Protein name:
G1/S-specific cyclin-D2 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with either CDK4 or CDK6 protein kinase to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity.
Function:
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
Subcellular Location:
Nucleus
Cytoplasm
Membrane
Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Protein Attributes:
50:
MELLCHEVDP | VRRAVRDRNL | LRDDRVLQNL | LTIEERYLPQ | CSYFKCVQKD |
100:
IQPYMRRMVA | TWMLEVCEEQ | KCEEEVFPLA | MNYLDRFLAG | VPTPKSHLQL |
150:
LGAVCMFLAS | KLKETSPLTA | EKLCIYTDNS | IKPQELLEWE | LVVLGKLKWN |
200:
LAAVTPHDFI | EHILRKLPQQ | REKLSLIRKH | AQTFIALCAT | DFKFAMYPPS |
250:
MIATGSVGAA | ICGLQQDEEV | SSLTCDALTE | LLAKITNTDV | DCLKACQEQI |
289:
EAVLLNSLQQ | YRQDQRDGSK | SEDELDQAST | PTDVRDIDL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Pig
Bovine
Chicken
Rat
ELISA Kit for Human G1/S-specific cyclin-D2
ELISA Kit for Human G1/S-specific cyclin-D2
ELISA Kit for Human G1/S-specific cyclin-D2
ELISA Kit for Human G1/S-specific cyclin-D2
ELISA Kit for Human G1/S-specific cyclin-D2
ELISA Kit for Human G1/S-specific cyclin-D2
CLIA Kit for Human G1/S-specific cyclin-D2
CLIA Kit for Human G1/S-specific cyclin-D2
CLIA Kit for Human G1/S-specific cyclin-D2
CLIA Kit for Human G1/S-specific cyclin-D2
CLIA Kit for Human G1/S-specific cyclin-D2
CLIA Kit for Human G1/S-specific cyclin-D2
Polyclonal Antibody for Human G1/S-specific cyclin-D2
Polyclonal Antibody for Human G1/S-specific cyclin-D2
Polyclonal Antibody for Human G1/S-specific cyclin-D2
Polyclonal Antibody for Human G1/S-specific cyclin-D2
Polyclonal Antibody for Human G1/S-specific cyclin-D2
Polyclonal Antibody for Human G1/S-specific cyclin-D2
Monoclonal Antibody for Human G1/S-specific cyclin-D2
Monoclonal Antibody for Human G1/S-specific cyclin-D2
Monoclonal Antibody for Human G1/S-specific cyclin-D2
Monoclonal Antibody for Human G1/S-specific cyclin-D2
Monoclonal Antibody for Human G1/S-specific cyclin-D2
Monoclonal Antibody for Human G1/S-specific cyclin-D2
Protein for Human G1/S-specific cyclin-D2
Protein for Human G1/S-specific cyclin-D2
Protein for Human G1/S-specific cyclin-D2
Protein for Human G1/S-specific cyclin-D2
Protein for Human G1/S-specific cyclin-D2
Protein for Human G1/S-specific cyclin-D2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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[
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[
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[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Bone marrow .
tissue :
Uterus .
10.
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Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-240
tissue :
Placenta .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 105-140 (ISOFORM 2)
tissue :
Glioblastoma .
12.
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Cited for : INTERACTION WITH CDK4;SUBCELLULAR LOCATION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION (ISOFORM 2);ALTERNATIVE SPLICING
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : UBIQUITINATION BY SCF(FBXL2)