Protein name:
Azurocidin;
Alternative:
Heparin-binding protein(HBP);Cationic antimicrobial protein CAP37;
Organism:
Human (Homo sapiens).
General Annotation
Function:
This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.
Subcellular Location:
Cytoplasmic granule
Cytoplasmic granules of neutrophils.
Protein Attributes:
50:
MTRLTVLALL | AGLLASSRAG | SSPLLDIVGG | RKARPRQFPF | LASIQNQGRH |
100:
FCGGALIHAR | FVMTAASCFQ | SQNPGVSTVV | LGAYDLRRRE | RQSRQTFSIS |
150:
SMSENGYDPQ | QNLNDLMLLQ | LDREANLTSS | VTILPLPLQN | ATVEAGTRCQ |
200:
VAGWGSQRSG | GRLSRFPRFV | NVTVTPEDQC | RPNNVCTGVL | TRRGGICNGD |
250:
GGTPLVCEGL | AHGVASFSLG | PCGRGPDFFT | RVALFRDWID | GVLNNPGPGP |
Vaild Sequence:
Related Databases
Uniprot:
