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Index > Protein center > CAV1(Gene name) > Human
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  • CAV1 (Gene name),
  • Caveolin-1 (Protein name ),  CAV1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    CAV1(CAV);
    Protein name:
    Caveolin-1;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP (By similarity). Interacts with BMX and BTK.
    Function:
    May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
    Subcellular Location:
    Golgi apparatus membrane Peripheral membrane protein Cell membrane Peripheral membrane protein Membrane caveola Peripheral membrane protein Membrane raft Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
    Protein Attributes:
    Sequence length:
    178
    Sequence:
    50:
    MSGGKYVDSE | GHLYTVPIRE | QGNIYKPNNK | AMADELSEKQ | VYDAHTKEID | 
    100:
    LVNRDPKHLN | DDVVKIDFED | VIAEPEGTHS | FDGIWKASFT | TFTVTKYWFY | 
    150:
    RLLSALFGIP | MALIWGIYFA | ILSFLHIWAV | VPCIKSFLIE | IQCISRVYSI | 
    178:
    YVHTVCDPLF | EAVGKIFSNV | RINLQKEI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    Pfam:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Caveolin-1
    Cat.:
    E0214h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Caveolin-1
    Cat.:
    E0214r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Caveolin-1
    Cat.:
    E0214b
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Caveolin-1
    Cat.:
    E0214m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Caveolin-1
    Cat.:
    E0214p
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Caveolin-1
    MSDS:
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    ELISA Kit for Human Caveolin-1
    Cat.:
    E0214c
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Caveolin-1
    Cat.:
    E0214d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Caveolin-1
    Cat.:
    U0214c
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Caveolin-1
    Cat.:
    U0214h
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Caveolin-1
    Cat.:
    U0214r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Caveolin-1
    Cat.:
    U0214p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Caveolin-1
    Cat.:
    U0214d
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Caveolin-1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Caveolin-1
    Cat.:
    U0214b
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Caveolin-1
    Cat.:
    U0214m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Caveolin-1
    Cat.:
    P0214Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Caveolin-1
    Polyclonal Antibody for Human Caveolin-1
    Cat.:
    P0214Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Caveolin-1
    Polyclonal Antibody for Human Caveolin-1
    Polyclonal Antibody for Human Caveolin-1
    Cat.:
    P0214Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Caveolin-1
    Polyclonal Antibody for Human Caveolin-1
    Monoclonal Antibody for Human Caveolin-1
    Monoclonal Antibody for Human Caveolin-1
    Monoclonal Antibody for Human Caveolin-1
    Monoclonal Antibody for Human Caveolin-1
    Monoclonal Antibody for Human Caveolin-1
    Monoclonal Antibody for Human Caveolin-1
    Monoclonal Antibody for Human Caveolin-1
    Monoclonal Antibody for Human Caveolin-1
    Protein for Human Caveolin-1
    Protein for Human Caveolin-1
    Protein for Human Caveolin-1
    Protein for Human Caveolin-1
    Protein for Human Caveolin-1
    Protein for Human Caveolin-1
    Protein for Human Caveolin-1
    Protein for Human Caveolin-1

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    Precision
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    Linearity
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    References
    1. 1.
      "Caveolin-1 mutations (P132L and null) and the pathogenesis of breast cancer: caveolin-1 (P132L) behaves in a dominant-negative manner and caveolin-1 (-/-) null mice show mammary epithelial cell hyperplasia."
      Lee H. , Park D.S. , Razani B. , Russell R.G. , Pestell R.G. , Lisanti M.P.
      Am. J. Pathol.161:1357-1369(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-132
    2. 2.
      "The sequence of human caveolin reveals identity with VIP21, a component of transport vesicles."
      Glenney J.R. Jr.
      FEBS Lett.314:45-48(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Lung.
    3. 3.
      "Analysis of the CAVEOLIN-1 gene at human chromosome 7q31.1 in primary tumours and tumour-derived cell lines."
      Hurlstone A.F. , Reid G. , Reeves J.R. , Fraser J. , Strathdee G. , Rahilly M. , Parkinson E.K. , Black D.M.
      Oncogene18:1881-1890(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Sequence and detailed organization of the human caveolin-1 and -2 genes located near the D7S522 locus (7q31.1). Methylation of a CpG island in the 5' promoter region of the caveolin-1 gene in human breast cancer cell lines."
