CD22 ELISA Kit for Human(Homo sapiens) | EIAab.comCD22 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CD22(Gene name) > Human

CD22 (Gene name),

B-cell receptor CD22 (Protein name ), CD22_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CD22(SIGLEC2);

Protein name:

B-cell receptor CD22;

Alternative:

Sialic acid-binding Ig-like lectin 2(Siglec-2);B-lymphocyte cell adhesion molecule(BL-CAM);T-cell surface antigen Leu-14;

CD:

CD22;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Predominantly monomer of isoform CD22-beta. Also found as heterodimer of isoform CD22-beta and a shorter isoform. Interacts with PTPN6/SHP-1, LYN, SYK, PIK3R1/PIK3R2 and PLCG1 upon phosphorylation. Interacts with GRB2, INPP5D and SHC1 upon phosphorylation (By similarity). May form a complex with INPP5D/SHIP, GRB2 and SHC1.

Function:

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

847

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

847:

KRQVGDYENV | IPDFPEDEGI | HYSELIQFGV | GERPQAQENV | DYVILKH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF08205

String:

P20273

KEGG:

hsa:933

UniGene:

Hs.579691

MIM:

107266

SMR:

P20273

Uniprot:

P20273

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ELISA Kit for Human B-cell receptor CD22

Cat.:

E1513h

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Manual:

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96T

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ELISA Kit for Human B-cell receptor CD22

Cat.:

E1513m

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MSDS:

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Packing:

96T

CLIA Kit for Human B-cell receptor CD22

Cat.:

U1513m

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Packing:

96T

CLIA Kit for Human B-cell receptor CD22

Cat.:

U1513h

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Packing:

96T

Polyclonal Antibody for Human B-cell receptor CD22

Cat.:

P1513Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human B-cell receptor CD22

Cat.:

P1513Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human B-cell receptor CD22

Protein for Human B-cell receptor CD22

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The B-cell antigen CD22 mediates monocyte and erythrocyte adhesion."
Stamenkovic I. , Seed B.
Nature345:74-77(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD22-BETA)
2.

"cDNA cloning of the B cell membrane protein CD22: a mediator of B-B cell interactions."
Wilson G.L. , Fox C.H. , Fauci A.S. , Kehrl J.H.
J. Exp. Med.173:137-146(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CD22-BETA);VARIANT HIS-639
tissue: Tonsil.
3.

"Genomic structure and chromosomal mapping of the human CD22 gene."
Wilson G.L. , Najfeld V. , Kozlow E. , Menniger J. , Ward D. , Kehrl J.H.
J. Immunol.150:5013-5024(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS CD22-ALPHA AND CD22-BETA)
4.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2006-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Spleen.
5.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
7.

"Identification of the gene variations in human CD22."
Hatta Y. , Tsuchiya N. , Matsushita M. , Shiota M. , Hagiwara K. , Tokunaga K.
Immunogenetics49:280-286(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-137; 139-239; 241-328 AND 418-502;VARIANTS THR-34; GLU-152; LYS-203; GLY-664; CYS-669 AND ASP-745
8.

"Natural ligands of the B cell adhesion molecule CD22 beta carry N-linked oligosaccharides with alpha-2,6-linked sialic acids that are required for recognition."
Powell L.D. , Sgroi D. , Sjoberg E.R. , Stamenkovic I. , Varki A.
J. Biol. Chem.268:7019-7027(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIALIC ACID-BINDING
9.

"A role in B cell activation for CD22 and the protein tyrosine phosphatase SHP."
Doody G.M. , Justement L.B. , Delibrias C.C. , Matthews R.J. , Lin J. , Thomas M.L. , Fearon D.T.
Science269:242-244(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN6
10.

"Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22."
Tuscano J.M. , Engel P. , Tedder T.F. , Agarwal A. , Kehrl J.H.
Eur. J. Immunol.26:1246-1252(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH LYN; SYK AND PIK3R1/PIK3R2
11.

"CD22 associates with protein tyrosine phosphatase 1C, Syk, and phospholipase C-gamma(1) upon B cell activation."
Law C.L. , Sidorenko S.P. , Chandran K.A. , Zhao Z. , Shen S.H. , Fischer E.H. , Clark E.A.
J. Exp. Med.183:547-560(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTPN6; SYK AND PLCG1
12.

"CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling."
Tedder T.F. , Tuscano J. , Sato S. , Kehrl J.H.
Annu. Rev. Immunol.15:481-504(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW

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