CA2 ELISA Kit for Human(Homo sapiens) | EIAab.comCA2 ELISA Kit for Human(Homo sapiens)

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CA2 (Gene name),

Carbonic anhydrase 2 (Protein name ), CAH2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

CA2;

Protein name:

Carbonic anhydrase 2;

Alternative:

Carbonic anhydrase C(CAC);Carbonate dehydratase II;Carbonic anhydrase II(CA-II);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity.

Function:

Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

260

Sequence:

50:

100:

150:

200:

250:

260:

KNRQIKASFK |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P00918

STRING:

9606.ENSP00000285379

MIM:

259730

SMR:

P00918

UniGene:

Hs.155097

KEGG:

hsa:760

Pfam:

PF00194

Uniprot:

P00918

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ELISA Kit for Human Carbonic anhydrase 2

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E0782r

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96T

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ELISA Kit for Human Carbonic anhydrase 2

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E0782b

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96T

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ELISA Kit for Human Carbonic anhydrase 2

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E0782c

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96T

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ELISA Kit for Human Carbonic anhydrase 2

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ELISA Kit for Human Carbonic anhydrase 2

MSDS:

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ELISA Kit for Human Carbonic anhydrase 2

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E0782m

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96T

CLIA Kit for Human Carbonic anhydrase 2

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CLIA Kit for Human Carbonic anhydrase 2

Cat.:

U0782c

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96T

CLIA Kit for Human Carbonic anhydrase 2

Cat.:

U0782m

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96T

CLIA Kit for Human Carbonic anhydrase 2

Cat.:

U0782r

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96T

CLIA Kit for Human Carbonic anhydrase 2

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U0782h

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96T

CLIA Kit for Human Carbonic anhydrase 2

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U0782b

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96T

Polyclonal Antibody for Human Carbonic anhydrase 2

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P0782Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Carbonic anhydrase 2

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P0782Rb-r

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Polyclonal Antibody for Human Carbonic anhydrase 2

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P0782Rb-h

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Polyclonal Antibody for Human Carbonic anhydrase 2

Monoclonal Antibody for Human Carbonic anhydrase 2

Protein for Human Carbonic anhydrase 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Nucleotide sequence of human liver carbonic anhydrase II cDNA."
Montgomery J.C. , Venta P.J. , Tashian R.E. , Hewett-Emmett D.
Nucleic Acids Res.15:4687-4687(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Cloning, expression, and sequence homologies of cDNA for human carbonic anhydrase II."
Murakami H. , Marelich G.P. , Grubb J.H. , Kyle J.W. , Sly W.S.
Genomics1:159-166(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Urinary bladder.
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Ovary.
7.

"Human carbonic anhydrases. XII. The complete primary structure of the C isozyme."
Lin K.-T.D. , Deutsch H.F.
J. Biol. Chem.249:2329-2337(1974) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-260;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2
8.

"Primary structure of human carbonic anhydrase C."
Henderson L.E. , Henriksson D. , Nyman P.O.
J. Biol. Chem.251:5457-5463(1976) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-260
9.

"Comparison of the 5' regions of human and mouse carbonic anhydrase II genes and identification of possible regulatory elements."
Venta P.J. , Montgomery J.C. , Hewett-Emmett D. , Tashian R.E.
Biochim. Biophys. Acta826:195-201(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-77
10.

"Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter."
Alvarez B.V. , Loiselle F.B. , Supuran C.T. , Schwartz G.J. , Casey J.R.
Biochemistry42:12321-12329(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC4A4
11.

"Regulation of the human NBC3 Na+/HCO3- cotransporter by carbonic anhydrase II and PKA."
Loiselle F.B. , Morgan P.E. , Alvarez B.V. , Casey J.R.
Am. J. Physiol.286:C1423-C1433(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC4A7
12.

"Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells."
Pushkin A. , Abuladze N. , Gross E. , Newman D. , Tatishchev S. , Lee I. , Fedotoff O. , Bondar G. , Azimov R. , Ngyuen M. , Kurtz I.
J. Physiol. (Lond.)559:55-65(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC4A4
13.

"Metabolon disruption: a mechanism that regulates bicarbonate transport."
Alvarez B.V. , Vilas G.L. , Casey J.R.
EMBO J.24:2499-2511(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SLC26A6;SUBCELLULAR LOCATION
14.

"Phosph(on)ate as a zinc-binding group in metalloenzyme inhibitors: X-ray crystal structure of the antiviral drug foscarnet complexed to human carbonic anhydrase I."
Temperini C. , Innocenti A. , Guerri A. , Scozzafava A. , Rusconi S. , Supuran C.T.
Bioorg. Med. Chem. Lett.17:2210-2215(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ENZYME REGULATION
15.

"Crystal structure of human carbonic anhydrase XIII and its complex with the inhibitor acetazolamide."
Di Fiore A. , Monti S.M. , Hilvo M. , Parkkila S. , Romano V. , Scaloni A. , Pedone C. , Scozzafava A. , Supuran C.T. , De Simone G.
Proteins74:164-175(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION
16.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
17.

