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Index > Protein center > CD109(Gene name) > Human
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  • CD109 (Gene name),
  • CD109 antigen (Protein name ),  CD109_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CD109(CPAMD7);
    Protein name:
    CD109 antigen;
    Alternative:
    C3 and PZP-like alpha-2-macroglobulin domain-containing protein 7;150 kDa TGF-beta-1-binding protein;p180;Platelet-specific Gov antigen;r150;
    CD:
    CD109;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer; disulfide-linked. Interacts with TGFB1 and TGFBR1. Forms a heteromeric complex with TGFBR1, TGFBR2 and TGFBR3 in a ligand-independent manner.
    Function:
    Modulates negatively TGFB1 signaling in keratinocytes.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor
    Protein Attributes:
    Sequence length:
    1445
    Sequence:
    50:
    MQGPPLLTAA | HLLCVCTAAL | AVAPGPRFLV | TAPGIIRPGG | NVTIGVELLE | 
    100:
    HCPSQVTVKA | ELLKTASNLT | VSVLEAEGVF | EKGSFKTLTL | PSLPLNSADE | 
    150:
    IYELRVTGRT | QDEILFSNST | RLSFETKRIS | VFIQTDKALY | KPKQEVKFRI | 
    200:
    VTLFSDFKPY | KTSLNILIKD | PKSNLIQQWL | SQQSDLGVIS | KTFQLSSHPI | 
    250:
    LGDWSIQVQV | NDQTYYQSFQ | VSEYVLPKFE | VTLQTPLYCS | MNSKHLNGTI | 
    300:
    TAKYTYGKPV | KGDVTLTFLP | LSFWGKKKNI | TKTFKINGSA | NFSFNDEEMK | 
    350:
    NVMDSSNGLS | EYLDLSSPGP | VEILTTVTES | VTGISRNVST | NVFFKQHDYI | 
    400:
    IEFFDYTTVL | KPSLNFTATV | KVTRADGNQL | TLEERRNNVV | ITVTQRNYTE | 
    450:
    YWSGSNSGNQ | KMEAVQKINY | TVPQSGTFKI | EFPILEDSSE | LQLKAYFLGS | 
    500:
    KSSMAVHSLF | KSPSKTYIQL | KTRDENIKVG | SPFELVVSGN | KRLKELSYMV | 
    550:
    VSRGQLVAVG | KQNSTMFSLT | PENSWTPKAC | VIVYYIEDDG | EIISDVLKIP | 
    600:
    VQLVFKNKIK | LYWSKVKAEP | SEKVSLRISV | TQPDSIVGIV | AVDKSVNLMN | 
    650:
    ASNDITMENV | VHELELYNTG | YYLGMFMNSF | AVFQECGLWV | LTDANLTKDY | 
    700:
    IDGVYDNAEY | AERFMEENEG | HIVDIHDFSL | GSSPHVRKHF | PETWIWLDTN | 
    750:
    MGYRIYQEFE | VTVPDSITSW | VATGFVISED | LGLGLTTTPV | ELQAFQPFFI | 
    800:
    FLNLPYSVIR | GEEFALEITI | FNYLKDATEV | KVIIEKSDKF | DILMTSNEIN | 
    850:
    ATGHQQTLLV | PSEDGATVLF | PIRPTHLGEI | PITVTALSPT | ASDAVTQMIL | 
    900:
    VKAEGIEKSY | SQSILLDLTD | NRLQSTLKTL | SFSFPPNTVT | GSERVQITAI | 
    950:
    GDVLGPSING | LASLIRMPYG | CGEQNMINFA | PNIYILDYLT | KKKQLTDNLK | 
    1000:
    EKALSFMRQG | YQRELLYQRE | DGSFSAFGNY | DPSGSTWLSA | FVLRCFLEAD | 
    1050:
    PYIDIDQNVL | HRTYTWLKGH | QKSNGEFWDP | GRVIHSELQG | GNKSPVTLTA | 
    1100:
    YIVTSLLGYR | KYQPNIDVQE | SIHFLESEFS | RGISDNYTLA | LITYALSSVG | 
    1150:
    SPKAKEALNM | LTWRAEQEGG | MQFWVSSESK | LSDSWQPRSL | DIEVAAYALL | 
    1200:
    SHFLQFQTSE | GIPIMRWLSR | QRNSLGGFAS | TQDTTVALKA | LSEFAALMNT | 
    1250:
    ERTNIQVTVT | GPSSPSPVKF | LIDTHNRLLL | QTAELAVVQP | TAVNISANGF | 
    1300:
    GFAICQLNVV | YNVKASGSSR | RRRSIQNQEA | FDLDVAVKEN | KDDLNHVDLN | 
    1350:
    VCTSFSGPGR | SGMALMEVNL | LSGFMVPSEA | ISLSETVKKV | EYDHGKLNLY | 
    1400:
    LDSVNETQFC | VNIPAVRNFK | VSNTQDASVS | IVDYYEPRRQ | AVRSYNSEVK | 
    1445:
    LSSCDLCSDV | QGCRPCEDGA | SGSHHHSSVI | FIFCFKLLYF | MELWL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    MIM:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
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    Polyclonal Antibody for Human CD109 antigen
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    Packing:
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    Monoclonal Antibody for Human CD109 antigen
    Monoclonal Antibody for Human CD109 antigen
    Protein for Human CD109 antigen
    Protein for Human CD109 antigen

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins."
