D. , Elledge S.J. , Abraham R.T.
Genes Dev.14:2989-3002(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-1143; SER-1280; SER-1387; THR-1394; SER-1423 AND SER-1457;MUTAGENESIS OF SER-1143; SER-1239; SER-1280; SER-1298; SER-1330; SER-1387; THR-1394; SER-1423; SER-1457; SER-1466; SER-1524 AND SER-1755;CHARACTERIZATION OF VARIANT BC ALA-1720
16.

"hCds1-mediated phosphorylation of BRCA1 regulates the DNA damage response."
Lee J.S. , Collins K.M. , Brown A.L. , Lee C.H. , Chung J.H.
Nature404:201-204(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DNA DAMAGE RESPONSE;PHOSPHORYLATION AT SER-988 BY CHEK2;INTERACTION WITH CHEK2
17.

"BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function."
Cantor S.B. , Bell D.W. , Ganesan S. , Kass E.M. , Drapkin R. , Grossman S. , Wahrer D.C.R. , Sgroi D.C. , Lane W.S. , Haber D.A. , Livingston D.M.
Cell105:149-160(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BRIP1;CHARACTERIZATION OF VARIANT OVARIAN CANCER ARG-1749;CHARACTERIZATION OF VARIANT BC ARG-1775
18.

"BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations."
Ye Q. , Hu Y.-F. , Zhong H. , Nye A.C. , Belmont A.S. , Li R.
J. Cell Biol.155:911-921(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NELFB
19.

"Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway."
Garcia-Higuera I. , Taniguchi T. , Ganesan S. , Meyn M.S. , Timmers C. , Hejna J. , Grompe M. , D'Andrea A.D.
Mol. Cell7:249-262(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FANCD2
20.

"Phosphorylation of serine 1387 in BRCA1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation."
Xu B. , O'Donnell A.H. , Kim S.-T. , Kastan M.B.
Cancer Res.62:4588-4591(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ATM;MUTAGENESIS OF SER-1387; SER-1423 AND SER-1524
21.

"NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain."
Kobayashi J. , Tauchi H. , Sakamoto S. , Nakamura A. , Morishima K. , Matsuura S. , Kobayashi T. , Tamai K. , Tanimoto K. , Komatsu K.
Curr. Biol.12:1846-1851(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH H2AFX
22.

"SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint."
Yazdi P.T. , Wang Y. , Zhao S. , Patel N. , Lee E.Y.-H.P. , Qin J.
Genes Dev.16:571-582(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMC1A
23.

"The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity."
Sum E.Y. , Peng B. , Yu X. , Chen J. , Byrne J. , Lindeman G.J. , Visvader J.E.
J. Biol. Chem.277:7849-7856(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LMO4
24.

"BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage."
Yarden R.I. , Pardo-Reoyo S. , Sgagias M. , Cowan K.H. , Brody L.C.
Nat. Genet.30:285-289(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CHEK1
25.

"BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains."
Magnard C. , Bachelier R. , Vincent A. , Jaquinod M. , Kieffer S. , Lenoir G.M. , Venezia N.D.
Oncogene21:6729-6739(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACACA
26.

"The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin."
Wu-Baer F. , Lagrazon K. , Yuan W. , Baer R.
J. Biol. Chem.278:34743-34746(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;UBIQUITINATION;INTERACTION WITH BARD1
27.

"BRCA1-independent ubiquitination of FANCD2."
Vandenberg C.J. , Gergely F. , Ong C.Y. , Pace P. , Mallery D.L. , Hiom K. , Patel K.J.
Mol. Cell12:247-254(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
28.

"Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair."
Dong Y. , Hakimi M.-A. , Chen X. , Kumaraswamy E. , Cooch N.S. , Godwin A.K. , Shiekhattar R.
Mol. Cell12:1087-1099(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BRCC3
29.

"BRCA1:BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair."
Morris J.R. , Solomon E.
Hum. Mol. Genet.13:807-817(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BARD1
30.

"BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition."
Ouchi M. , Fujiuchi N. , Sasai K. , Katayama H. , Minamishima Y.A. , Ongusaha P.P. , Deng C. , Sen S. , Lee S.W. , Ouchi T.
J. Biol. Chem.279:19643-19648(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AURKA;FUNCTION;MUTAGENESIS OF SER-308;PHOSPHORYLATION AT SER-308
31.

"Artemis is a phosphorylation target of ATM and ATR and is involved in the G2/M DNA damage checkpoint response."
Zhang X. , Succi J. , Feng Z. , Prithivirajsingh S. , Story M.D. , Legerski R.J.
Mol. Cell. Biol.24:9207-9220(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DCLRE1C
32.

"Human claspin works with BRCA1 to both positively and negatively regulate cell proliferation."
Lin S.-Y. , Li K. , Stewart G.S. , Elledge S.J.
Proc. Natl. Acad. Sci. U.S.A.101:6484-6489(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CLSPN
33.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1336;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
34.

"BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP."
Yu X. , Fu S. , Lai M. , Baer R. , Chen J.
Genes Dev.20:1721-1726(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH RBBP8;MUTAGENESIS OF ILE-26
35.

"BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase."
Moreau K. , Dizin E. , Ray H. , Luquain C. , Lefai E. , Foufelle F. , Billaud M. , Lenoir G.M. , Venezia N.D.
J. Biol. Chem.281:3172-3181(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH ACACA
36.

"ACCA phosphopeptide recognition by the BRCT repeats of BRCA1."
Ray H. , Moreau K. , Dizin E. , Callebaut I. , Venezia N.D.
J. Mol. Biol.359:973-982(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ACACA
37.

"Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation."
Sankaran S. , Crone D.E. , Palazzo R.E. , Parvin J.D.
Cancer Res.67:11186-11194(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION BY AURKA;ENZYME REGULATION
38.

"CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response."
Kim H. , Huang J. , Chen J.
Nat. Struct. Mol. Biol.14:710-715(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FAM175A
39.

"CCDC98 targets BRCA1 to DNA damage sites."
Liu Z. , Wu J. , Yu X.
Nat. Struct. Mol. Biol.14:716-720(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FAM175A
40.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
41.

"Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response."
Wang B. , Matsuoka S. , Ballif B.A. , Zhang D. , Smogorzewska A. , Giyi S. , Elledge S.J.
Science316:1194-1198(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH FAM175A
42.

"Germline BRCA1 mutations predispose to pancreatic adenocarcinoma."
Al-Sukhni W. , Rothenmund H. , Borgida A.E. , Zogopoulos G. , O'Shea A.M. , Pollett A. , Gallinger S.
Hum. Genet.124:271-278(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PNCA4
43.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-395; SER-398; SER-753; SER-1211; SER-1217 AND SER-1218;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
44.

"MERIT40 facilitates BRCA1 localization and DNA damage repair."
Feng L. , Huang J. , Chen J.
Genes Dev.23:719-728(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE BRCA1-A COMPLEX
45.

"NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control."
Wang B. , Hurov K. , Hofmann K. , Elledge S.J.
Genes Dev.23:729-739(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BRCA1-A COMPLEX
46.

"MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks."
Shao G. , Patterson-Fortin J. , Messick T.E. , Feng D. , Shanbhag N. , Wang Y. , Greenberg R.A.
Genes Dev.23:740-754(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BRCA1-A COMPLEX
47.

"PALB2 is an integral component of the BRCA complex required for homologous recombination repair."
Sy S.M. , Huen M.S. , Chen J.
Proc. Natl. Acad. Sci. U.S.A.106:7155-7160(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH PALB2;IDENTIFICATION IN A BRCA COMPLEX WITH BRCA1 AND PALB2;CHARACTERIZATION OF VARIANT OVARIAN CANCER 1411-THR
48.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-395 AND SER-398;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
49.

"The UBXN1 protein associates with autoubiquitinated forms of the BRCA1 tumor suppressor and inhibits its enzymatic function."
Wu-Baer F. , Ludwig T. , Baer R.
Mol. Cell. Biol.30:2787-2798(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH BARD1 AND UBXN1;UBIQUITINATION;MUTAGENESIS OF ILE-26
50.

