Gene name:
BTK (AGMX1;ATK;BPK) ;
Protein name:
Tyrosine-protein kinase BTK ;
Alternative:
B-cell progenitor kinase (BPK) ;Agammaglobulinaemia tyrosine kinase (ATK) ;Bruton tyrosine kinase ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds GTF2I through the PH domain. Interacts with SH3BP5 via the SH3 domain. Interacts with IBTK via its PH domain. Interacts with ARID3A, CAV1, FASLG, PIN1, TLR8 and TLR9.
Function:
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker protein BLNK. BTK acts as a platform to bring together a diverse array of signaling proteins and is implicated in cytokine receptor signaling pathways. Plays an important role in the function of immune cells of innate as well as adaptive immunity, as a component of the Toll-like receptors (TLR) pathway. The TLR pathway acts as a primary surveillance system for the detection of pathogens and are crucial to the activation of host defense. Especially, is a critical molecule in regulating TLR9 activation in splenic B-cells. Within the TLR pathway, induces tyrosine phosphorylation of TIRAP which leads to TIRAP degradation. BTK plays also a critical role in transcription regulation. Induces the activity of NF-kappa-B, which is involved in regulating the expression of hundreds of genes. BTK is involved on the signaling pathway linking TLR8 and TLR9 to NF-kappa-B. Transiently phosphorylates transcription factor GTF2I on tyrosine residues in response to BCR. GTF2I then translocates to the nucleus to bind regulatory enhancer elements to modulate gene expression. ARID3A and NFAT are other transcriptional target of BTK. BTK is required for the formation of functional ARID3A DNA-binding complexes. There is however no evidence that BTK itself binds directly to DNA. BTK has a dual role in the regulation of apoptosis.
Subcellular Location:
Cytoplasm
Cell membrane
Peripheral membrane protein
Nucleus
In steady state, BTK is predominantly cytosolic. Following B-cell receptor (BCR) engagement by antigen, translocates to the plasma membrane through its PH domain. Plasma membrane localization is a critical step in the activation of BTK. A fraction of BTK also shuttles between the nucleus and the cytoplasm, and nuclear export is mediated by the nuclear export receptor CRM1.
Protein Attributes:
50:
MAAVILESIF | LKRSQQKKKT | SPLNFKKRLF | LLTVHKLSYY | EYDFERGRRG |
100:
SKKGSIDVEK | ITCVETVVPE | KNPPPERQIP | RRGEESSEME | QISIIERFPY |
150:
PFQVVYDEGP | LYVFSPTEEL | RKRWIHQLKN | VIRYNSDLVQ | KYHPCFWIDG |
200:
QYLCCSQTAK | NAMGCQILEN | RNGSLKPGSS | HRKTKKPLPP | TPEEDQILKK |
250:
PLPPEPAAAP | VSTSELKKVV | ALYDYMPMNA | NDLQLRKGDE | YFILEESNLP |
300:
WWRARDKNGQ | EGYIPSNYVT | EAEDSIEMYE | WYSKHMTRSQ | AEQLLKQEGK |
350:
EGGFIVRDSS | KAGKYTVSVF | AKSTGDPQGV | IRHYVVCSTP | QSQYYLAEKH |
400:
LFSTIPELIN | YHQHNSAGLI | SRLKYPVSQQ | NKNAPSTAGL | GYGSWEIDPK |
450:
DLTFLKELGT | GQFGVVKYGK | WRGQYDVAIK | MIKEGSMSED | EFIEEAKVMM |
500:
NLSHEKLVQL | YGVCTKQRPI | FIITEYMANG | CLLNYLREMR | HRFQTQQLLE |
550:
MCKDVCEAME | YLESKQFLHR | DLAARNCLVN | DQGVVKVSDF | GLSRYVLDDE |
600:
YTSSVGSKFP | VRWSPPEVLM | YSKFSSKSDI | WAFGVLMWEI | YSLGKMPYER |
650:
FTNSETAEHI | AQGLRLYRPH | LASEKVYTIM | YSCWHEKADE | RPTFKILLSN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Chicken
ELISA Kit for Human Tyrosine-protein kinase BTK
ELISA Kit for Human Tyrosine-protein kinase BTK
ELISA Kit for Human Tyrosine-protein kinase BTK
CLIA Kit for Human Tyrosine-protein kinase BTK
CLIA Kit for Human Tyrosine-protein kinase BTK
CLIA Kit for Human Tyrosine-protein kinase BTK
Polyclonal Antibody for Human Tyrosine-protein kinase BTK
Polyclonal Antibody for Human Tyrosine-protein kinase BTK
Polyclonal Antibody for Human Tyrosine-protein kinase BTK
Monoclonal Antibody for Human Tyrosine-protein kinase BTK
Monoclonal Antibody for Human Tyrosine-protein kinase BTK
Monoclonal Antibody for Human Tyrosine-protein kinase BTK
Protein for Human Tyrosine-protein kinase BTK
Protein for Human Tyrosine-protein kinase BTK
Protein for Human Tyrosine-protein kinase BTK
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases."
