CTSD ELISA Kit for Human(Homo sapiens) | EIAab.comCTSD ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CTSD(Gene name) > Human

CTSD (Gene name),

Cathepsin D (Protein name ), CATD_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

CTSD(CPSD);

Protein name:

Cathepsin D;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Consists of a light chain and a heavy chain.

Function:

Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

Subcellular Location:

Lysosome Melanosome Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Protein Attributes:

Sequence length:

412

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

412:

NNRVGFAEAA | RL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

116840

String:

P07339

KEGG:

hsa:1509

Pfam:

PF07966

STRING:

9606.ENSP00000236671

UniGene:

Hs.654447

SMR:

P07339

Uniprot:

P07339

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ELISA Kit for Human Cathepsin D

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E1280h

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96T

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ELISA Kit for Human Cathepsin D

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E1280m

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96T

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ELISA Kit for Human Cathepsin D

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E1280c

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96T

ELISA Kit for Human Cathepsin D

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E1280p

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96T

ELISA Kit for Human Cathepsin D

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E1280b

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96T

ELISA Kit for Human Cathepsin D

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E1280d

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96T

ELISA Kit for Human Cathepsin D

Cat.:

E1280r

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96T

CLIA Kit for Human Cathepsin D

Cat.:

U1280r

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96T

CLIA Kit for Human Cathepsin D

Cat.:

U1280p

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96T

CLIA Kit for Human Cathepsin D

Cat.:

U1280m

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96T

CLIA Kit for Human Cathepsin D

Cat.:

U1280c

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96T

CLIA Kit for Human Cathepsin D

Cat.:

U1280d

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96T

CLIA Kit for Human Cathepsin D

Cat.:

U1280b

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96T

CLIA Kit for Human Cathepsin D

Cat.:

U1280h

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96T

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Polyclonal Antibody for Human Cathepsin D

Cat.:

P1280Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Cathepsin D

Cat.:

P1280Rb-m

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Polyclonal Antibody for Human Cathepsin D

Cat.:

P1280Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Cathepsin D

Monoclonal Antibody for Human Cathepsin D

Protein for Human Cathepsin D

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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Citations

[1].

"Serum betatrophin level increased in subjects with nonalcoholic fatty liver disease"

Zhu J, Li C, Dai Y, et al.

From:Int J Clin Exp Med

References

1.

"Cloning and sequence analysis of cDNA for human cathepsin D."
Faust P.L. , Kornfeld S. , Chirgwin J.M.
Proc. Natl. Acad. Sci. U.S.A.82:4910-4914(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Oestrogen regulates cathepsin D mRNA levels in oestrogen responsive human breast cancer cells."
Westley B.R. , May F.E.B.
Nucleic Acids Res.15:3773-3786(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Molecular organization of the human cathepsin D gene."
Redecker B. , Heckendorf B. , Grosch H.W. , Mersmann G. , Hasilik A.
DNA Cell Biol.10:423-431(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.
7.

"The human cathepsin D-encoding gene is transcribed from an estrogen-regulated and a constitutive start point."
May F.E. , Smith D.J. , Westley B.R.
Gene134:277-282(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
8.

"Characterization of the proximal estrogen-responsive element of human cathepsin D gene."
Augereau P. , Miralles F. , Cavailles V. , Gaudelet C. , Parker M. , Rochefort H.
Mol. Endocrinol.8:693-703(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-22
9.

Hochstrasser D.F. , Frutiger S. , Paquet N. , Bairoch A. , Ravier F. , Pasquali C. , Sanchez J.-C. , Tissot J.-D. , Bjellqvist B. , Vargas R. , Appel R.D. , Hughes G.J.
Submitted (1992-06) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 170-180
tissue: Liver.
10.

"Proteomic analysis of early melanosomes: identification of novel melanosomal proteins."
Basrur V. , Yang F. , Kushimoto T. , Higashimoto Y. , Yasumoto K. , Valencia J. , Muller J. , Vieira W.D. , Watabe H. , Shabanowitz J. , Hearing V.J. , Hunt D.F. , Appella E.
J. Proteome Res.2:69-79(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue: Melanoma.
11.

"Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-263
12.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-263
tissue: Plasma.
13.

"Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis."
Siintola E. , Partanen S. , Stromme P. , Haapanen A. , Haltia M. , Maehlen J. , Lehesjoki A.E. , Tyynela J.
Brain129:1438-1445(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CLN10;VARIANT ARG-282
14.

"Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes."
Chi A. , Valencia J.C. , Hu Z.-Z. , Watabe H. , Yamaguchi H. , Mangini N.J. , Huang H. , Canfield V.A. , Cheng K.C. , Yang F. , Abe R. , Yamagishi S. , Shabanowitz J. , Hearing V.J. , Wu C. , Appella E. , Hunt D.F.
J. Proteome Res.5:3135-3144(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
tissue: Melanoma.
15.

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-263
tissue: Platelet.
16.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-134 AND ASN-263
tissue: Liver.
17.

"Proteomics characterization of extracellular space components in the human aorta."
Didangelos A. , Yin X. , Mandal K. , Baumert M. , Jahangiri M. , Mayr M.
Mol. Cell. Proteomics9:2048-2062(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
18.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
Halim A. , Ruetschi U. , Larson G. , Nilsson J.
J. Proteome Res.12:573-584(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-63;IDENTIFICATION BY MASS SPECTROMETRY
20.

"Two crystal structures for cathepsin D: the lysosomal targeting signal and active site."
Metcalf P. , Fusek M.
EMBO J.12:1293-1302(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3 ANGSTROMS)
tissue: Spleen.
21.

"Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design."
Baldwin E.T. , Bhat T.N. , Gulnik S. , Hosur M.V. , Sowder R.C. II , Cachau R.E. , Collins J. , Silva A.M. , Erickson J.W.
Proc. Natl. Acad. Sci. U.S.A.90:6796-6800(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
tissue: Liver.
22.

"A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease."
Papassotiropoulos A. , Bagli M. , Kurz A. , Kornhuber J. , Forstl H. , Maier W. , Pauls J. , Lautenschlager N. , Heun R.
Ann. Neurol.47:399-403(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-58
23.

"Cathepsin D deficiency is associated with a human neurodegenerative disorder."
Steinfeld R. , Reinhardt K. , Schreiber K. , Hillebrand M. , Kraetzner R. , Bruck W. , Saftig P. , Gartner J.
Am. J. Hum. Genet.78:988-998(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CLN10 ILE-229 AND CYS-383
24.

"Update of the mutation spectrum and clinical correlations of over 360 mutations in eight genes that underlie the neuronal ceroid lipofuscinoses."
Kousi M. , Lehesjoki A.E. , Mole S.E.
Hum. Mutat.33:42-63(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CLN10 ILE-229

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