"The CHK2-BRCA1 tumour suppressor pathway ensures chromosomal stability in human somatic cells."
Stolz A. , Ertych N. , Kienitz A. , Vogel C. , Schneider V. , Fritz B. , Jacob R. , Dittmar G. , Weichert W. , Petersen I. , Bastians H.
Nat. Cell Biol.12:492-499(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CHROMOSOMAL STABILITY;PHOSPHORYLATION AT SER-988 BY CHEK2
51.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114; SER-423; SER-694; SER-1328; SER-1336 AND SER-1342;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
52.

"Protein phosphatase 5 is necessary for ATR-mediated DNA repair."
Kang Y. , Cheong H.M. , Lee J.H. , Song P.I. , Lee K.H. , Kim S.Y. , Jun J.Y. , You H.J.
Biochem. Biophys. Res. Commun.404:476-481(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-1524;SUBCELLULAR LOCATION
53.

"KIAA0101 interacts with BRCA1 and regulates centrosome number."
Kais Z. , Barsky S.H. , Mathsyaraja H. , Zha A. , Ransburgh D.J. , He G. , Pilarski R.T. , Shapiro C.L. , Huang K. , Parvin J.D.
Mol. Cancer Res.9:1091-1099(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KIAA0101
54.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-114; SER-1218; SER-1336 AND SER-1342;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
55.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
56.

"Structure of a BRCA1-BARD1 heterodimeric RING-RING complex."
Brzovic P.S. , Rajagopal P. , Hoyt D.W. , King M.C. , Klevit R.E.
Nat. Struct. Biol.8:833-837(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-110 IN COMPLEX WITH ZINC IONS AND BARD1;SUBUNIT
57.

"Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1."
Williams R.S. , Green R. , Glover J.N.
Nat. Struct. Biol.8:838-842(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1646-1859;PARTIAL PROTEIN SEQUENCE;IDENTIFICATION BY MASS SPECTROMETRY
58.

"Structural consequences of a cancer-causing BRCA1-BRCT missense mutation."
Williams R.S. , Glover J.N.
J. Biol. Chem.278:2630-2635(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 1646-1859 OF VARIANT BC ARG-1775;CHARACTERIZATION OF VARIANT BC ARG-1775;CIRCULAR DICHROISM
59.

"Solution structure, backbone dynamics, and association behavior of the C-terminal BRCT domain from the breast cancer-associated protein BRCA1."
Gaiser O.J. , Ball L.J. , Schmieder P. , Leitner D. , Strauss H. , Wahl M. , Kuhne R. , Oschkinat H. , Heinemann U.
Biochemistry43:15983-15995(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1755-1863
60.

"Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer."
Clapperton J.A. , Manke I.A. , Lowery D.M. , Ho T. , Haire L.F. , Yaffe M.B. , Smerdon S.J.
Nat. Struct. Mol. Biol.11:512-518(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 1649-1859 IN COMPLEX WITH WITH PHOSPHORYLATED BRIP1 PEPTIDE;MUTAGENESIS OF SER-1655; LYS-1702 AND GLY-1738;CHARACTERIZATION OF VARIANT OVARIAN CANCER ARG-1749;CHARACTERIZATION OF VARIANT BC ARG-1775;SUBCELLULAR LOCATION;INTERACTION WITH PHOSPHORYLATED BRIP1
61.

"Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex."
Varma A.K. , Brown R.S. , Birrane G. , Ladias J.A.
Biochemistry44:10941-10946(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 1646-1859 IN COMPLEX WITH PHOSPHORYLATED RBBP8 PEPTIDE;SUBUNIT
62.

"Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1."
Shen Y. , Tong L.
Biochemistry47:5767-5773(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.21 ANGSTROMS) OF 1646-1859 IN COMPLEX WITH PHOSPHORYLATED ACACA PEPTIDE;SUBUNIT
63.

"Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach."
Tischkowitz M. , Hamel N. , Carvalho M.A. , Birrane G. , Soni A. , van Beers E.H. , Joosse S.A. , Wong N. , Novak D. , Quenneville L.A. , Grist S.A. , Nederlof P.M. , Goldgar D.E. , Tavtigian S.V. , Monteiro A.N. , Ladias J.A. , Foulkes W.D.
Eur. J. Hum. Genet.16:820-832(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.6 ANGSTROMS) OF 1649-1859 OF VARIANT BC LYS-1775;VARIANT BC LYS-1775;CHARACTERIZATION OF VARIANT BC LYS-1775
64.

"Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1."
Campbell S.J. , Edwards R.A. , Glover J.N.
Structure18:167-176(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1646-1859 IN COMPLEX WITH PHOSPHORYLATED PEPTIDES;DOMAIN
65.

"Mutations and polymorphisms in the familial early-onset breast cancer (BRCA1) gene."
Couch F.J. , Weber B.L.
Hum. Mutat.8:8-18(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON VARIANTS
66.

"BRCA1 mutations in primary breast and ovarian carcinomas."
Futreal P.A. , Liu Q. , Shattuck-Eidens D. , Cochran C. , Harshman K. , Tavtigian S. , Bennett L.M. , Haugen-Strano A. , Swensen J. , Miki Y. , Eddington K. , McClure M. , Frye C. , Weaver-Felhaus J. , Ding W. , Gholami Z. , Soederkvist P. , Terry L. , more...
Science266:120-122(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC ARG-1775;VARIANTS LEU-1637 AND GLU-1708
67.

"Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer."
Castilla L.H. , Couch F.J. , Erdos M.R. , Hoskins K.F. , Calzone K. , Garber J.E. , Boyd J. , Lubin M.B. , Deshano M.L. , Brody L.C. , Collins F.S. , Weber B.L.
Nat. Genet.8:387-391(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC GLY-64;VARIANTS ALA-772; ASN-1040 AND GLY-1443
68.

"Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families."
Friedman L.S. , Ostermeyer E.A. , Szabo C.I. , Dowd P. , Lynch E.D. , Rowell S.E. , King M.-C.
Nat. Genet.8:399-404(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC GLY-61;VARIANTS ARG-356; GLY-1038; ASN-1040; ARG-1183 AND GLY-1613
69.

"A high incidence of BRCA1 mutations in 20 breast-ovarian cancer families."
Serova O. , Montagna M. , Torchard D. , Narod S.A. , Tonin P. , Sylla B. , Lynch H.T. , Feunteun J. , Lenoir G.M.
Am. J. Hum. Genet.58:42-51(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC GLY-61
70.

"BRCA1 R841W: a strong candidate for a common mutation with moderate phenotype."
Barker D.F. , Almeida E.F.A. , Casey G. , Fain P.R. , Liao S.-Y. , Masunaka I. , Noble B. , Kurosaki T. , Anton-Culver H.
Genet. Epidemiol.13:595-604(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BROVCA1 TRP-841
71.

"Comparison of BRCA1 polymorphisms, rare sequence variants and/or missense mutations in unaffected and breast/ovarian cancer populations."
Durocher F. , Shattuck-Eidens D. , McClure M. , Labrie F. , Skolnick M.H. , Goldgar D.E. , Simard J.
Hum. Mol. Genet.5:835-842(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC AND BROVCA1
72.

"Mutations in the BRCA1 gene in Japanese breast cancer patients."
Katagiri T. , Emi M. , Ito I. , Kobayashi K. , Yoshimoto M. , Iwase T. , Kasumi F. , Miki Y. , Skolnick M.H. , Nakamura Y.
Hum. Mutat.7:334-339(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC MET-271 AND SER-1150
73.

"A high proportion of mutations in the BRCA1 gene in German breast/ovarian cancer families with clustering of mutations in the 3' third of the gene."
Dong J. , Chang-Claude J. , Wu Y. , Schumacher V. , Debatin I. , Tonin P. , Royer-Pokora B.
Hum. Genet.103:154-161(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC GLY-61;VARIANTS ARG-239; TRP-841 AND ILE-1512
74.

"Constant denaturant gel electrophoresis (CDGE) in BRCA1 mutation screening."
Andersen T.I. , Eiken H.G. , Couch F. , Kaada G. , Skrede M. , Johnsen H. , Aloysius T.A. , Tveit K.M. , Tranebjaerg L. , Doerum A. , Moeller P. , Weber B.L. , Boerresen-Dale A.-L.
Hum. Mutat.11:166-174(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC GLY-64;VARIANTS ALA-772; GLU-820; ASN-1040; GLY-1443; ILE-1512; LEU-1637 AND ILE-1652
75.

