Protein name:
Caveolin-1 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N-terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP (By similarity). Interacts with BMX and BTK.
Function:
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway.
Subcellular Location:
Golgi apparatus membrane
Peripheral membrane protein
Cell membrane
Peripheral membrane protein
Membrane
caveola
Peripheral membrane protein
Membrane raft
Colocalized with DPP4 in membrane rafts. Potential hairpin-like structure in the membrane. Membrane protein of caveolae.
Protein Attributes:
50:
MSGGKYVDSE | GHLYTVPIRE | QGNIYKPNNK | AMADELSEKQ | VYDAHTKEID |
100:
LVNRDPKHLN | DDVVKIDFED | VIAEPEGTHS | FDGIWKASFT | TFTVTKYWFY |
150:
RLLSALFGIP | MALIWGIYFA | ILSFLHIWAV | VPCIKSFLIE | IQCISRVYSI |
178:
YVHTVCDPLF | EAVGKIFSNV | RINLQKEI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Bovine
Mouse
Pig
Chicken
Rabbit
Dog
ELISA Kit for Human Caveolin-1
ELISA Kit for Human Caveolin-1
ELISA Kit for Human Caveolin-1
ELISA Kit for Human Caveolin-1
ELISA Kit for Human Caveolin-1
ELISA Kit for Human Caveolin-1
ELISA Kit for Human Caveolin-1
ELISA Kit for Human Caveolin-1
CLIA Kit for Human Caveolin-1
CLIA Kit for Human Caveolin-1
CLIA Kit for Human Caveolin-1
CLIA Kit for Human Caveolin-1
CLIA Kit for Human Caveolin-1
CLIA Kit for Human Caveolin-1
CLIA Kit for Human Caveolin-1
CLIA Kit for Human Caveolin-1
Polyclonal Antibody for Human Caveolin-1
Polyclonal Antibody for Human Caveolin-1
Polyclonal Antibody for Human Caveolin-1
Polyclonal Antibody for Human Caveolin-1
Polyclonal Antibody for Human Caveolin-1
Polyclonal Antibody for Human Caveolin-1
Polyclonal Antibody for Human Caveolin-1
Polyclonal Antibody for Human Caveolin-1
Monoclonal Antibody for Human Caveolin-1
Monoclonal Antibody for Human Caveolin-1
Monoclonal Antibody for Human Caveolin-1
Monoclonal Antibody for Human Caveolin-1
Monoclonal Antibody for Human Caveolin-1
Monoclonal Antibody for Human Caveolin-1
Monoclonal Antibody for Human Caveolin-1
Monoclonal Antibody for Human Caveolin-1
Protein for Human Caveolin-1
Protein for Human Caveolin-1
Protein for Human Caveolin-1
Protein for Human Caveolin-1
Protein for Human Caveolin-1
Protein for Human Caveolin-1
Protein for Human Caveolin-1
Protein for Human Caveolin-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
B Yang, N Wang, SQ Wang, et al.
[2].
Bang O Y, Chung J W, Kim S J, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT LEU-132
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Lung .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N.
,
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,
Rolfs A.
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Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
tissue :
Lung .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-66;SUBCELLULAR LOCATION;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2;PHOSPHORYLATION AT SER-37;CLEAVAGE OF INITIATOR METHIONINE (ISOFORM 2);ACETYLATION AT ALA-2 (ISOFORM 2);PHOSPHORYLATION AT SER-6 (ISOFORM 2)
tissue :
Adipose tissue .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 58-65
tissue :
Adipocyte .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-6; TYR-14 AND TYR-25
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BMX AND BTK
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GLIPR2
tissue :
Brain .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT TYR-14
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NOSTRIN
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ROTAVIRUS A NSP4
15.
"Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1."
Ohnuma K.
,
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,
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,
Hosono O.
,
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,
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J. Biol. Chem.282:10117-10131(2007)
[
PubMed ]
[
Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH DPP4;SUBCELLULAR LOCATION
16.
"Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy."
Kim C.A.
,
Delepine M.
,
Boutet E.
,
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,
Le Lay S.
,
Meier M.
,
Nemani M.
,
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J. Clin. Endocrinol. Metab.93:1129-1134(2008)
[
PubMed ]
[
Europe PMC ]
[
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN CGL3
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN LCCNS
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2 AND LYS-5;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
21.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
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,
Jensen L.J.
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Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-37;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.
"Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension."
Austin E.D.
,
Ma L.
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LeDuc C.
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Phillips J.A. III
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Circ. Cardiovasc. Genet.5:336-343(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN PPH3
25.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
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,
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Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]