      Engelman J.A. , Zhang X.L. , Lisanti M.P.
      FEBS Lett.448:221-230(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Lung.
    7. 7.
      "N-terminal processing and modifications of caveolin-1 in caveolae from human adipocytes."
      Vainonen J.P. , Aboulaich N. , Turkina M.V. , Stralfors P. , Vener A.V.
      Biochem. Biophys. Res. Commun.320:480-486(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-66;SUBCELLULAR LOCATION;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;PHOSPHORYLATION AT SER-37;CLEAVAGE OF INITIATOR METHIONINE (ISOFORM 2);ACETYLATION AT ALA-2 (ISOFORM 2);PHOSPHORYLATION AT SER-6 (ISOFORM 2)
      tissue: Adipose tissue.
    8. 8.
      "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
      Aboulaich N. , Vainonen J.P. , Stralfors P. , Vener A.V.
      Biochem. J.383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 58-65
      tissue: Adipocyte.
    9. 9.
      "Phosphorylation of caveolin by src tyrosine kinases. The alpha-isoform of caveolin is selectively phosphorylated by v-Src in vivo."
      Li S. , Seitz R. , Lisanti M.P.
      J. Biol. Chem.271:3863-3868(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-6; TYR-14 AND TYR-25
    10. 10.
      "Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx."
      Vargas L. , Nore B.F. , Berglof A. , Heinonen J.E. , Mattsson P.T. , Smith C.I. , Mohamed A.J.
      J. Biol. Chem.277:9351-9357(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BMX AND BTK
    11. 11.
      "Identification and characterization of a novel human plant pathogenesis-related protein that localizes to lipid-enriched microdomains in the Golgi complex."
      Eberle H.B. , Serrano R.L. , Fuellekrug J. , Schlosser A. , Lehmann W.D. , Lottspeich F. , Kaloyanova D. , Wieland F.T. , Helms J.B.
      J. Cell Sci.115:827-838(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GLIPR2
      tissue: Brain.
    12. 12.
      "c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14."
      Sanguinetti A.R. , Mastick C.C.
      Cell. Signal.15:289-298(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-14
    13. 13.
      "Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN."
      Schilling K. , Opitz N. , Wiesenthal A. , Oess S. , Tikkanen R. , Mueller-Esterl W. , Icking A.
      Mol. Biol. Cell17:3870-3880(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NOSTRIN
    14. 14.
      "The rotavirus enterotoxin NSP4 directly interacts with the caveolar structural protein caveolin-1."
      Parr R.D. , Storey S.M. , Mitchell D.M. , McIntosh A.L. , Zhou M. , Mir K.D. , Ball J.M.
      J. Virol.80:2842-2854(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ROTAVIRUS A NSP4
    15. 15.
      "Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1."
      Ohnuma K. , Uchiyama M. , Yamochi T. , Nishibashi K. , Hosono O. , Takahashi N. , Kina S. , Tanaka H. , Lin X. , Dang N.H. , Morimoto C.
      J. Biol. Chem.282:10117-10131(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DPP4;SUBCELLULAR LOCATION
    16. 16.
      "Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy."
      Kim C.A. , Delepine M. , Boutet E. , El Mourabit H. , Le Lay S. , Meier M. , Nemani M. , Bridel E. , Leite C.C. , Bertola D.R. , Semple R.K. , O'Rahilly S. , Dugail I. , Capeau J. , Lathrop M. , Magre J.
      J. Clin. Endocrinol. Metab.93:1129-1134(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CGL3
    17. 17.
      "Heterozygous CAV1 frameshift mutations (MIM 601047) in patients with atypical partial lipodystrophy and hypertriglyceridemia."
      Cao H. , Alston L. , Ruschman J. , Hegele R.A.
      Lipids Health Dis.7:3-3(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN LCCNS
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    20. 20.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND LYS-5;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    21. 21.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    24. 24.
      "Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension."
      Austin E.D. , Ma L. , LeDuc C. , Berman Rosenzweig E. , Borczuk A. , Phillips J.A. III , Palomero T. , Sumazin P. , Kim H.R. , Talati M.H. , West J. , Loyd J.E. , Chung W.K.
      Circ. Cardiovasc. Genet.5:336-343(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN PPH3
    25. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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