"High proportion of missense mutations of the BRCA1 and BRCA2 genes in Japanese breast cancer families."
Katagiri T. , Kasumi F. , Yoshimoto M. , Nomizu T. , Asaishi K. , Abe R. , Tsuchiya A. , Sugano M. , Takai S. , Yoneda M. , Fukutomi T. , Nanba K. , Makita M. , Okazaki H. , Hirata K. , Okazaki M. , Furutsuma Y. , Morishita Y. , more...
J. Hum. Genet.43:42-48(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC SER-22; LEU-461; ASP-465; VAL-552; SER-892; ASP-960; ILE-1025 AND ALA-1047
76.

"The contribution of germline BRCA1 and BRCA2 mutations to familial ovarian cancer: no evidence for other ovarian cancer-susceptibility genes."
Gayther S.A. , Russell P. , Harrington P. , Antoniou A.C. , Easton D.F. , Ponder B.A.J.
Am. J. Hum. Genet.65:1021-1029(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OVARIAN CANCER ARG-1749
77.

"Molecular characterization of germline mutations in the BRCA1 and BRCA2 genes from breast cancer families in Taiwan."
Li S.S.-L. , Tseng H.-M. , Yang T.-P. , Liu C.-H. , Teng S.-J. , Huang H.-W. , Chen L.-M. , Kao H.-W. , Chen J.H. , Tseng J.-N. , Chen A. , Hou M.-F. , Huang T.-J. , Chang H.-T. , Mok K.-T. , Tsai J.-H.
Hum. Genet.104:201-204(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC SER-346;VARIANTS LEU-871; GLY-1038; ARG-1183 AND GLY-1613
78.

"Germline BRCA1 alterations in a population-based series of ovarian cancer cases."
Janezic S.A. , Ziogas A. , Krumroy L.M. , Krasner M. , Plummer S.J. , Cohen P. , Gildea M. , Barker D. , Haile R. , Casey G. , Anton-Culver H.
Hum. Mol. Genet.8:889-897(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OVARIAN CANCER;VARIANTS
79.

"Characterization of common BRCA1 and BRCA2 variants."
Deffenbaugh A.M. , Frank T.S. , Hoffman M. , Cannon-Albright L. , Neuhausen S.L.
Genet. Test.6:119-121(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLY-1347; ILE-1512 AND ILE-1652
80.

"BRCA1 and BRCA2 sequence variants in Chinese breast cancer families."
Zhi X. , Szabo C. , Chopin S. , Suter N. , Wang Q.-S. , Ostrander E.A. , Sinilnikova O.M. , Lenoir G.M. , Goldgar D. , Shi Y.-R.
Hum. Mutat.20:474-474(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-656; LEU-871 AND GLY-1613
81.

"BRCA1 and BRCA2 mutation analysis of early-onset and familial breast cancer cases in Mexico."
Ruiz-Flores P. , Sinilnikova O.M. , Badzioch M. , Calderon-Garciduenas A.L. , Chopin S. , Fabrice O. , Gonzalez-Guerrero J.F. , Szabo C. , Lenoir G. , Goldgar D.E. , Barrera-Saldana H.A.
Hum. Mutat.20:474-475(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BC TYR-749
82.

"Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and/or ovarian cancer families in Southern Germany."
Meyer P. , Voigtlaender T. , Bartram C.R. , Klaes R.
Hum. Mutat.22:259-259(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC GLY-61; LYS-71; GLN-866; TYR-888; ILE-1139; GLY-1210 AND PRO-1297;VARIANTS BROVCA1 TYR-835 AND PRO-1786
83.

"BRCA1 and BRCA2 germline mutation spectrum and frequencies in Belgian breast/ovarian cancer families."
Claes K. , Poppe B. , Coene I. , De Paepe A. , Messiaen L.
Br. J. Cancer90:1244-1251(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASN-693; ASN-1040; ALA-1060 AND MET-1665
84.

"One in 10 ovarian cancer patients carry germ line BRCA1 or BRCA2 mutations: results of a prospective study in Southern Sweden."
Malander S. , Ridderheim M. , Masbaeck A. , Loman N. , Kristoffersson U. , Olsson H. , Nilbert M. , Borg A.
Eur. J. Cancer40:422-428(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OVARIAN CANCER GLY-61; THR-1411; ARG-1697 AND TRP-1699
85.

