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Index > Protein center > MTHFD1L(Gene name) > Human
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  • MTHFD1L (Gene name),
  • Monofunctional C1-tetrahydrofolate synthase, mitochondrial (Protein name ),  C1TM_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MTHFD1L(FTHFSDC1);
    Protein name:
    Monofunctional C1-tetrahydrofolate synthase, mitochondrial;
    Alternative:
    Formyltetrahydrofolate synthetase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2.
    Subcellular Location:
    Mitochondrion
    Protein Attributes:
    Sequence length:
    978
    Sequence:
    50:
    MGTRLPLVLR | QLRRPPQPPG | PPRRLRVPCR | ASSGGGGGGG | GGREGLLGQR | 
    100:
    RPQDGQARSS | CSPGGRTPAA | RDSIVREVIQ | NSKEVLSLLQ | EKNPAFKPVL | 
    150:
    AIIQAGDDNL | MQEINQNLAE | EAGLNITHIC | LPPDSSEAEI | IDEILKINED | 
    200:
    TRVHGLALQI | SENLFSNKVL | NALKPEKDVD | GVTDINLGKL | VRGDAHECFV | 
    250:
    SPVAKAVIEL | LEKSGVNLDG | KKILVVGAHG | SLEAALQCLF | QRKGSMTMSI | 
    300:
    QWKTRQLQSK | LHEADIVVLG | SPKPEEIPLT | WIQPGTTVLN | CSHDFLSGKV | 
    350:
    GCGSPRIHFG | GLIEEDDVIL | LAAALRIQNM | VSSGRRWLRE | QQHRRWRLHC | 
    400:
    LKLQPLSPVP | SDIEISRGQT | PKAVDVLAKE | IGLLADEIEI | YGKSKAKVRL | 
    450:
    SVLERLKDQA | DGKYVLVAGI | TPTPLGEGKS | TVTIGLVQAL | TAHLNVNSFA | 
    500:
    CLRQPSQGPT | FGVKGGAAGG | GYAQVIPMEE | FNLHLTGDIH | AITAANNLLA | 
    550:
    AAIDTRILHE | NTQTDKALYN | RLVPLVNGVR | EFSEIQLARL | KKLGINKTDP | 
    600:
    STLTEEEVSK | FARLDIDPST | ITWQRVLDTN | DRFLRKITIG | QGNTEKGHYR | 
    650:
    QAQFDIAVAS | EIMAVLALTD | SLADMKARLG | RMVVASDKSG | QPVTADDLGV | 
    700:
    TGALTVLMKD | AIKPNLMQTL | EGTPVFVHAG | PFANIAHGNS | SVLADKIALK | 
    750:
    LVGEEGFVVT | EAGFGADIGM | EKFFNIKCRA | SGLVPNVVVL | VATVRALKMH | 
    800:
    GGGPSVTAGV | PLKKEYTEEN | IQLVADGCCN | LQKQIQITQL | FGVPVVVALN | 
    850:
    VFKTDTRAEI | DLVCELAKRA | GAFDAVPCYH | WSVGGKGSVD | LARAVREAAS | 
    900:
    KRSRFQFLYD | VQVPIVDKIR | TIAQAVYGAK | DIELSPEAQA | KIDRYTQQGF | 
    950:
    GNLPICMAKT | HLSLSHQPDK | KGVPRDFILP | ISDVRASIGA | GFIYPLVGTM | 
    978:
    STMPGLPTRP | CFYDIDLDTE | TEQVKGLF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    MIM:
    KEGG:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Cat.:
    E13446b
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Cat.:
    E13446h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Cat.:
    E13446m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Cat.:
    U13446m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Cat.:
    U13446h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Cat.:
    U13446b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Cat.:
    P13446Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Polyclonal Antibody for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Monoclonal Antibody for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Monoclonal Antibody for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Monoclonal Antibody for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Protein for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Cat.:
    R13446h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial
    Protein for Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial

    R&D Technical Data
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     12% SDS-PAGE analysis

            12% SDS-PAGE analysis

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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Human mitochondrial C1-tetrahydrofolate synthase: gene structure, tissue distribution of the mRNA, and immunolocalization in Chinese hamster ovary calls."
      Prasannan P. , Pike S. , Peng K. , Shane B. , Appling D.R.
      J. Biol. Chem.278:43178-43187(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      "A novel mitochondrial C1-tetrahydrofolate synthetase is upregulated in human colon adenocarcinoma."
      Sugiura T. , Nagano Y. , Inoue T. , Hirotani K.
      Biochem. Biophys. Res. Commun.315:204-211(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
      tissue: Testis.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Enzymatic characterization of human mitochondrial C1-tetrahydrofolate synthase."
      Walkup A.S. , Appling D.R.
      Arch. Biochem. Biophys.442:196-205(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 32-66;FUNCTION;SUBUNIT;BIOPHYSICOCHEMICAL PROPERTIES
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 62-978 (ISOFORM 1)
      tissue: Uterus.
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 79-978 (ISOFORM 1)
      tissue: Cervix.
      tissue: Eye.
      tissue: Muscle.
    8. 8.
      Bienvenut W.V. , Matallanas D. , Cooper W.N. , Kolch W.
      Submitted (2007-07) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 522-530; 564-575 AND 926-935;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Mammary carcinoma.
    9. 9.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 591-978 (ISOFORM 1)
    10. 10.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-189;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] ARG-444
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