"Crystal structure of human carbonic anhydrase C."
Liljas A. , Kannan K.K. , Bergsten P.-C. , Waara I. , Fridborg K. , Strandberg B. , Carlbom U. , Jaerup L. , Loevgren S. , Petef M.
Nature New Biol.235:131-137(1972) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS)
18.

"Refined structure of human carbonic anhydrase II at 2.0-A resolution."
Eriksson A.E. , Jones T.A. , Liljas A.
Proteins4:274-282(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ZINC ION
19.

"Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: a pentacoordinated binding of the SCN-ion to the zinc at high pH."
Eriksson A.E. , Kylsten P.M. , Jones T.A. , Liljas A.
Proteins4:283-293(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH ZINC ION AND INHIBITORS
20.

"Conformational mobility of His-64 in the Thr-200TO: human carbonic anhydrase II."
Krebs J.F. , Fierke C.A. , Alexander R.S. , Christianson D.W.
Biochemistry30:9153-9160(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF MUTANT SER-199 IN COMPLEX WITH ZINC ION;MUTAGENESIS OF THR-199;BIOPHYSICOCHEMICAL PROPERTIES
21.

"Engineering the hydrophobic pocket of carbonic anhydrase II."
Alexander R.S. , Nair S.K. , Christianson D.W.
Biochemistry30:11064-11072(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF MUTANTS PHE-142; TYR-142 AND HIS-142 IN COMPLEX WITH INHIBITORS;MUTAGENESIS OF VAL-142
22.

"Altering the mouth of a hydrophobic pocket. Structure and kinetics of human carbonic anhydrase II mutants at residue Val-121."
Nair S.K. , Calderone T.L. , Christianson D.W. , Fierke C.A.
J. Biol. Chem.266:17320-17325(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF MUTANT ALA-121;MUTAGENESIS OF VAL-121;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
23.

"Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic anhydrase using hydrogen sulphide and nitrate anions."
Mangani S. , Haakansson K.
Eur. J. Biochem.210:867-871(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH ZINC ION AND INHIBITORS;ENZYME REGULATION
24.

"Structure of native and apo carbonic anhydrase II and structure of some of its anion-ligand complexes."
Haakansson K. , Carlsson M. , Svensson L.A. , Liljas A.
J. Mol. Biol.227:1192-1204(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.54 ANGSTROMS) IN COMPLEX WITH ZINC ION AND INHIBITORS
25.

"Structure of cobalt carbonic anhydrase complexed with bicarbonate."
Haakansson K. , Wehnert A.
J. Mol. Biol.228:1212-1218(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.88 ANGSTROMS) IN COMPLEX WITH COBALT ION AND BICARBONATE
26.

"Engineering the zinc binding site of human carbonic anhydrase II: structure of the His-94-->Cys apoenzyme in a new crystalline form."
Alexander R.S. , Kiefer L.L. , Fierke C.A. , Christianson D.W.
Biochemistry32:1510-1518(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF MUTANT CYS-94 IN COMPLEX WITH ZINC ION;MUTAGENESIS OF HIS-94
27.

"Structural consequences of hydrophilic amino acid substitutions in the hydrophobic pocket of human carbonic anhydrase II."
Nair S.K. , Christianson D.W.
Biochemistry32:4506-4514(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF MUTANT ALA-197; GLU-197; HIS-197 AND ARG-197;MUTAGENESIS OF LEU-197
28.

"Structure of an engineered His3Cys zinc binding site in human carbonic anhydrase II."
Ippolito J.A. , Christianson D.W.
Biochemistry32:9901-9905(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF MUTANT CYS-198 IN COMPLEX WITH ZINC ION;MUTAGENESIS OF THR-198
29.

"Structure and energetics of a non-proline cis-peptidyl linkage in a proline-202-->alanine carbonic anhydrase II variant."
Tweedy N.B. , Nair S.K. , Paterno S.A. , Fierke C.A. , Christianson D.W.
Biochemistry32:10944-10949(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF MUTANT ALA-201 IN COMPLEX WITH ZINC ION;MUTAGENESIS OF PRO-201
30.

"The structure of human carbonic anhydrase II in complex with bromide and azide."
Joensson B.M. , Haakansson K. , Liljas A.
FEBS Lett.322:186-190(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH ZINC ION AND INHIBITORS
31.

"Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II."
Krebs J.F. , Ippolito J.A. , Christianson D.W. , Fierke C.A.
J. Biol. Chem.268:27458-27466(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF MUTANT VAL-198 IN COMPLEX WITH ZINC ION AND INHIBITORS;MUTAGENESIS OF THR-198;BIOPHYSICOCHEMICAL PROPERTIES
32.

"Crystal structure of the complex between human carbonic anhydrase II and the aromatic inhibitor 1,2,4-triazole."
Mangani S. , Liljas A.
J. Mol. Biol.232:9-14(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH INHIBITOR AND ZINC ION
33.

"Crystallographic analysis of Thr-200-->His human carbonic anhydrase II and its complex with the substrate, HCO3-."
Xue Y. , Vidgren J. , Svensson L.A. , Liljas A. , Jonsson B.H. , Lindskog S.
Proteins15:80-87(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF MUTANT HIS-199 IN COMPLEX WITH BICARBONATE AND ZINC ION;MUTAGENESIS OF THR-199
34.

"Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II."
Xue Y. , Liljas A. , Jonsson B.H. , Lindskog S.
Proteins17:93-106(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF MUTANTS IN COMPLEX WITH BICARBONATE AND ZINC ION;MUTAGENESIS OF GLU-106 AND THR-198
35.

"X-ray analysis of metal-substituted human carbonic anhydrase II derivatives."
Haakansson K. , Wehnert A. , Liljas A.
Acta Crystallogr. D50:93-100(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH COBALT; COPPER; NICKEL AND MANGANESE IONS
36.

"Wild-type and E106Q mutant carbonic anhydrase complexed with acetate."
Haakansson K. , Briand C. , Zaitsev V. , Xue Y. , Liljas A.
Acta Crystallogr. D50:101-104(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) MUTANT GLN-106 IN COMPLEX WITH THE INHIBITOR ACETATE;MUTAGENESIS OF GLU-106
37.

"Structural consequences of redesigning a protein-zinc binding site."
Ippolito J.A. , Christianson D.W.
Biochemistry33:15241-15249(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 2-259 OF MUTANTS ALA-94; CYS-94; CYS-96; CYS-119 AND ASP-119 IN COMPLEX WITH ZINC ION
38.

"The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide."
Haakansson K. , Liljas A.
FEBS Lett.350:319-322(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH THE INHIBITOR TRIFLUOROMETHANE SULPHONAMIDE
39.

"Positions of His-64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors."
Smith G.M. , Alexander R.S. , Christianson D.W. , McKeever B.M. , Ponticello G.S. , Springer J.P. , Randall W.C. , Baldwin J.J. , Habecker C.N.
Protein Sci.3:118-125(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH INHIBITORS
40.

"Structural basis of inhibitor affinity to variants of human carbonic anhydrase II."
Nair S.K. , Krebs J.F. , Christianson D.W. , Fierke C.A.
Biochemistry34:3981-3989(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF MUTANTS ARG-197; ASP-197 AND PHE-197 IN COMPLEX WITH THE INHIBITOR ACETAZOLAMIDE
41.

"Secondary interactions significantly removed from the sulfonamide binding pocket of carbonic anhydrase II influence inhibitor binding constants."
Boriack P.A. , Christianson D.W. , Kingery-Wood J. , Whitesides G.M.
J. Med. Chem.38:2286-2291(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH INHIBITORS
42.

"Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity."
Ippolito J.A. , Baird T.T. Jr. , McGee S.A. , Christianson D.W. , Fierke C.A.
Proc. Natl. Acad. Sci. U.S.A.92:5017-5021(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF MUTANTS ASP-198; GLU-198 AND HIS-198 IN COMPLEX WITH ZINC ION;MUTAGENESIS OF THR-198;BIOPHYSICOCHEMICAL PROPERTIES
43.

"Reversal of the hydrogen bond to zinc ligand histidine-119 dramatically diminishes catalysis and enhances metal equilibration kinetics in carbonic anhydrase II."
Huang C.C. , Lesburg C.A. , Kiefer L.L. , Fierke C.A. , Christianson D.W.
Biochemistry35:3439-3446(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF THE MUTANT GLN-117 IN COMPLEX WITH ZINC ION AND THE INHIBITOR ACETAZOLAMIDE;MUTAGENESIS OF GLU-117
44.

"X-ray crystallographic studies of alanine-65 variants of carbonic anhydrase II reveal the structural basis of compromised proton transfer in catalysis."
Scolnick L.R. , Christianson D.W.
Biochemistry35:16429-16434(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF MUTANTS GLY-65; HIS-65; LEU-65; PHE-65; SER-65 AND THR-65 IN COMPLEX WITH ZINC ION
45.

"Unexpected binding mode of the sulfonamide fluorophore 5-dimethylamino-1-naphthalene sulfonamide to human carbonic anhydrase II. Implications for the development of a zinc biosensor."
Nair S.K. , Elbaum D. , Christianson D.W.
J. Biol. Chem.271:1003-1007(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH THE INHIBITOR DANSYLAMIDE
46.

"Carbonic anhydrase activators: X-ray crystallographic and spectroscopic investigations for the interaction of isozymes I and II with histamine."
Briganti F. , Mangani S. , Orioli P. , Scozzafava A. , Vernaglione G. , Supuran C.T.
Biochemistry36:10384-10392(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH THE ACTIVATOR HISTAMINE;ENZYME REGULATION
47.

"Histidine --> carboxamide ligand substitutions in the zinc binding site of carbonic anhydrase II alter metal coordination geometry but retain catalytic activity."
Lesburg C.A. , Huang C. , Christianson D.W. , Fierke C.A.
Biochemistry36:15780-15791(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF MUTANTS ASN-94; ASN-119 AND GLN-119 IN COMPLEX WITH ZINC ION;MUTAGENESIS OF HIS-94 AND HIS-119;BIOPHYSICOCHEMICAL PROPERTIES
48.

"Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination."
Stams T. , Chen Y. , Boriack-Sjodin P.A. , Hurt J.D. , Liao J. , May J.A. , Dean T. , Laipis P. , Silverman D.N. , Christianson D.W.
Protein Sci.7:556-563(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEX WITH THE INHIBITOR BRINZOLAMIDE
49.