      Lin M. , Sutherland D.R. , Horsfall W. , Totty N. , Yeo E. , Nayar R. , Wu X.-F. , Schuh A.C.
      Blood99:1683-1691(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 86-98; 127-137; 170-183; 185-196; 355-374; 413-425; 444-451; 465-471; 478-491; 494-510; 573-589; 649-655; 666-672; 677-683; 698-709 AND 791-806;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;VARIANT MET-1241
    2. 2.
      "CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family."
      Solomon K.R. , Sharma P. , Chan M. , Morrison P.T. , Finberg R.W.
      Gene327:171-183(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 22-50 (ISOFORM 1);TISSUE SPECIFICITY;VARIANTS SER-703; SER-797 AND ILE-845
    3. 3.
      "Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes."
      Finnson K.W. , Tam B.Y.Y. , Liu K. , Marcoux A. , Lepage P. , Roy S. , Bizet A.A. , Philip A.
      FASEB J.20:1525-1527(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);PROTEIN SEQUENCE OF 173-191;FUNCTION;INTERACTION WITH TGFB1 AND TGFBR1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PROTEOLYTIC CLEAVAGE;VARIANTS SER-703; SER-797 AND ILE-845
      tissue: Placenta.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3);VARIANTS SER-703; SER-797 AND ILE-845
      tissue: Chondrocyte.
      tissue: Trachea.
      tissue: Vascular endothelial cell.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANTS SER-703; SER-797; ILE-845 AND MET-1241
      tissue: Colon endothelium.
    6. 6.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "CD109 defines an ancient branch of the alpha2M/C3, C4, C5 family."
      Prosper J.Y.A. , Wu X.-F. , Sutherland D.R. , Irwin D.M. , Schuh A.C.
      Submitted (2004-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 370-444 AND 922-959
    8. 8.
      "A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens."
      Schuh A.C. , Watkins N.A. , Nguyen Q. , Harmer N.J. , Lin M. , Prosper J.Y.A. , Campbell K. , Sutherland D.R. , Metcalfe P. , Horsfall W. , Ouwehand W.H.
      Blood99:1692-1698(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 703-741;VARIANT GOV(B) SER-703
    9. 9.
      "Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets."
      Sutherland D.R. , Yeo E. , Ryan A. , Mills G.B. , Bailey D. , Baker M.A.
      Blood77:84-93(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC CLEAVAGE;GLYCOSYLATION
    10. 10.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-68; ASN-118; ASN-247 AND ASN-419
      tissue: Plasma.
    11. 11.
      "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
      Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
      Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-247
      tissue: Platelet.
    12. 12.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-419
      tissue: Liver.
    13. 13.
      "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B. , Bausch-Fluck D. , Henderson C. , O'Brien R. , Bibel M. , Schiess R. , Aebersold R. , Watts J.D.
      Nat. Biotechnol.27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-68 AND ASN-118
      tissue: Leukemic T-cell.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-1007 AND LYS-1065
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