Ccnd3 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comCcnd3 ELISA Kit for Rat(Rattus norvegicus)

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Ccnd3 (Gene name),

G1/S-specific cyclin-D3 (Protein name ), CCND3_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Ccnd3;

Protein name:

G1/S-specific cyclin-D3;

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Component of the ternary complex cyclin D/CDK4/CDKN1B required for nuclear translocation and modulation of CDK4-mediated kinase activity. Can form similar complexes with either CDKN1A or CDKN2A. Interacts with ATF5 and EIF3K.

Function:

Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.

Subcellular Location:

Nucleus Cytoplasm Membrane Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members.

Protein Attributes:

Sequence length:

293

Sequence:

50:

100:

150:

200:

250:

293:

ALRESLREAA | QTAPSPVPKA | PGGSSSQGPS | QTSTPTDVTA | IHL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:25193

UniGene:

Rn.3483

Pfam:

PF02984

Uniprot:

P48961

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ELISA Kit for Rat G1/S-specific cyclin-D3

Cat.:

E0587h

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96T

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ELISA Kit for Rat G1/S-specific cyclin-D3

Cat.:

E0587m

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96T

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ELISA Kit for Rat G1/S-specific cyclin-D3

Cat.:

E0587b

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96T

ELISA Kit for Rat G1/S-specific cyclin-D3

Cat.:

E0587r

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96T

CLIA Kit for Rat G1/S-specific cyclin-D3

Cat.:

U0587b

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Packing:

96T

CLIA Kit for Rat G1/S-specific cyclin-D3

Cat.:

U0587h

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat G1/S-specific cyclin-D3

Cat.:

U0587m

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat G1/S-specific cyclin-D3

Cat.:

U0587r

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96T

Polyclonal Antibody for Rat G1/S-specific cyclin-D3

Cat.:

P0587Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat G1/S-specific cyclin-D3

Cat.:

P0587Rb-r

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40ug/0.2ml

Polyclonal Antibody for Rat G1/S-specific cyclin-D3

Cat.:

P0587Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat G1/S-specific cyclin-D3

Protein for Rat G1/S-specific cyclin-D3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Induction of D2 and D3 cyclin-encoding genes during promotion of the G1/S transition by prolactin in rat Nb2 cells."
Hosokawa Y. , Onga T. , Nakashima K.
Gene147:249-252(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Structure and characterization of rat cyclin D3 promoter."
Yang M. , Hosokawa Y. , Kaneko S. , Tanaka M. , Nakashima K.
Gene181:153-159(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-66
strain: Sprague-Dawley.
tissue: Liver.

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