Vetrie D.
,
Vorechovsky I.
,
Sideras P.
,
Holland J.
,
Davies A.
,
Flinter F.
,
Hammarstroem L.
,
Kinnon C.
,
Levinsky R.J.
,
Bobrow M.
,
Smith C.I.E.
,
Bentley D.R.
Nature361:226-233(1993)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM BTK-A)
2.
Vetrie D.
,
Vorechovsky I.
,
Sideras P.
,
Holland J.
,
Davies A.
,
Flinter F.
,
Hammarstroem L.
,
Kinnon C.
,
Levinsky R.J.
,
Bobrow M.
,
Smith C.I.E.
,
Bentley D.R.
Nature364:362-362(1993)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue :
Blood .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS XLA SER-334; ARG-506; GLN-520; TRP-562 AND LYS-630
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BTK-A)
tissue :
Umbilical cord blood .
8.
"The DNA sequence of the human X chromosome."
Ross M.T.
,
Grafham D.V.
,
Coffey A.J.
,
Scherer S.
,
McLay K.
,
Muzny D.
,
Platzer M.
,
Howell G.R.
,
Burrows C.
,
Bird C.P.
,
Frankish A.
,
Lovell F.L.
,
Howe K.L.
,
Ashurst J.L.
,
Fulton R.S.
,
Sudbrak R.
,
Wen G.
,
Jones M.C.
,
Hurles M.E.
,
Andrews T.D.
,
Scott C.E.
,
Searle S.
,
Ramser J.
,
Whittaker A.
,
Deadman R.
,
Carter N.P.
,
Hunt S.E.
,
Chen R.
,
Cree A.
,
Gunaratne P.
,
Havlak P.
,
Hodgson A.
,
Metzker M.L.
,
Richards S.
,
Scott G.
,
Steffen D.
,
Sodergren E.
,
Wheeler D.A.
,
Worley K.C.
,
Ainscough R.
,
Ambrose K.D.
,
Ansari-Lari M.A.
,
Aradhya S.
,
Ashwell R.I.
,
Babbage A.K.
,
Bagguley C.L.
,
Ballabio A.
,
Banerjee R.
,
Barker G.E.
,
Barlow K.F.
,
Barrett I.P.
,
Bates K.N.
,
Beare D.M.
,
Beasley H.
,
Beasley O.
,
Beck A.
,
Bethel G.
,
Blechschmidt K.
,
Brady N.
,
Bray-Allen S.
,
Bridgeman A.M.
,
Brown A.J.
,
Brown M.J.
,
Bonnin D.
,
Bruford E.A.
,
Buhay C.
,
Burch P.
,
Burford D.
,
Burgess J.
,
Burrill W.
,
Burton J.
,
Bye J.M.
,
Carder C.
,
Carrel L.
,
Chako J.
,
Chapman J.C.
,
Chavez D.
,
Chen E.
,
Chen G.
,
Chen Y.
,
Chen Z.
,
Chinault C.
,
Ciccodicola A.
,
Clark S.Y.
,
Clarke G.
,
Clee C.M.
,
Clegg S.
,
Clerc-Blankenburg K.
,
Clifford K.
,
Cobley V.
,
Cole C.G.
,
Conquer J.S.
,
Corby N.
,
Connor R.E.
,
David R.
,
Davies J.
,
Davis C.
,
Davis J.
,
Delgado O.
,
Deshazo D.
,
Dhami P.
,
Ding Y.
,
Dinh H.