"Structural analysis of inhibitor binding to human carbonic anhydrase II."
Boriack-Sjodin P.A. , Zeitlin S. , Chen H.H. , Crenshaw L. , Gross S. , Dantanarayana A. , Delgado P. , May J.A. , Dean T. , Christianson D.W.
Protein Sci.7:2483-2489(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH SULFONAMIDE INHIBITORS AND ZINC ION
50.

"Carbonic anhydrase catalyzes cyanamide hydration to urea: is it mimicking the physiological reaction?"
Briganti F. , Mangani S. , Scozzafava A. , Vernaglione G. , Supuran C.T.
J. Biol. Inorg. Chem.4:528-536(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH CYANAMIDE AND SUBSTRATE;FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES
51.

"Mechanism of cyanamide hydration catalyzed by carbonic anhydrase II suggested by cryogenic X-ray diffraction."
Guerri A. , Briganti F. , Scozzafava A. , Supuran C.T. , Mangani S.
Biochemistry39:12391-12397(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH CYANAMIDE
52.

"Structural influence of hydrophobic core residues on metal binding and specificity in carbonic anhydrase II."
Cox J.D. , Hunt J.A. , Compher K.M. , Fierke C.A. , Christianson D.W.
Biochemistry39:13687-13694(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) OF MUTANTS ILE-93/MET-95/VAL-97 AND SER-93/LEU-95/MET-97 IN COMPLEX WITH COBALT; COPPER AND ZINC IONS
53.

"Structural and kinetic analysis of the chemical rescue of the proton transfer function of carbonic anhydrase II."
Duda D. , Tu C. , Qian M. , Laipis P. , Agbandje-McKenna M. , Silverman D.N. , McKenna R.
Biochemistry40:1741-1748(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF THE MUTANT ALA-64 IN COMPLEX WITH 4-METHYLIMIDAZOLE;MUTAGENESIS OF HIS-64
54.

"Fluoroaromatic-fluoroaromatic interactions between inhibitors bound in the crystal lattice of human carbonic anhydrase II."
Kim C.Y. , Chandra P.P. , Jain A. , Christianson D.W.
J. Am. Chem. Soc.123:9620-9627(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF MUTANT VAL-130 IN COMPLEX WITH FLUOROAROMATIC INHIBITORS
55.

"Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate."
Recacha R. , Costanzo M.J. , Maryanoff B.E. , Chattopadhyay D.
Biochem. J.361:437-441(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH THE INHIBITOR SUGAR SULFAMATE RWJ-37497;ENZYME REGULATION
56.

"Organization of an efficient carbonic anhydrase: implications for the mechanism based on structure-function studies of a T199P/C206S mutant."
Huang S. , Sjoeblom B. , Sauer-Eriksson A.E. , Jonsson B.H.
Biochemistry41:7628-7635(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF THE MUTANT PRO-198/SER-205 IN COMPLEX WITH BICARBONATE AND INHIBITORS;MUTAGENESIS OF THR-198
57.

"Kinetic analysis of multiple proton shuttles in the active site of human carbonic anhydrase."
Tu C. , Qian M. , An H. , Wadhwa N.R. , Duda D. , Yoshioka C. , Pathak Y. , McKenna R. , Laipis P.J. , Silverman D.N.
J. Biol. Chem.277:38870-38876(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF THE MUTANT HIS-7;MUTAGENESIS OF TYR-7
58.

"Structural aspects of isozyme selectivity in the binding of inhibitors to carbonic anhydrases II and IV."
Kim C.Y. , Whittington D.A. , Chang J.S. , Liao J. , May J.A. , Christianson D.W.
J. Med. Chem.45:888-893(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.93 ANGSTROMS) IN COMPLEX WITH INHIBITORS;FUNCTION
59.

"Successful virtual screening for novel inhibitors of human carbonic anhydrase: strategy and experimental confirmation."
Grueneberg S. , Stubbs M.T. , Klebe G.
J. Med. Chem.45:3588-3602(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEX WITH INHIBITORS
60.

"Combinatorial computational method gives new picomolar ligands for a known enzyme."
Grzybowski B.A. , Ishchenko A.V. , Kim C.Y. , Topalov G. , Chapman R. , Christianson D.W. , Whitesides G.M. , Shakhnovich E.I.
Proc. Natl. Acad. Sci. U.S.A.99:1270-1273(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.94 ANGSTROMS) IN COMPLEX WITH INHIBITORS
61.

"The refined atomic structure of carbonic anhydrase II at 1.05 A resolution: implications of chemical rescue of proton transfer."
Duda D. , Govindasamy L. , Agbandje-McKenna M. , Tu C. , Silverman D.N. , McKenna R.
Acta Crystallogr. D59:93-104(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS) OF THE MUTANT ALA-64 IN COMPLEX WITH THE INHIBITOR 4-METHYLIMIDAZOLE AND ZINC ION
62.

"Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition."
Weber A. , Casini A. , Heine A. , Kuhn D. , Supuran C.T. , Scozzafava A. , Klebe G.
J. Med. Chem.47:550-557(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH INHIBITORS;ENZYME REGULATION
63.

"Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent."
Lloyd M.D. , Pederick R.L. , Natesh R. , Woo L.W. , Purohit A. , Reed M.J. , Acharya K.R. , Potter B.V.
Biochem. J.385:715-720(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH THE ANTI-CANCER AGENT 667-COUMATE
64.

"Structural and kinetic characterization of active-site histidine as a proton shuttle in catalysis by human carbonic anhydrase II."
Fisher Z. , Hernandez Prada J.A. , Tu C. , Duda D. , Yoshioka C. , An H. , Govindasamy L. , Silverman D.N. , McKenna R.
Biochemistry44:1097-1105(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS);MUTAGENESIS OF ASN-62; HIS-64 AND ASN-67;BIOPHYSICOCHEMICAL PROPERTIES
65.

"First crystal structures of human carbonic anhydrase II in complex with dual aromatase-steroid sulfatase inhibitors."
Lloyd M.D. , Thiyagarajan N. , Ho Y.T. , Woo L.W. , Sutcliffe O.B. , Purohit A. , Reed M.J. , Acharya K.R. , Potter B.V.
Biochemistry44:6858-6866(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) IN COMPLEX WITH DUAL AROMATASE-STEROID SULFATASE INHIBITORS
66.

"Carbonic anhydrase activators: X-ray crystal structure of the adduct of human isozyme II with L-histidine as a platform for the design of stronger activators."
Temperini C. , Scozzafava A. , Puccetti L. , Supuran C.T.
Bioorg. Med. Chem. Lett.15:5136-5141(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH ACTIVATOR L-HISTIDINE;ENZYME REGULATION
67.

"Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant antitumor sulfonamide complexed with isozyme II."
Menchise V. , De Simone G. , Alterio V. , Di Fiore A. , Pedone C. , Scozzafava A. , Supuran C.T.
J. Med. Chem.48:5721-5727(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH INHIBITOR
68.

"Proton transfer in a Thr200His mutant of human carbonic anhydrase II."
Bhatt D. , Tu C. , Fisher S.Z. , Hernandez Prada J.A. , McKenna R. , Silverman D.N.
Proteins61:239-245(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS);MUTAGENESIS OF HIS-64 AND THR-199
69.

"Production and X-ray crystallographic analysis of fully deuterated human carbonic anhydrase II."
Budayova-Spano M. , Fisher S.Z. , Dauvergne M.T. , Agbandje-McKenna M. , Silverman D.N. , Myles D.A. , McKenna R.
Acta Crystallogr. F62:6-9(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS)
70.

"X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes."
Fisher S.Z. , Govindasamy L. , Boyle N. , Agbandje-McKenna M. , Silverman D.N. , Blackburn G.M. , McKenna R.
Acta Crystallogr. F62:618-622(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.15 ANGSTROMS) IN COMPLEX WITH INHIBITORS
71.

"Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib."
Di Fiore A. , Pedone C. , D'Ambrosio K. , Scozzafava A. , De Simone G. , Supuran C.T.
Bioorg. Med. Chem. Lett.16:437-442(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) IN COMPLEX WITH INHIBITORS VALDECOXIB AND CELECOXIB;ENZYME REGULATION
72.

"N-hydroxyurea -- a versatile zinc binding function in the design of metalloenzyme inhibitors."
Temperini C. , Innocenti A. , Scozzafava A. , Supuran C.T.
Bioorg. Med. Chem. Lett.16:4316-4320(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH N-HYDROXYUREA;ENZYME REGULATION
73.

"Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II."
Menchise V. , De Simone G. , Di Fiore A. , Scozzafava A. , Supuran C.T.
Bioorg. Med. Chem. Lett.16:6204-6208(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) IN COMPLEX WITH INHIBITORS
74.

"Carbonic anhydrase activators. Activation of isozymes I, II, IV, VA, VII, and XIV with l- and d-histidine and crystallographic analysis of their adducts with isoform II: engineering proton-transfer processes within the active site of an enzyme."
Temperini C. , Scozzafava A. , Vullo D. , Supuran C.T.
Chemistry12:7057-7066(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH L- AND D-HISTIDINE;ENZYME REGULATION
75.

"Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with 'two-prong' inhibitors reveal the molecular basis of high affinity."
Jude K.M. , Banerjee A.L. , Haldar M.K. , Manokaran S. , Roy B. , Mallik S. , Srivastava D.K. , Christianson D.W.
J. Am. Chem. Soc.128:3011-3018(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (0.99 ANGSTROMS) IN COMPLEX WITH TWO-PRONG INHIBITORS
76.

"Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX."
Alterio V. , Vitale R.M. , Monti S.M. , Pedone C. , Scozzafava A. , Cecchi A. , De Simone G. , Supuran C.T.
J. Am. Chem. Soc.128:8329-8335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.71 ANGSTROMS) IN COMPLEX WITH INHIBITOR
77.

"Carbonic anhydrase activators. Activation of isoforms I, II, IV, VA, VII, and XIV with L- and D-phenylalanine and crystallographic analysis of their adducts with isozyme II: stereospecific recognition within the active site of an enzyme and its consequences for the drug design."
Temperini C. , Scozzafava A. , Vullo D. , Supuran C.T.
J. Med. Chem.49:3019-3027(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH L- AND D-PHENYLALANINE;ENZYME REGULATION
78.

