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Index > Protein center > CD19(Gene name) > Human
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  • CD19 (Gene name),
  • B-lymphocyte antigen CD19 (Protein name ),  CD19_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CD19;
    Protein name:
    B-lymphocyte antigen CD19;
    Alternative:
    Differentiation antigen CD19;B-lymphocyte surface antigen B4;T-cell surface antigen Leu-12;
    CD:
    CD19;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a complex with CD21, CD81 and CD225 in the membrane of mature B cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409.
    Function:
    Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    556
    Sequence:
    50:
    MPPPRLLFFL | LFLTPMEVRP | EEPLVVKVEE | GDNAVLQCLK | GTSDGPTQQL | 
    100:
    TWSRESPLKP | FLKLSLGLPG | LGIHMRPLAI | WLFIFNVSQQ | MGGFYLCQPG | 
    150:
    PPSEKAWQPG | WTVNVEGSGE | LFRWNVSDLG | GLGCGLKNRS | SEGPSSPSGK | 
    200:
    LMSPKLYVWA | KDRPEIWEGE | PPCLPPRDSL | NQSLSQDLTM | APGSTLWLSC | 
    250:
    GVPPDSVSRG | PLSWTHVHPK | GPKSLLSLEL | KDDRPARDMW | VMETGLLLPR | 
    300:
    ATAQDAGKYY | CHRGNLTMSF | HLEITARPVL | WHWLLRTGGW | KVSAVTLAYL | 
    350:
    IFCLCSLVGI | LHLQRALVLR | RKRKRMTDPT | RRFFKVTPPP | GSGPQNQYGN | 
    400:
    VLSLPTPTSG | LGRAQRWAAG | LGGTAPSYGN | PSSDVQADGA | LGSRSPPGVG | 
    450:
    PEEEEGEGYE | EPDSEEDSEF | YENDSNLGQD | QLSQDGSGYE | NPEDEPLGPE | 
    500:
    DEDSFSNAES | YENEDEELTQ | PVARTMDFLS | PHGSAWDPSR | EATSLGSQSY | 
    550:
    EDMRGILYAA | PQLRSIRGQP | GPNHEEDADS | YENMDNPDGP | DPAWGGGGRM | 
    556:
    GTWSTR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    MIM:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human B-lymphocyte antigen CD19
    Cat.:
    E1873h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human B-lymphocyte antigen CD19
    Cat.:
    E1873m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human B-lymphocyte antigen CD19
    Cat.:
    U1873h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human B-lymphocyte antigen CD19
    Cat.:
    U1873m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human B-lymphocyte antigen CD19
    Cat.:
    P1873Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human B-lymphocyte antigen CD19
    Cat.:
    P1873Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human B-lymphocyte antigen CD19
    Monoclonal Antibody for Human B-lymphocyte antigen CD19
    Protein for Human B-lymphocyte antigen CD19
    Protein for Human B-lymphocyte antigen CD19
    Cat.:
    R1873h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail."
      Stamenkovic I. , Seed B.
      J. Exp. Med.168:1205-1210(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS VAL-174 AND HIS-514
    2. 2.
      "Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily."
      Tedder T.F. , Isaacs C.M.
      J. Immunol.143:712-717(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS VAL-174 AND HIS-514
      tissue: Tonsil.
    3. 3.
      "The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP."
      Kozmik Z. , Wang S. , Doerfler P. , Adams B. , Busslinger M.
      Mol. Cell. Biol.12:2662-2672(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VAL-174
    4. 4.
      "Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes."
      Zhou L.J. , Ord D.C. , Omori S.A. , Tedder T.F.
      Immunogenetics35:102-111(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VAL-174
      tissue: Blood.
    5. 5.
      "Polymorphisms of human CD19 gene: possible association with susceptibility to systemic lupus erythematosus in Japanese."
      Kuroki K. , Tsuchiya N. , Tsao B.P. , Grossman J.M. , Fukazawa T. , Hagiwara K. , Kano H. , Takazoe M. , Iwata T. , Hashimoto H. , Tokunaga K.
      Genes Immun.3:S21-S30(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VAL-174
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT VAL-174
      tissue: Spleen.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VAL-174
    8. 8.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT VAL-174
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: B-cell.
    11. 11.
      "CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells."
      Roifman C.M. , Ke S.
      Biochem. Biophys. Res. Commun.194:222-225(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH LYN
    12. 12.
      "Tyrosine phosphorylation of CD19 in pre-B and mature B cells."
      Chalupny N.J. , Kanner S.B. , Schieven G.L. , Wee S. , Gilliland L.K. , Aruffo A. , Ledbetter J.A.
      EMBO J.12:2691-2696(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION
    13. 13.
      "Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines."
      Brooks S.R. , Li X. , Volanakis E.J. , Carter R.H.
      J. Immunol.164:3123-3131(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRB2; SOS; VAV AND PLCG2;PHOSPHORYLATION AT TYR-348; TYR-378; TYR-409 AND TYR-439
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CVID3
    15. 15.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
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