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Index > Protein center > CA14(Gene name) > Human
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  • CA14 (Gene name),
  • Carbonic anhydrase 14 (Protein name ),  CAH14_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CA14(UNQ690/PRO1335);
    Protein name:
    Carbonic anhydrase 14;
    Alternative:
    Carbonic anhydrase XIV(CA-XIV);Carbonate dehydratase XIV;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Reversible hydration of carbon dioxide.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    337
    Sequence:
    50:
    MLFSALLLEV | IWILAADGGQ | HWTYEGPHGQ | DHWPASYPEC | GNNAQSPIDI | 
    100:
    QTDSVTFDPD | LPALQPHGYD | QPGTEPLDLH | NNGHTVQLSL | PSTLYLGGLP | 
    150:
    RKYVAAQLHL | HWGQKGSPGG | SEHQINSEAT | FAELHIVHYD | SDSYDSLSEA | 
    200:
    AERPQGLAVL | GILIEVGETK | NIAYEHILSH | LHEVRHKDQK | TSVPPFNLRE | 
    250:
    LLPKQLGQYF | RYNGSLTTPP | CYQSVLWTVF | YRRSQISMEQ | LEKLQGTLFS | 
    300:
    TEEEPSKLLV | QNYRALQPLN | QRMVFASFIQ | AGSSYTTGEM | LSLGVGILVG | 
    337:
    CLCLLLAVYF | IARKIRKKRL | ENRKSVVFTS | AQATTEA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    UniGene:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Carbonic anhydrase 14
    Cat.:
    E1424h
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    96T
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    ELISA Kit for Human Carbonic anhydrase 14
    Cat.:
    E1424m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Carbonic anhydrase 14
    Cat.:
    U1424m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Carbonic anhydrase 14
    Cat.:
    U1424h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Carbonic anhydrase 14
    Cat.:
    P1424Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Carbonic anhydrase 14
    Cat.:
    P1424Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Carbonic anhydrase 14
    Monoclonal Antibody for Human Carbonic anhydrase 14
    Protein for Human Carbonic anhydrase 14
    Protein for Human Carbonic anhydrase 14

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Human carbonic anhydrase XIV (CA14): cDNA cloning, mRNA expression, and mapping to chromosome 1."
      Fujikawa-Adachi K. , Nishimori I. , Taguchi T. , Onishi S.
      Genomics61:74-81(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Lung.
      tissue: Testis.
    7. 7.
      "Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme."
      Temperini C. , Scozzafava A. , Vullo D. , Supuran C.T.
      Chemistry12:7057-7066(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    8. 8.
      "Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design."
      Temperini C. , Scozzafava A. , Vullo D. , Supuran C.T.
      J. Med. Chem.49:3019-3027(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    9. 9.
      "Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste."
      Koehler K. , Hillebrecht A. , Schulze Wischeler J. , Innocenti A. , Heine A. , Supuran C.T. , Klebe G.
      Angew. Chem. Int. Ed. Engl.46:7697-7699(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    10. 10.
      "Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV."
      Temperini C. , Innocenti A. , Scozzafava A. , Mastrolorenzo A. , Supuran C.T.
      Bioorg. Med. Chem. Lett.17:628-635(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    11. 11.
      "Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."
      Temperini C. , Innocenti A. , Guerri A. , Scozzafava A. , Rusconi S. , Supuran C.T.
      Bioorg. Med. Chem. Lett.17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    12. 12.
      "A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."
      Crocetti L. , Maresca A. , Temperini C. , Hall R.A. , Scozzafava A. , Muehlschlegel F.A. , Supuran C.T.
      Bioorg. Med. Chem. Lett.19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    13. 13.
      "Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."
      Maresca A. , Temperini C. , Vu H. , Pham N.B. , Poulsen S.-A. , Scozzafava A. , Quinn R.J. , Supuran C.T.
      J. Am. Chem. Soc.131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
    14. 14.
      "Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide."
      Di Fiore A. , Monti S.M. , Hilvo M. , Parkkila S. , Romano V. , Scaloni A. , Pedone C. , Scozzafava A. , Supuran C.T. , De Simone G.
      Proteins74:164-175(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION
    15. 15.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-325;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors."
      Alterio V. , Pan P. , Parkkila S. , Buonanno M. , Supuran C.T. , Monti S.M. , De Simone G.
      Biopolymers101:769-778(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 16-290;ZINC-BINDING SITES;GLYCOSYLATION AT ASN-213;DISULFIDE BOND
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