,
Dodsworth S.
,
Draper H.
,
Dugan-Rocha S.
,
Dunham A.
,
Dunn M.
,
Durbin K.J.
,
Dutta I.
,
Eades T.
,
Ellwood M.
,
Emery-Cohen A.
,
Errington H.
,
Evans K.L.
,
Faulkner L.
,
Francis F.
,
Frankland J.
,
Fraser A.E.
,
Galgoczy P.
,
Gilbert J.
,
Gill R.
,
Gloeckner G.
,
Gregory S.G.
,
Gribble S.
,
Griffiths C.
,
Grocock R.
,
Gu Y.
,
Gwilliam R.
,
Hamilton C.
,
Hart E.A.
,
Hawes A.
,
Heath P.D.
,
Heitmann K.
,
Hennig S.
,
Hernandez J.
,
Hinzmann B.
,
Ho S.
,
Hoffs M.
,
Howden P.J.
,
Huckle E.J.
,
Hume J.
,
Hunt P.J.
,
Hunt A.R.
,
Isherwood J.
,
Jacob L.
,
Johnson D.
,
Jones S.
,
de Jong P.J.
,
Joseph S.S.
,
Keenan S.
,
Kelly S.
,
Kershaw J.K.
,
Khan Z.
,
Kioschis P.
,
Klages S.
,
Knights A.J.
,
Kosiura A.
,
Kovar-Smith C.
,
Laird G.K.
,
Langford C.
,
Lawlor S.
,
Leversha M.
,
Lewis L.
,
Liu W.
,
Lloyd C.
,
Lloyd D.M.
,
Loulseged H.
,
Loveland J.E.
,
Lovell J.D.
,
Lozado R.
,
Lu J.
,
Lyne R.
,
Ma J.
,
Maheshwari M.
,
Matthews L.H.
,
McDowall J.
,
McLaren S.
,
McMurray A.
,
Meidl P.
,
Meitinger T.
,
Milne S.
,
Miner G.
,
Mistry S.L.
,
Morgan M.
,
Morris S.
,
Mueller I.
,
Mullikin J.C.
,
Nguyen N.
,
Nordsiek G.
,
Nyakatura G.
,
O'dell C.N.
,
Okwuonu G.
,
Palmer S.
,
Pandian R.
,
Parker D.
,
Parrish J.
,
Pasternak S.
,
Patel D.
,
Pearce A.V.
,
Pearson D.M.
,
Pelan S.E.
,
Perez L.
,
Porter K.M.
,
Ramsey Y.
,
Reichwald K.
,
Rhodes S.
,
Ridler K.A.
,
Schlessinger D.
,
Schueler M.G.
,
Sehra H.K.
,
Shaw-Smith C.
,
Shen H.
,
Sheridan E.M.
,
Shownkeen R.
,
Skuce C.D.
,
Smith M.L.
,
Sotheran E.C.
,
Steingruber H.E.
,
Steward C.A.
,
Storey R.
,
Swann R.M.
,
Swarbreck D.
,
Tabor P.E.
,
Taudien S.
,
Taylor T.
,
Teague B.
,
Thomas K.
,
Thorpe A.
,
Timms K.
,
Tracey A.
,
Trevanion S.
,
Tromans A.C.
,
d'Urso M.
,
Verduzco D.
,
Villasana D.
,
Waldron L.
,
Wall M.
,
Wang Q.
,
Warren J.
,
Warry G.L.
,
Wei X.
,
West A.
,
Whitehead S.L.
,
Whiteley M.N.
,
Wilkinson J.E.
,
Willey D.L.
,
Williams G.
,
Williams L.
,
Williamson A.
,
Williamson H.
,
Wilming L.
,
Woodmansey R.L.
,
Wray P.W.
,
Yen J.
,
Zhang J.
,
Zhou J.
,
Zoghbi H.
,
Zorilla S.
,
Buck D.
,
Reinhardt R.
,
Poustka A.
,
Rosenthal A.
,
Lehrach H.
,
Meindl A.
,
Minx P.J.
,
Hillier L.W.
,
Willard H.F.
,
Wilson R.K.
,
Waterston R.H.
,
Rice C.M.
,
Vaudin M.
,
Coulson A.
,
Nelson D.L.
,
Weinstock G.