"Carbonic anhydrase inhibitors: Hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX."
De Simone G. , Vitale R.M. , Di Fiore A. , Pedone C. , Scozzafava A. , Montero J.-L. , Winum J.-Y. , Supuran C.T.
J. Med. Chem.49:5544-5551(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH INHIBITOR
79.

"Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue."
Winum J.Y. , Temperini C. , El Cheikh K. , Innocenti A. , Vullo D. , Ciattini S. , Montero J.-L. , Scozzafava A. , Supuran C.T.
J. Med. Chem.49:7024-7031(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH INHIBITOR
80.

"2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity."
Leese M.P. , Leblond B. , Smith A. , Newman S.P. , Di Fiore A. , De Simone G. , Supuran C.T. , Purohit A. , Reed M.J. , Potter B.V.
J. Med. Chem.49:7683-7696(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) IN COMPLEX WITH INHIBITORS
81.

"Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste."
Koehler K. , Hillebrecht A. , Schulze Wischeler J. , Innocenti A. , Heine A. , Supuran C.T. , Klebe G.
Angew. Chem. Int. Ed. Engl.46:7697-7699(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH SACCHARIN;ENZYME REGULATION
82.

"Atomic crystal and molecular dynamics simulation structures of human carbonic anhydrase II: insights into the proton transfer mechanism."
Fisher S.Z. , Maupin C.M. , Budayova-Spano M. , Govindasamy L. , Tu C. , Agbandje-McKenna M. , Silverman D.N. , Voth G.A. , McKenna R.
Biochemistry46:2930-2937(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.05 ANGSTROMS)
83.

"Speeding up proton transfer in a fast enzyme: kinetic and crystallographic studies on the effect of hydrophobic amino acid substitutions in the active site of human carbonic anhydrase II."
Fisher S.Z. , Tu C. , Bhatt D. , Govindasamy L. , Agbandje-McKenna M. , McKenna R. , Silverman D.N.
Biochemistry46:3803-3813(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.15 ANGSTROMS);MUTAGENESIS OF TYR-7; ASN-62 AND ASN-67;BIOPHYSICOCHEMICAL PROPERTIES
84.

"Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV."
Temperini C. , Innocenti A. , Scozzafava A. , Mastrolorenzo A. , Supuran C.T.
Bioorg. Med. Chem. Lett.17:628-635(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH ACTIVATOR L-ADRENALINE;ENZYME REGULATION
85.

"Carbonic anhydrase inhibitors: binding of an antiglaucoma glycosyl-sulfanilamide derivative to human isoform II and its consequences for the drug design of enzyme inhibitors incorporating sugar moieties."
Di Fiore A. , Scozzafava A. , Winum J.-Y. , Montero J.-L. , Pedone C. , Supuran C.T. , De Simone G.
Bioorg. Med. Chem. Lett.17:1726-1731(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) IN COMPLEX WITH INHIBITOR
86.

"Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors."
Temperini C. , Winum J.Y. , Montero J.L. , Scozzafava A. , Supuran C.T.
Bioorg. Med. Chem. Lett.17:2795-2801(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH INHIBITOR N-HYDROXYSULFAMIDE
87.

"Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides -- solution and crystallographic studies."
Alterio V. , De Simone G. , Monti S.M. , Scozzafava A. , Supuran C.T.
Bioorg. Med. Chem. Lett.17:4201-4207(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH INHIBITORS;ENZYME REGULATION
88.

"Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies."
Temperini C. , Innocenti A. , Mastrolorenzo A. , Scozzafava A. , Supuran C.T.
Bioorg. Med. Chem. Lett.17:4866-4872(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH INHIBITORS;ENZYME REGULATION
89.

"Location of binding sites in small molecule rescue of human carbonic anhydrase II."
Bhatt D. , Fisher S.Z. , Tu C. , McKenna R. , Silverman D.N.
Biophys. J.92:562-570(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH 4-METHYLIMIDAZOLE;MUTAGENESIS OF TRP-5 AND HIS-64
90.

"Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II."
Srivastava D.K. , Jude K.M. , Banerjee A.L. , Haldar M. , Manokaran S. , Kooren J. , Mallik S. , Christianson D.W.
J. Am. Chem. Soc.129:5528-5537(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.01 ANGSTROMS) IN COMPLEX WITH INHIBITORS
91.

"Inhibition of carbonic anhydrase II by thioxolone: a mechanistic and structural study."
Barrese A.A. III , Genis C. , Fisher S.Z. , Orwenyo J.N. , Kumara M.T. , Dutta S.K. , Phillips E. , Kiddle J.J. , Tu C. , Silverman D.N. , Govindasamy L. , Agbandje-McKenna M. , McKenna R. , Tripp B.C.
Biochemistry47:3174-3184(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) IN COMPLEX WITH INHIBITOR THIOXOLONE;ENZYME REGULATION
92.

"Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II."
Zheng J. , Avvaru B.S. , Tu C. , McKenna R. , Silverman D.N.
Biochemistry47:12028-12036(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF MUTANTS;MUTAGENESIS OF ASN-62;BIOPHYSICOCHEMICAL PROPERTIES
93.

"Carbonic anhydrase inhibitors. Interaction of 2-(hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies."
Guezel O. , Temperini C. , Innocenti A. , Scozzafava A. , Salman A. , Supuran C.T.
Bioorg. Med. Chem. Lett.18:152-158(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS) IN COMPLEX WITH INHIBITORS;ENZYME REGULATION
94.

"Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies."
Temperini C. , Cecchi A. , Boyle N.A. , Scozzafava A. , Cabeza J.E. , Wentworth P. Jr. , Blackburn G.M. , Supuran C.T.
Bioorg. Med. Chem. Lett.18:999-1005(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH INHIBITORS;ENZYME REGULATION
95.

"Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct."
Temperini C. , Cecchi A. , Scozzafava A. , Supuran C.T.
Bioorg. Med. Chem. Lett.18:2567-2573(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) IN COMPLEX WITH INHIBITORS;ENZYME REGULATION
96.

"Carbonic anhydrase inhibitors: the X-ray crystal structure of ethoxzolamide complexed to human isoform II reveals the importance of thr200 and gln92 for obtaining tight-binding inhibitors."
Di Fiore A. , Pedone C. , Antel J. , Waldeck H. , Witte A. , Wurl M. , Scozzafava A. , Supuran C.T. , De Simone G.
Bioorg. Med. Chem. Lett.18:2669-2674(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) IN COMPLEX WITH INHIBITORS
97.

"Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies."
Temperini C. , Innocenti A. , Scozzafava A. , Supuran C.T.
Bioorg. Med. Chem. Lett.18:4282-4286(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH INHIBITORS;ENZYME REGULATION
98.

"Carbonic anhydrase inhibitors: binding of indanesulfonamides to the human isoform II."
D'Ambrosio K. , Masereel B. , Thiry A. , Scozzafava A. , Supuran C.T. , De Simone G.
ChemMedChem3:473-477(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.40 ANGSTROMS) IN COMPLEX WITH INHIBITORS INDANESULFONAMIDES
99.

"Structure of a (129)Xe-cryptophane biosensor complexed with human carbonic anhydrase II."
Aaron J.A. , Chambers J.M. , Jude K.M. , Di Costanzo L. , Dmochowski I.J. , Christianson D.W.
J. Am. Chem. Soc.130:6942-6943(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH (129)XE-CRYPTOPHANE BIOSENSOR
100.

"Entrapment of carbon dioxide in the active site of carbonic anhydrase II."
Domsic J.F. , Avvaru B.S. , Kim C.U. , Gruner S.M. , Agbandje-McKenna M. , Silverman D.N. , McKenna R.
J. Biol. Chem.283:30766-30771(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.10 ANGSTROMS) IN COMPLEX WITH CO2
101.

"Structure-activity relationships of C-17 cyano-substituted estratrienes as anticancer agents."
Leese M.P. , Jourdan F.L. , Gaukroger K. , Mahon M.F. , Newman S.P. , Foster P.A. , Stengel C. , Regis-Lydi S. , Ferrandis E. , Di Fiore A. , De Simone G. , Supuran C.T. , Purohit A. , Reed M.J. , Potter B.V.
J. Med. Chem.51:1295-1308(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH INHIBITORS
102.

"Carbonic anhydrase inhibitors: bioreductive nitro-containing sulfonamides with selectivity for targeting the tumor associated isoforms IX and XII."
D'Ambrosio K. , Vitale R.-M. , Dogne J.-M. , Masereel B. , Innocenti A. , Scozzafava A. , De Simone G. , Supuran C.T.
J. Med. Chem.51:3230-3237(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) IN COMPLEX WITH INHIBITORS;ENZYME REGULATION
103.

"Anticancer steroid sulfatase inhibitors: synthesis of a potent fluorinated second-generation agent, in vitro and in vivo activities, molecular modeling, and protein crystallography."
Woo L.W.L. , Fischer D.S. , Sharland C.M. , Trusselle M. , Foster P.A. , Chander S.K. , Di Fiore A. , Supuran C.T. , De Simone G. , Purohit A. , Reed M.J. , Potter B.V.L.
Mol. Cancer Ther.7:2435-2444(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH INHIBITORS
104.

"Design of a carbonic anhydrase IX active-site mimic to screen inhibitors for possible anticancer properties."
Genis C. , Sippel K.H. , Case N. , Cao W. , Avvaru B.S. , Tartaglia L.J. , Govindasamy L. , Tu C. , Agbandje-McKenna M. , Silverman D.N. , Rosser C.J. , McKenna R.
Biochemistry48:1322-1331(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) IN COMPLEX WITH INHIBITORS;ENZYME REGULATION;MUTAGENESIS OF ALA-65 AND ASN-67
105.

"Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network."
Avvaru B.S. , Busby S.A. , Chalmers M.J. , Griffin P.R. , Venkatakrishnan B. , Agbandje-McKenna M. , Silverman D.N. , McKenna R.
Biochemistry48:7365-7372(2009) [PubMed] [Europe PMC] [Abstract]

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106.

