CALR ELISA Kit for Human(Homo sapiens) | EIAab.comCALR ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CALR(Gene name) > Human

CALR (Gene name),

Calreticulin (Protein name ), CALR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CALR(CRTC);

Protein name:

Calreticulin;

Alternative:

Calregulin;CRP55;HACBP;Endoplasmic reticulum resident protein 60(ERp60);grp60;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5. Interacts with PDIA3/ERp57 (By similarity). Interacts with NR3C1 and TRIM21. Interacts with GABARAP.

Function:

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export.

Subcellular Location:

Endoplasmic reticulum lumen Cytoplasm cytosol Secreted extracellular space extracellular matrix Cell surface Also found in cell surface (T cells), cytosol and extracellular matrix. Associated with the lytic granules in the cytolytic T-lymphocytes.

Protein Attributes:

Sequence length:

417

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

417:

KEEDEEEDVP | GQAKDEL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P27797

STRING:

9606.ENSP00000320866

KEGG:

hsa:811

UniGene:

Hs.515162

SMR:

P27797

MIM:

109091

Pfam:

PF00262

Uniprot:

P27797

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ELISA Kit for Human Calreticulin

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E1486r

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ELISA Kit for Human Calreticulin

Cat.:

E1486m

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96T

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ELISA Kit for Human Calreticulin

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E1486h

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ELISA Kit for Human Calreticulin

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E1486p

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ELISA Kit for Human Calreticulin

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ELISA Kit for Human Calreticulin

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ELISA Kit for Human Calreticulin

Cat.:

E1486b

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96T

CLIA Kit for Human Calreticulin

Cat.:

U1486b

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96T

CLIA Kit for Human Calreticulin

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CLIA Kit for Human Calreticulin

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U1486p

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96T

CLIA Kit for Human Calreticulin

Cat.:

U1486r

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96T

CLIA Kit for Human Calreticulin

Cat.:

U1486h

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96T

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CLIA Kit for Human Calreticulin

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CLIA Kit for Human Calreticulin

Cat.:

U1486m

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Polyclonal Antibody for Human Calreticulin

Cat.:

P1486Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Calreticulin

Cat.:

P1486Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Calreticulin

Cat.:

P1486Rb-h

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Polyclonal Antibody for Human Calreticulin

Monoclonal Antibody for Human Calreticulin

Protein for Human Calreticulin

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Molecular cloning, expression, and chromosome 19 localization of a human Ro/SS-A autoantigen."
McCauliffe D.P. , Lux F.A. , Lieu T.S. , Sanz I. , Hanke J. , Newkirk M.M. , Bachinski L.L. , Itoh Y. , Siciliano M.J. , Reichlin M. , Sontheimer R.D. , Capra J.D.
J. Clin. Invest.85:1379-1391(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Characterization of the autoantigen calreticulin."
Rokeach L.A. , Haselby J.A. , Meilof J.F. , Smeenk R.J. , Unnasch T.R. , Greene B.M. , Hoch S.O.
J. Immunol.147:3031-3039(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters."
McCauliffe D.P. , Yang Y.S. , Wilson J. , Sontheimer R.D. , Capra J.D.
J. Biol. Chem.267:2557-2562(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

Liu J. , Peng X. , Yuan J. , Qiang B.
Submitted (2001-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
8.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Eye.
tissue: Pancreas.
tissue: Skin.
11.

"Human placental calreticulin: purification, characterization and association with other proteins."
Houen G. , Koch C.
Acta Chem. Scand.48:905-911(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-48; 65-92; 96-114; 168-205 AND 257-354
tissue: Placenta.
12.

"Molecular characterization of human Ro/SS-A antigen. Amino terminal sequence of the protein moiety of human Ro/SS-A antigen and immunological activity of a corresponding synthetic peptide."
Lieu T.-S. , Newkirk M.M. , Capra J.D. , Sontheimer R.D.
J. Clin. Invest.82:96-101(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-41
13.

"In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits."
Rojiani M.V. , Finlay B.B. , Gray V. , Dedhar S.
Biochemistry30:9859-9866(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-36
14.

