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Index > Protein center > CABIN1(Gene name) > Human
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  • CABIN1 (Gene name),
  • Calcineurin-binding protein cabin-1 (Protein name ),  CABIN_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    CABIN1(KIAA0330);
    Protein name:
    Calcineurin-binding protein cabin-1;
    Alternative:
    Calcineurin inhibitor(CAIN);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with calcineurin. Interacts with MEF2B.
    Function:
    May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    2220
    Sequence:
    50:
    MIRIAALNAS | STIEDDHEGS | FKSHKTQTKE | AQEAEAFALY | HKALDLQKHD | 
    100:
    RFEESAKAYH | ELLEASLLRE | AVSSGDEKEG | LKHPGLILKY | STYKNLAQLA | 
    150:
    AQREDLETAM | EFYLEAVMLD | STDVNLWYKI | GHVALRLIRI | PLARHAFEEG | 
    200:
    LRCNPDHWPC | LDNLITVLYT | LSDYTTCLYF | ICKALEKDCR | YSKGLVLKEK | 
    250:
    IFEEQPCLRK | DSLRMFLKCD | MSIHDVSVSA | AETQAIVDEA | LGLRKKRQAL | 
    300:
    IVREKEPDLK | LVQPIPFFTW | KCLGESLLAM | YNHLTTCEPP | RPSLGKRIDL | 
    350:
    SDYQDPSQPL | ESSMVVTPVN | VIQPSTVSTN | PAVAVAEPVV | SYTSVATTSF | 
    400:
    PLHSPGLLET | GAPVGDISGG | DKSKKGVKRK | KISEESGETA | KRRSARVRNT | 
    450:
    KCKKEEKVDF | QELLMKFLPS | RLRKLDPEEE | DDSFNNYEVQ | SEAKLESFPS | 
    500:
    IGPQRLSFDS | ATFMESEKQD | VHEFLLENLT | NGGILELMMR | YLKAMGHKFL | 
    550:
    VRWPPGLAEV | VLSVYHSWRR | HSTSLPNPLL | RDCSNKHIKD | MMLMSLSCME | 
    600:
    LQLDQWLLTK | GRSSAVSPRN | CPAGMVNGRF | GPDFPGTHCL | GDLLQLSFAS | 
    650:
    SQRDLFEDGW | LEFVVRVYWL | KARFLALQGD | MEQALENYDI | CTEMLQSSTA | 
    700:
    IQVEAGAERR | DIVIRLPNLH | NDSVVSLEEI | DKNLKSLERC | QSLEEIQRLY | 
    750:
    EAGDYKAVVH | LLRPTLCTSG | FDRAKHLEFM | TSIPERPAQL | LLLQDSLLRL | 
    800:
    KDYRQCFECS | DVALNEAVQQ | MVNSGEAAAK | EEWVATVTQL | LMGIEQALSA | 
    850:
    DSSGSILKVS | SSTTGLVRLT | NNLIQVIDCS | MAVQEEAKEP | HVSSVLPWII | 
    900:
    LHRIIWQEED | TFHSLCHQQQ | LQNPAEEGMS | ETPMLPSSLM | LLNTAHEYLG | 
    950:
    RRSWCCNSDG | ALLRFYVRVL | QKELAASTSE | DTHPYKEELE | TALEQCFYCL | 
    1000:
    YSFPSKKSKA | RYLEEHSAQQ | VDLIWEDALF | MFEYFKPKTL | PEFDSYKTST | 
    1050:
    VSADLANLLK | RIATIVPRTE | RPALSLDKVS | AYIEGTSTEV | PCLPEGADPS | 
    1100:
    PPVVNELYYL | LADYHFKNKE | QSKAIKFYMH | DICICPNRFD | SWAGMALARA | 
    1150:
    SRIQDKLNSN | ELKSDGPIWK | HATPVLNCFR | RALEIDSSNL | SLWIEYGTMS | 
    1200:
    YALHSFASRQ | LKQWRGELPP | ELVQQMEGRR | DSMLETAKHC | FTSAARCEGD | 
    1250:
    GDEEEWLIHY | MLGKVAEKQQ | QPPTVYLLHY | RQAGHYLHEE | AARYPKKIHY | 
    1300:
    HNPPELAMEA | LEVYFRLHAS | ILKLLGKPDS | GVGAEVLVNF | MKEAAEGPFA | 
    1350:
    RGEEKNTPKA | SEKEKACLVD | EDSHSSAGTL | PGPGASLPSS | SGPGLTSPPY | 
    1400:
    TATPIDHDYV | KCKKPHQQAT | PDDRSQDSTA | VALSDSSSTQ | DFFNEPTSLL | 
    1450:
    EGSRKSYTEK | RLPILSSQAG | ATGKDLQGAT | EERGKNEESL | ESTEGFRAAE | 
    1500:
    QGVQKPAAET | PASACIPGKP | SASTPTLWDG | KKRGDLPGEP | VAFPQGLPAG | 
    1550:
    AEEQRQFLTE | QCIASFRLCL | SRFPQHYKSL | YRLAFLYTYS | KTHRNLQWAR | 
    1600:
    DVLLGSSIPW | QQLQHMPAQG | LFCERNKTNF | FNGIWRIPVD | EIDRPGSFAW | 
    1650:
    HMNRSIVLLL | KVLAQLRDHS | TLLKVSSMLQ | RTPDQGKKYL | RDADRQVLAQ | 
    1700:
    RAFILTVKVL | EDTLSELAEG | SERPGPKVCG | LPGARMTTDV | SHKASPEDGQ | 
    1750:
    EGLPQPKKPP | LADGSGPGPE | PGGKVGLLNH | RPVAMDAGDS | ADQSGERKDK | 
    1800:
    ESPRAGPTEP | MDTSEATVCH | SDLERTPPLL | PGRPARDRGP | ESRPTELSLE | 
    1850:
    ELSISARQQP | TPLTPAQPAP | APAPATTTGT | RAGGHPEEPL | SRLSRKRKLL | 
    1900:
    EDTESGKTLL | LDAYRVWQQG | QKGVAYDLGR | VERIMSETYM | LIKQVDEEAA | 
    1950:
    LEQAVKFCQV | HLGAAAQRQA | SGDTPTTPKH | PKDSRENFFP | VTVVPTAPDP | 
    2000:
    VPADSVQRPS | DAHTKPRPAL | AAATTIITCP | PSASASTLDQ | SKDPGPPRPH | 
    2050:
    RPEATPSMAS | LGPEGEELAR | VAEGTSFPPQ | EPRHSPQVKM | APTSSPAEPH | 
    2100:
    CWPAEAALGT | GAEPTCSQEG | KLRPEPRRDG | EAQEAASETQ | PLSSPPTAAS | 
    2150:
    SKAPSSGSAQ | PPEGHPGKPE | PSRAKSRPLP | NMPKLVIPSA | ATKFPPEITV | 
    2200:
    TPPTPTLLSP | KGSISEETKQ | KLKSAILSAQ | SAANVRKESL | CQPALEVLET | 
    2220:
    SSQESSLESE | TDEDDDYMDI | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    MIM:
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Calcineurin-binding protein cabin-1
    Cat.:
    E6266h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Calcineurin-binding protein cabin-1
    Cat.:
    E6266r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Calcineurin-binding protein cabin-1
    Cat.:
    U6266h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Calcineurin-binding protein cabin-1
    Cat.:
    U6266r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Calcineurin-binding protein cabin-1
    Cat.:
    P6266Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Calcineurin-binding protein cabin-1
    Monoclonal Antibody for Human Calcineurin-binding protein cabin-1
    Monoclonal Antibody for Human Calcineurin-binding protein cabin-1
    Protein for Human Calcineurin-binding protein cabin-1
    Protein for Human Calcineurin-binding protein cabin-1

