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Index > Protein center > C4BPA(Gene name) > Human
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  • C4BPA (Gene name),
  • C4b-binding protein alpha chain (Protein name ),  C4BPA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    C4BPA(C4BP);
    Protein name:
    C4b-binding protein alpha chain(C4bp);
    Alternative:
    Proline-rich protein(PRP);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Disulfide-linked complex of alpha and beta chains of 3 possible sorts: a 570 kDa complex of 7 alpha chains and 1 beta chain, a 530 kDa homoheptamer of alpha chains or a 500 kDa complex of 6 alpha chains and 1 beta chain. The central body of the alpha chain homopolymer supports tentacles, each with the binding site for C4b at the end.
    Function:
    Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    597
    Sequence:
    50:
    MHPPKTPSGA | LHRKRKMAAW | PFSRLWKVSD | PILFQMTLIA | ALLPAVLGNC | 
    100:
    GPPPTLSFAA | PMDITLTETR | FKTGTTLKYT | CLPGYVRSHS | TQTLTCNSDG | 
    150:
    EWVYNTFCIY | KRCRHPGELR | NGQVEIKTDL | SFGSQIEFSC | SEGFFLIGST | 
    200:
    TSRCEVQDRG | VGWSHPLPQC | EIVKCKPPPD | IRNGRHSGEE | NFYAYGFSVT | 
    250:
    YSCDPRFSLL | GHASISCTVE | NETIGVWRPS | PPTCEKITCR | KPDVSHGEMV | 
    300:
    SGFGPIYNYK | DTIVFKCQKG | FVLRGSSVIH | CDADSKWNPS | PPACEPNSCI | 
    350:
    NLPDIPHASW | ETYPRPTKED | VYVVGTVLRY | RCHPGYKPTT | DEPTTVICQK | 
    400:
    NLRWTPYQGC | EALCCPEPKL | NNGEITQHRK | SRPANHCVYF | YGDEISFSCH | 
    450:
    ETSRFSAICQ | GDGTWSPRTP | SCGDICNFPP | KIAHGHYKQS | SSYSFFKEEI | 
    500:
    IYECDKGYIL | VGQAKLSCSY | SHWSAPAPQC | KALCRKPELV | NGRLSVDKDQ | 
    550:
    YVEPENVTIQ | CDSGYGVVGP | QSITCSGNRT | WYPEVPKCEW | ETPEGCEQVL | 
    597:
    TGKRLMQCLP | NPEDVKMALE | VYKLSLEIEQ | LELQRDSARQ | STLDKEL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    KEGG:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human C4bp
    Cat.:
    E0761h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human C4bp
    Cat.:
    E0761r
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    Packing:
    96T
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    ELISA Kit for Human C4bp
    Cat.:
    E0761m
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    Packing:
    96T
    ELISA Kit for Human C4bp
    Cat.:
    E0761b
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    Packing:
    96T
    CLIA Kit for Human C4bp
    Cat.:
    U0761m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human C4bp
    Cat.:
    U0761h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human C4bp
    Cat.:
    U0761b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human C4bp
    Cat.:
    U0761r
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human C4bp
    Cat.:
    P0761Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human C4bp
    Cat.:
    P0761Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human C4bp
    Cat.:
    P0761Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human C4bp
    Monoclonal Antibody for Human C4bp
    Monoclonal Antibody for Human C4bp
    Monoclonal Antibody for Human C4bp
    Monoclonal Antibody for Human C4bp
    Protein for Human C4bp
    Protein for Human C4bp
    Protein for Human C4bp
    Cat.:
    R0761h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human C4bp

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    References
    1. 1.
      "Molecular cloning of the cDNA coding for proline-rich protein (PRP): identity of PRP as C4b-binding protein."
      Matsuguchi T. , Okamura S. , Aso T. , Sata T. , Niho Y.
      Biochem. Biophys. Res. Commun.165:138-144(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    2. 2.
      "Genomic organization of the alpha chain of the human C4b-binding protein gene."
      Aso T. , Okamura S. , Matsuguchi T. , Sakamoto N. , Sata T. , Niho Y.
      Biochem. Biophys. Res. Commun.174:222-227(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    6. 6.
      "Derivation of the sequence of the signal peptide in human C4b-binding protein and interspecies cross-hybridisation of the C4bp cDNA sequence."
      Lintin S.J. , Lewin A.R. , Reid K.B.M.
      FEBS Lett.232:328-332(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-81
    7. 7.
      "Studies on the structure of the human C4b-binding protein gene."
      Lintin S.J. , Reid K.B.M.
      FEBS Lett.204:77-81(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 203-288
    8. 8.
      "Molecular cloning and characterization of the cDNA coding for C4b-binding protein, a regulatory protein of the classical pathway of the human complement system."
      Chung L.P. , Bentley D.R. , Reid K.B.M.
      Biochem. J.230:133-141(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-597
    9. 9.
      "Amino acid sequence studies of human C4b-binding protein: N-terminal sequence analysis and alignment of the fragments produced by limited proteolysis with chymotrypsin and the peptides produced by cyanogen bromide treatment."
      Chung L.P. , Gagnon J. , Reid K.B.M.
      Mol. Immunol.22:427-435(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 49-88
    10. 10.
      "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry."
      Bunkenborg J. , Pilch B.J. , Podtelejnikov A.V. , Wisniewski J.R.
      Proteomics4:454-465(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-506 AND ASN-528
      tissue: Plasma.
    11. 11.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-221 AND ASN-506
      tissue: Plasma.
    12. 12.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-221 AND ASN-506
      tissue: Liver.
    13. 13.
      "Visualization of human C4b-binding protein and its complexes with vitamin K-dependent protein S and complement protein C4b."
      Dahlback B. , Smith C.A. , Mueller-Eberhard H.J.
      Proc. Natl. Acad. Sci. U.S.A.80:3461-3465(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY ELECTRON MICROSCOPY;LIGAND-BINDING
    14. 14.
      "Human C4b-binding protein, structural basis for interaction with streptococcal M protein, a major bacterial virulence factor."
      Jenkins H.T. , Mark L. , Ball G. , Persson J. , Lindahl G. , Uhrin D. , Blom A.M. , Barlow P.N.
      J. Biol. Chem.281:3690-3697(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 49-172;DISULFIDE BONDS
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