Gene name:
CASP12 (UNQ9415/PRO34398) ;
Protein name:
Caspase-12 (CASP-12) ;
Alternative:
Organism:
CASP12 (Homo sapiens).
General Annotation
Function:
Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Protein Attributes:
50:
MADEKPSNGV | LVHMVKLLIK | TFLDGIFDDL | MENNVLNTDE | IHLIGKCLKF |
100:
VVSNAENLVD | DITETAQIAG | KIFREHLWNS | KKQLSSDISS | DGEREANMPG |
150:
LNIRNKEFNY | LHNRNGSELD | LLGMRDLLEN | LGYSVVIKEN | LTAQEMETAL |
200:
RQFAAHPEHQ | SSDSTFLVFM | SHSILNGICG | TKHWDQEPDV | LHDDTIFEIF |
250:
NNRNCQSLKD | KPKVIIMQAC | RGNGAGIVWF | TTDSGKASAD | THGRLLQGNI |
300:
CNDAVTKAHV | EKDFIAFKSS | TPHNVSWRHE | TNGSVFISQI | IYYFREYSWS |
341:
HHLEEIFQKV | QHSFETPNIL | TQLPTIERLS | MTRYFYLFPG | N
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human CASP-12
ELISA Kit for Human CASP-12
ELISA Kit for Human CASP-12
CLIA Kit for Human CASP-12
CLIA Kit for Human CASP-12
CLIA Kit for Human CASP-12
Polyclonal Antibody for Human CASP-12
Polyclonal Antibody for Human CASP-12
Polyclonal Antibody for Human CASP-12
Monoclonal Antibody for Human CASP-12
Monoclonal Antibody for Human CASP-12
Monoclonal Antibody for Human CASP-12
Protein for Human CASP-12
Protein for Human CASP-12
Protein for Human CASP-12
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);FUNCTION;POLYMORPHISM;TISSUE SPECIFICITY
tissue :
Lung .
2.
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F.
,
Gurney A.L.
,
Abaya E.
,
Baker K.
,
Baldwin D.T.
,
Brush J.
,
Chen J.
,
Chow B.
,
Chui C.
,
Crowley C.
,
Currell B.
,
Deuel B.
,
Dowd P.
,
Eaton D.
,
Foster J.S.
,
Grimaldi C.
,
Gu Q.
,
Hass P.E.
,
Heldens S.
,
Huang A.
,
Kim H.S.
,
Klimowski L.
,
Jin Y.
,
Johnson S.
,
Lee J.
,
Lewis L.
,
Liao D.
,
Mark M.R.
,
Robbie E.
,
Sanchez C.
,
Schoenfeld J.
,
Seshagiri S.
,
Simmons L.
,
Singh J.
,
Smith V.
,
Stinson J.
,
Vagts A.
,
Vandlen R.L.
,
Watanabe C.
,
Wieand D.
,
Woods K.
,
Xie M.-H.
,
Yansura D.G.
,
Yi S.
,
Yu G.
,
Yuan J.
,
Zhang M.
,
Zhang Z.
,
Goddard A.D.
,
Wood W.I.
,
Godowski P.J.
,
Gray A.M.
more...
Genome Res.13:2265-2270(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
3.
"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D.
,
Noguchi H.
,
Totoki Y.
,
Toyoda A.
,
Kuroki Y.
,
Dewar K.
,
Lloyd C.
,
Itoh T.
,
Takeda T.
,
Kim D.-W.
,
She X.
,
Barlow K.F.
,
Bloom T.
,
Bruford E.
,
Chang J.L.
,
Cuomo C.A.
,
Eichler E.
,
FitzGerald M.G.
,
Jaffe D.B.
,
LaButti K.
,
Nicol R.
,
Park H.-S.
,
Seaman C.
,
Sougnez C.
,
Yang X.
,
Zimmer A.R.
,
Zody M.C.
,
Birren B.W.
,
Nusbaum C.
,
Fujiyama A.
,
Hattori M.
,
Rogers J.
,
Lander E.S.
,
Sakaki Y.
more...
Nature440:497-500(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
"Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms."
Saleh M.
,
Vaillancourt J.P.
,
Graham R.K.
,
Huyck M.
,
Srinivasula S.M.
,
Alnemri E.S.
,
Steinberg M.H.
,
Nolan V.
,
Baldwin C.T.
,
Hotchkiss R.S.
,
Buchman T.G.
,
Zehnbauer B.A.
,
Hayden M.R.
,
Farrer L.A.
,
Roy S.
,
Nicholson D.W.
Nature429:75-79(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POLYMORPHISM;FUNCTION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POLYMORPHISM
6.
"Spread of an inactive form of caspase-12 in humans is due to recent positive selection."
Xue Y.
,
Daly A.
,
Yngvadottir B.
,
Liu M.
,
Coop G.
,
Kim Y.
,
Sabeti P.
,
Chen Y.
,
Stalker J.
,
Huckle E.
,
Burton J.
,
Leonard S.
,
Rogers J.
,
Tyler-Smith C.
Am. J. Hum. Genet.78:659-670(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : POLYMORPHISM