,
Sulston J.E.
,
Durbin R.M.
,
Hubbard T.
,
Gibbs R.A.
,
Beck S.
,
Rogers J.
,
Bentley D.R.
more...
Nature434:325-337(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM BTK-A)
10.
"Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia."
Tsukada S.
,
Saffran D.C.
,
Rawlings D.J.
,
Parolini O.
,
Allen R.C.
,
Klisak I.
,
Sparkes R.S.
,
Kubagawa H.
,
Mohandas T.
,
Quan S.
,
Belmont J.W.
,
Cooper M.D.
,
Conley M.E.
,
Witte O.N.
Cell72:279-290(1993)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE OF 1-442
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-12 AND 323-332;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Platelet .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 219-235;PHOSPHORYLATION AT TYR-223
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN XLA-IGHD
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DOMAIN PH
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-223 AND TYR-551;MUTAGENESIS OF TYR-223;ENZYME REGULATION
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF GTF2I;PHOSPHORYLATION AT TYR-223 AND TYR-551;MUTAGENESIS OF GLU-41; PRO-189; TYR-223; TRP-251; ARG-307 AND TYR-551
17.
"Identification and characterization of a novel SH3-domain binding protein, Sab, which preferentially associates with Bruton's tyrosine kinase (Btk)."
Matsushita M.
,
Yamadori T.
,
Kato S.
,
Takemoto Y.
,
Inazawa J.
,
Baba Y.
,
Hashimoto S.
,
Sekine S.
,
Arai S.
,
Kunikata T.
,
Kurimoto M.
,
Kishimoto T.
,
Tsukada S.
Biochem. Biophys. Res. Commun.245:337-343(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF 251-TRP-TRP-252;INTERACTION WITH SH3BP5
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DOMAIN PH;SUBCELLULAR LOCATION
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SH3BP5;ENZYME REGULATION
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
22.
"PKCbeta modulates antigen receptor signaling via regulation of Btk membrane localization."
Kang S.W.
,
Wahl M.I.
,
Chu J.
,
Kitaura J.
,
Kawakami Y.
,
Kato R.M.
,
Tabuchi R.
,
Tarakhovsky A.
,
Kawakami T.
,
Turck C.W.
,
Witte O.N.
,
Rawlings D.J.
EMBO J.20:5692-5702(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-180;ENZYME REGULATION
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF PLCG2
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH IBTK;ENZYME REGULATION
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DOMAIN;INTERACTION WITH CAV1;SUBCELLULAR LOCATION;ENZYME REGULATION
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-617 AND SER-623;MUTAGENESIS OF TYR-617
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PIN1;PHOSPHORYLATION AT SER-21 AND SER-115;ENZYME REGULATION
28.
"Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production."
Horwood N.J.
,
Page T.H.
,
McDaid J.P.
,
Palmer C.D.
,
Campbell J.
,
Mahon T.
,
Brennan F.M.
,
Webster D.
,
Foxwell B.M.
J. Immunol.176:3635-3641(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN THE TLR PATHWAY
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GTF2I AND ARID3A;FUNCTION
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PHOSPHORYLATION OF TIRAP;ENZYME REGULATION
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH TLR8 AND TLR9;ENZYME REGULATION;PHOSPHORYLATION AT TYR-223
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FASLG
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION IN REGULATION OF APOPTOSIS
34.
"Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain."
Mohamed A.J.
,
Yu L.
,
Backesjo C.M.
,
Vargas L.
,
Faryal R.
,
Aints A.
,
Christensson B.
,
Berglof A.
,
Vihinen M.
,
Nore B.F.
,
Smith C.I.
Immunol. Rev.228:58-73(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON FUNCTION;REVIEW ON ENZYME REGULATION
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55; THR-191; TYR-361 AND SER-659;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
36.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
37.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE PROMOTER USAGE (ISOFORM BTK-C)
38.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 2-170 IN COMPLEX WITH ZINC
39.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 212-275
40.
"Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate."
Baraldi E.
,
Carugo K.D.
,
Hyvoenen M.
,
Surdo P.L.
,
Riley A.M.
,
Potter B.V.L.
,
O'Brien R.
,
Ladbury J.E.
,
Saraste M.
Structure7:449-460(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-170 IN COMPLEX WITH INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE AND ZINC;DOMAIN PH
41.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 216-273
42.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 397-659
43.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 270-386
44.
"A novel, specific Btk inhibitor antagonizes BCR and Fc[gamma]R signaling and suppresses inflammatory arthritis."
Di Paolo J.A.
,
Huang T.
,
Balazs M.
,
Barbosa J.
,
Barck K.H.
,
Carano R.A.D.
,
Darrow J.
,
Davies D.R.
,
DeForge L.E.
,
Dennis G. Jr.
,
Diehl L.
,
Ferrando R.
Submitted (2010-08) to the PDB data bank
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 393-656 IN COMPLEX WITH INHIBITOR
45.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.58 ANGSTROMS) OF 2-170 IN COMPLEX WITH INHIBITOR AND ZINC
46.
"Structures of human Bruton's tyrosine kinase in active and inactive conformations suggest a mechanism of activation for TEC family kinases."
Marcotte D.J.
,
Liu Y.T.
,
Arduini R.M.
,
Hession C.A.
,
Miatkowski K.
,
Wildes C.P.
,
Cullen P.F.
,
Hong V.
,
Hopkins B.T.
,
Mertsching E.
,
Jenkins T.J.
,
Romanowski M.J.
,
Baker D.P.
,
Silvian L.F.
Protein Sci.19:429-439(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 382-659 IN COMPLEX WITH INHIBITOR DASATINIB
47.
"A novel, specific BTK inhibitor antagonizes BCR and FcgR signaling and suppresses inflammatory arthritis."
Di Paolo J.
,
Huang T.
,
Balazs M.
,
Barbosa J.
,
Barck K.H.
,
Bravo B.
,
Carano R.A.D.
,
Darrow J.
,
Davies D.R.
,
DeForge L.E.
,
Diehl L.
,
Ferrando R.
,
Gallion S.L.
,
Gianetti A.M.
,
Gribling P.
,
Hurez V.
,
Hymowitz S.G.
,
Jones R.
,
Kropf J.E.
,
Lee W.P.
,
Maciejewski P.M.
,
Mitchell S.A.
,
Rong H.
,
Staker B.L.
,
Whitney J.A.
,
Yeh S.
,
Young W.
,
Yu C.
,
Zhang J.
,
Reif K.
,
Currie K.S.
more...
Submitted (2010-09) to the PDB data bank
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 393-659
48.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 387-659 IN COMPLEX WITH INHIBITOR
49.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON VARIANTS XLA
50.
"BTKbase, mutation database for X-linked agammaglobulinemia (XLA)."
Vihinen M.
,
Belohradsky B.H.
,
Haire R.N.
,
Holinski-Feder E.
,
Kwan S.-P.
,
Lappalainen I.
,
Lehvaeslaiho H.
,
Lester T.
,
Meindl A.
,
Ochs H.D.
,
Ollila J.
,
Vorechovsky I.
,
Weiss M.
,
Smith C.I.E.
Nucleic Acids Res.25:166-171(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON VARIANTS XLA
51.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA TRP-288; GLY-307; ASP-607 AND SER-VAL-PHE-SER-SER-THR-ARG-103 INS
52.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA HIS-28 AND TRP-288
53.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA ASP-113; CYS-361; GLN-520; PRO-542; TRP-562; LYS-630 AND PRO-652
54.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA HIS-28; PRO-33; PRO-408; GLY-589; ASP-613 AND 260-GLN--GLU-280 DEL
55.
"Structural basis for chromosome X-linked agammaglobulinemia: a tyrosine kinase disease."
Vihinen M.
,
Vetrie D.
,
Maniar H.S.
,
Ochs H.D.
,
Zhu Q.
,
Vorechovsky I.
,
Webster A.D.B.
,
Notarangelo L.D.
,
Nilsson L.
,
Sowadski J.M.
,
Smith C.I.E.
Proc. Natl. Acad. Sci. U.S.A.91:12803-12807(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA GLU-430; GLN-520; GLN-525; PRO-562; VAL-582; GLY-589; GLU-594 AND ASP-613
56.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT XLA PHE-64;CHARACTERIZATION OF OTHER XLA VARIANTS
57.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA SER-25; TRP-288; MET-370; VAL-509; PRO-525; LYS-526; TRP-562; VAL-582 AND ARG-594
58.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA LYS-567; LEU-587 AND HIS-641
59.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA PRO-33; GLY-302 DEL; GLN-520 AND CYS-641
60.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA ASN-429 AND ARG-477
61.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA GLU-302 AND ASP-476
62.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT XLA PHE-358
63.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT XLA PRO-295
64.
"Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan."
Hashimoto S.
,
Tsukada S.
,
Matsushita M.
,
Miyawaki T.
,
Niida Y.
,
Yachie A.
,
Kobayashi S.
,
Iwata T.
,
Hayakawa H.
,
Matsuoka H.
,
Tsuge I.
,
Yamadori T.
,
Kunikata T.
,
Arai S.
,
Yoshizaki K.
,
Taniguchi N.
,
Kishimoto T.
Blood88:561-573(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA ARG-12; PRO-28; GLU-302; TRP-502; HIS-521; TYR-633 AND SER-644
65.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA TRP-288; LYS-544 AND PRO-592
66.
"Missense mutations affecting a conserved cysteine pair in the TH domain of Btk."
Vihinen M.
,
Nore B.
,
Mattsson P.T.
,
Backesj C.-M.
,
Nars M.
,
Koutaniemi S.
,
Watanabe C.
,
Lester T.
,
Jones A.M.
,
Ochs H.D.
,
Smith C.I.E.
FEBS Lett.413:205-210(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA SER-154 AND ARG-155
67.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA
68.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA GLN-288; THR-307; ARG-430; ASP-445; GLY-525; PHE-535; LEU-563 AND PRO-622
69.
"Mutation screening of the BTK gene in 56 families with X-linked agammaglobulinemia (XLA): 47 unique mutations without correlation to clinical course."
Holinski-Feder E.
,
Weiss M.
,
Brandau O.
,
Jedele K.B.
,
Nore B.
,
Baeckesjoe C.-M.
,
Vihinen M.
,
Hubbard S.R.
,
Belohradsky B.H.
,
Smith C.I.E.
,
Meindl A.
Pediatrics101:276-284(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA GLU-19; HIS-28; ASN-61; PRO-117; HIS-127; ARG-155; PRO-295; PHE-369; GLY-372; ARG-414; TYR-506; GLY-521; GLN-525; SER-559; TRP-562; GLU-594; THR-619; GLY-626 AND HIS-641
70.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA
71.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT XLA PRO-562
72.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS XLA SER-39; PRO-512; GLN-512; GLY-544; TYR-578 AND LYS-589
73.
"Patterns of somatic mutation in human cancer genomes."
Greenman C.
,
Stephens P.
,
Smith R.
,
Dalgliesh G.L.
,
Hunter C.
,
Bignell G.
,
Davies H.
,
Teague J.
,
Butler A.
,
Stevens C.
,
Edkins S.
,
O'Meara S.
,
Vastrik I.
,
Schmidt E.E.
,
Avis T.
,
Barthorpe S.
,
Bhamra G.
,
Buck G.
,
Choudhury B.
,
Clements J.
,
Cole J.
,
Dicks E.
,
Forbes S.
,
Gray K.
,
Halliday K.
,
Harrison R.
,
Hills K.
,
Hinton J.
,
Jenkinson A.
,
Jones D.
,
Menzies A.
,
Mironenko T.
,
Perry J.
,
Raine K.
,
Richardson D.
,
Shepherd R.
,
Small A.
,
Tofts C.
,
Varian J.
,
Webb T.
,
West S.
,
Widaa S.
,
Yates A.
,
Cahill D.P.
,
Louis D.N.
,
Goldstraw P.
,
Nicholson A.G.
,
Brasseur F.
,
Looijenga L.
,
Weber B.L.
,
Chiew Y.-E.
,
DeFazio A.
,
Greaves M.F.
,
Green A.R.
,
Campbell P.
,
Birney E.
,
Easton D.F.
,
Chenevix-Trench G.
,
Tan M.-H.
,
Khoo S.K.
,
Teh B.T.
,
Yuen S.T.
,
Leung S.Y.
,
Wooster R.
,
Futreal P.A.
,
Stratton M.R.
more...
Nature446:153-158(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS [LARGE SCALE ANALYSIS] LYS-82 AND LYS-190