    R&D Technical Data

    s

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    s
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤7.3%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤12.3%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    97

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-102%

    90-104%

    95-100%

    91-103%

    EDTA plasma(n=5)

    89-107%

    93-105%

    91-106%

    90-108%

    heparin plasma(n=5)

    93-104%

     

    94-101%

    95-101%

    91-105%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes."
      Sun L. , Youn H.-D. , Loh C. , Stolow M. , He W. , Liu J.O.
      Immunity8:703-711(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH CALCINEURIN;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION
      tissue: Kidney.
    2. 2.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT GLN-853
      tissue: Testis.
    5. 5.
      "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Nakajima D. , Ohira M. , Seki N. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 319-2220 (ISOFORM 1)
      tissue: Brain.
    6. 6.
      "Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis."
      Tagami H. , Ray-Gallet D. , Almouzni G. , Nakatani Y.
      Cell116:51-61(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN A COMPLEX WITH ASF1A; HIRA; HISTONE H3.3 AND UBN1
    7. 7.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    8. 8.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-2151 AND THR-2154;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-66 AND SER-1439;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Phosphorylation and ubiquitination-dependent degradation of CABIN1 releases p53 for transactivation upon genotoxic stress."
      Choi S.Y. , Jang H. , Roe J.S. , Kim S.T. , Cho E.J. , Youn H.D.
      Nucleic Acids Res.41:2180-2190(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY ATM AND CHK2;UBIQUITINATION
    11. 11.
      "Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2."
      Han A. , Pan F. , Stroud J.C. , Youn H.-D. , Liu J.O. , Chen L.
      Nature422:730-734(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 2156-2190 IN COMPLEX WITH MEF2B AND DNA;MUTAGENESIS OF LEU-2172
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