"A thiabendazole sulfonamide shows potent inhibitory activity against mammalian and nematode alpha-carbonic anhydrases."
Crocetti L. , Maresca A. , Temperini C. , Hall R.A. , Scozzafava A. , Muehlschlegel F.A. , Supuran C.T.
Bioorg. Med. Chem. Lett.19:1371-1375(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.81 ANGSTROMS) OF 1-260 IN COMPLEX WITH INHIBITOR THIABENDAZOLE-5-SULFONAMIDE;ENZYME REGULATION
107.

"Non-zinc mediated inhibition of carbonic anhydrases: coumarins are a new class of suicide inhibitors."
Maresca A. , Temperini C. , Vu H. , Pham N.B. , Poulsen S.-A. , Scozzafava A. , Quinn R.J. , Supuran C.T.
J. Am. Chem. Soc.131:3057-3062(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-260 IN COMPLEX WITH COUMARIN INHIBITORS;ENZYME REGULATION
108.

"Carbonic anhydrase inhibitors. Comparison of chlorthalidone and indapamide X-ray crystal structures in adducts with isozyme II: when three water molecules and the keto-enol tautomerism make the difference."
Temperini C. , Cecchi A. , Scozzafava A. , Supuran C.T.
J. Med. Chem.52:322-328(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH INHIBITORS
109.

"Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors."
Vitale R.M. , Alterio V. , Innocenti A. , Winum J.-Y. , Monti S.M. , De Simone G. , Supuran C.T.
J. Med. Chem.52:5990-5998(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.41 ANGSTROMS) IN COMPLEX WITH INHIBITORS
110.

"S-glycosyl primary sulfonamides--a new structural class for selective inhibition of cancer-associated carbonic anhydrases."
Lopez M. , Paul B. , Hofmann A. , Morizzi J. , Wu Q.K. , Charman S.A. , Innocenti A. , Vullo D. , Supuran C.T. , Poulsen S.-A.
J. Med. Chem.52:6421-6432(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-260 IN COMPLEX WITH INHIBITORS
111.

"Dissecting the inhibition mechanism of cytosolic versus transmembrane carbonic anhydrases by ESR."
Ciani L. , Cecchi A. , Temperini C. , Supuran C.T. , Ristori S.
J. Phys. Chem. B113:13998-14005(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 1-260 IN COMPLEX WITH INHIBITORS;ENZYME REGULATION
112.

"Structural study of X-ray induced activation of carbonic anhydrase."
Sjoeblom B. , Polentarutti M. , Djinovic-Carugo K.
Proc. Natl. Acad. Sci. U.S.A.106:10609-10613(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.56 ANGSTROMS) IN COMPLEX WITH SUBSTRATES;ENZYME REGULATION
113.

"Chemical and enzymological characterization of an Indonesian variant of human erythrocyte carbonic anhydrase II, CAII Jogjakarta (17 Lys leads to Glu)."
Jones G.L. , Sofro A.S.M. , Shaw D.C.
Biochem. Genet.20:979-1000(1982) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT JOGJAKARTA GLU-18
114.

"A chemical and enzymological comparison of the common major human erythrocyte carbonic anhydrase II, its minor component, and a new genetic variant, CA II Melbourne (237 Pro leads to His)."
Jones G.L. , Shaw D.C.
Hum. Genet.63:392-399(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MELBOURNE HIS-236
115.

"Carbonic anhydrase II deficiency syndrome in a Belgian family is caused by a point mutation at an invariant histidine residue (107 His-->Tyr): complete structure of the normal human CA II gene."
Venta P.J. , Welty R.J. , Johnson T.M. , Sly W.S. , Tashian R.E.
Am. J. Hum. Genet.49:1082-1090(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OPTB3 TYR-107
116.

"Molecular basis of human carbonic anhydrase II deficiency."
Roth D.E. , Venta P.J. , Tashian R.E. , Sly W.S.
Proc. Natl. Acad. Sci. U.S.A.89:1804-1808(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OPTB3 TYR-107
117.

"A point mutation in exon 3 (His 107-->Tyr) in two unrelated Japanese patients with carbonic anhydrase II deficiency with central nervous system involvement."
Soda H. , Yukizane S. , Yoshida I. , Koga Y. , Aramaki S. , Kato H.
Hum. Genet.97:435-437(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OPTB3 TYR-107
118.

"Seven novel mutations in carbonic anhydrase II deficiency syndrome identified by SSCP and direct sequencing analysis."
Hu P.Y. , Lim E.J. , Ciccolella J. , Strisciuglio P. , Sly W.S.
Hum. Mutat.9:383-387(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT OPTB3 PRO-92
119.

"Carbonic anhydrase II deficiency syndrome (osteopetrosis with renal tubular acidosis and brain calcification): novel mutations in CA2 identified by direct sequencing expand the opportunity for genotype-phenotype correlation."
Shah G.N. , Bonapace G. , Hu P.Y. , Strisciuglio P. , Sly W.S.
Hum. Mutat.24:272-272(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS OPTB3 PRO-92; TYR-94; TYR-107 AND ARG-144;CHARACTERIZATION OF VARIANTS TYR-94 AND ARG-144

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