"Novel germline mutations in the BRCA1 and BRCA2 genes in Indian breast and breast-ovarian cancer families."
Valarmathi M.T. , Sawhney M. , Deo S.S.V. , Shukla N.K. , Das S.N.
Hum. Mutat.23:205-205(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BC/BROVCA1 LYS-10; LYS-23; ILE-1187; HIS-1200 AND TYR-1217;VARIANTS BC ILE-1204 AND ASN-1207;VARIANTS BROVCA1 LEU-1226 AND GLY-1243;VARIANT ARG-1183
86.

"BRCA1 and BRCA2 germline mutations in Korean patients with sporadic breast cancer."
Seo J.H. , Cho D.-Y. , Ahn S.-H. , Yoon K.-S. , Kang C.-S. , Cho H.M. , Lee H.S. , Choe J.J. , Choi C.W. , Kim B.S. , Shin S.W. , Kim Y.H. , Kim J.S. , Son G.-S. , Lee J.-B. , Koo B.H.
Hum. Mutat.24:350-350(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-856; LEU-871; GLY-1038; ARG-1183; THR-1628; GLN-1690 AND GLY-1713
87.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] PHE-30; PHE-758 AND CYS-778
88.

"A systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genes."
Easton D.F. , Deffenbaugh A.M. , Pruss D. , Frye C. , Wenstrup R.J. , Allen-Brady K. , Tavtigian S.V. , Monteiro A.N.A. , Iversen E.S. , Couch F.J. , Goldgar D.E.
Am. J. Hum. Genet.81:873-883(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-18; MET-1495; GLY-1623; ILE-1685; ALA-1685; ARG-1689; TRP-1699; GLU-1706; GLU-1708; ARG-1715; ARG-1738; PRO-1764; SER-1766 AND VAL-1788
89.

"Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: implications for prediction of pathogenicity."
Walker L.C. , Whiley P.J. , Couch F.J. , Farrugia D.J. , Healey S. , Eccles D.M. , Lin F. , Butler S.A. , Goff S.A. , Thompson B.A. , Lakhani S.R. , Da Silva L.M. , Tavtigian S.V. , Goldgar D.E. , Brown M.A. , Spurdle A.B.
Hum. Mutat.31:E1484-E1505(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS GLY-1623 AND ILE-1685
90.

"A high-throughput functional complementation assay for classification of BRCA1 missense variants."
Bouwman P. , van der Gulden H. , van der Heijden I. , Drost R. , Klijn C.N. , Prasetyanti P. , Pieterse M. , Wientjens E. , Seibler J. , Hogervorst F.B. , Jonkers J.
Cancer Discov.3:1142-1155(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS BC PHE-4; THR-18; GLN-45; GLY-61; GLY-64; TYR-67; LYS-132; HIS-142; PHE-147; PRO-165; TRP-170; TYR-186; ILE-191; MET-231; VAL-245; VAL-246; LEU-271; PHE-668; ASN-695; LEU-798; TYR-810; LYS-826; GLN-841; HIS-856; ASN-1101; ASN-1140; GLY-1140; LYS-1214; LYS-1236; SER-1267; VAL-1282; SER-1297 DEL; ARG-1301; LYS-1346; ILE-1378; VAL-1400; PRO-1407; THR-1411; GLY-1443; GLY-1448; CYS-1486; MET-1534; PRO-1589; THR-1628; PRO-1651; PHE-1651; PHE-1655; ARG-1686; GLN-1686; VAL-1688 DEL; ILE-1691; TRP-1699; GLN-1699; GLU-1706; ALA-1706; GLU-1708; CYS-1718; ALA-1720; LYS-1735; ALA-1736; GLY-1739; VAL-1739; GLN-1746; THR-1753; PRO-1764; SER-1767; VAL-1770; CYS-1782; THR-1789; ASP-1794; ASP-1804; ARG-1812; ARG-1837 AND LEU-1862;VARIANTS CYS-105; CYS-866; ALA-1060; LYS-1250 AND ILE-1652

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