"Sequence similarity of calreticulin with a Ca2(+)-binding protein that co-purifies with an Ins(1,4,5)P3-sensitive Ca2+ store in HL-60 cells."
Krause K.-H. , Simmerman H.K.B. , Jones L.R. , Campbell K.P.
Biochem. J.270:545-548(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-32
15.

"Human liver protein map: a reference database established by microsequencing and gel comparison."
Hochstrasser D.F. , Frutiger S. , Paquet N. , Bairoch A. , Ravier F. , Pasquali C. , Sanchez J.-C. , Tissot J.-D. , Bjellqvist B. , Vargas R. , Appel R.D. , Hughes G.J.
Electrophoresis13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-28
tissue: Liver.
16.

Lubec G. , Afjehi-Sadat L. , Chen W.-Q. , Sun Y.
Submitted (2008-12) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-36; 74-111 AND 208-222;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
tissue: Fetal brain cortex.
17.

"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
Rasmussen H.H. , van Damme J. , Puype M. , Gesser B. , Celis J.E. , Vandekerckhove J.
Electrophoresis13:960-969(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 25-34; 56-62; 208-221 AND 273-278
tissue: Keratinocyte.
18.

"The calcium-binding protein calreticulin is a major constituent of lytic granules in cytolytic T lymphocytes."
Dupuis M. , Schaerer E. , Krause K.-H. , Tschopp J.
J. Exp. Med.177:1-7(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-27;SUBCELLULAR LOCATION
19.

"A two-dimensional gel database of human colon carcinoma proteins."
Ji H. , Reid G.E. , Moritz R.L. , Eddes J.S. , Burgess A.W. , Simpson R.J.
Electrophoresis18:605-613(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 18-26
tissue: Colon carcinoma.
20.

"Calreticulin functions as a molecular chaperone in the biosynthesis of myeloperoxidase."
Nauseef W.M. , McCormick S.J. , Clark R.A.
J. Biol. Chem.270:4741-4747(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
21.

"Calreticulin binds hYRNA and the 52-kDa polypeptide component of the Ro/SS-A ribonucleoprotein autoantigen."
Cheng S.T. , Nguyen T.Q. , Yang Y.S. , Capra J.D. , Sontheimer R.D.
J. Immunol.156:4484-4491(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TRIM21
22.

"Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules."
Arosa F.A. , de Jesus O. , Porto G. , Carmo A.M. , de Sousa M.
J. Biol. Chem.274:16917-16922(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
23.

"Calreticulin is a receptor for nuclear export."
Holaska J.M. , Black B.E. , Love D.C. , Hanover J.A. , Leszyk J. , Paschal B.M.
J. Cell Biol.152:127-140(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NR3C1;SUBCELLULAR LOCATION;MASS SPECTROMETRY
24.

"Human placental calreticulin characterization of domain structure and post-translational modifications."
Hoejrup P. , Roepstorff P. , Houen G.
Eur. J. Biochem.268:2558-2565(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;DISULFIDE BOND;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Placenta.
25.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-344
tissue: Liver.
26.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-48; LYS-159 AND LYS-209;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.

"Structural basis of cyclophilin B binding by the calnexin/calreticulin P-domain."
Kozlov G. , Bastos-Aristizabal S. , Maattanen P. , Rosenauer A. , Zheng F. , Killikelly A. , Trempe J.F. , Thomas D.Y. , Gehring K.
J. Biol. Chem.285:35551-35557(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PPIB
28.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
29.

"Structural framework of the GABARAP-calreticulin interface --implications for substrate binding to endoplasmic reticulum chaperones."
Thielmann Y. , Weiergraber O.H. , Mohrluder J. , Willbold D.
FEBS J.276:1140-1152(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 195-205 IN COMPLEX WITH GABARAP;INTERACTION WITH GABARAP
30.

"X-ray structure of the human calreticulin globular domain reveals a peptide-binding area and suggests a multi-molecular mechanism."
Chouquet A. , Paidassi H. , Ling W.L. , Frachet P. , Houen G. , Arlaud G.J. , Gaboriaud C.
PLoS ONE6:E17886-E17886(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 18-368 IN COMPLEX WITH CALCIUM IONS;DISULFIDE BOND

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