Gene name:
CD276 (PSEC0249;UNQ309/PRO352;B7H3) ;
Protein name:
CD276 antigen ;
Alternative:
B7 homolog 3 (B7-H3) ;4Ig-B7-H3 ;Costimulatory molecule ;
CD:
CD276 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with TREML2 and this interaction enhances T-cell activation.
Function:
May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MLRRRGSPGM | GVHVGAALGA | LWFCLTGALE | VQVPEDPVVA | LVGTDATLCC |
100:
SFSPEPGFSL | AQLNLIWQLT | DTKQLVHSFA | EGQDQGSAYA | NRTALFPDLL |
150:
AQGNASLRLQ | RVRVADEGSF | TCFVSIRDFG | SAAVSLQVAA | PYSKPSMTLE |
200:
PNKDLRPGDT | VTITCSSYQG | YPEAEVFWQD | GQGVPLTGNV | TTSQMANEQG |
250:
LFDVHSILRV | VLGANGTYSC | LVRNPVLQQD | AHSSVTITPQ | RSPTGAVEVQ |
300:
VPEDPVVALV | GTDATLRCSF | SPEPGFSLAQ | LNLIWQLTDT | KQLVHSFTEG |
350:
RDQGSAYANR | TALFPDLLAQ | GNASLRLQRV | RVADEGSFTC | FVSIRDFGSA |
400:
AVSLQVAAPY | SKPSMTLEPN | KDLRPGDTVT | ITCSSYRGYP | EAEVFWQDGQ |
450:
GVPLTGNVTT | SQMANEQGLF | DVHSVLRVVL | GANGTYSCLV | RNPVLQQDAH |
500:
GSVTITGQPM | TFPPEALWVT | VGLSVCLIAL | LVALAFVCWR | KIKQSCEEEN |
534:
AGAEDQDGEG | EGSKTALQPL | KHSDSKEDDG | QEIA
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human CD276 antigen
ELISA Kit for Human CD276 antigen
ELISA Kit for Human CD276 antigen
CLIA Kit for Human CD276 antigen
CLIA Kit for Human CD276 antigen
CLIA Kit for Human CD276 antigen
Polyclonal Antibody for Human CD276 antigen
Polyclonal Antibody for Human CD276 antigen
Polyclonal Antibody for Human CD276 antigen
Monoclonal Antibody for Human CD276 antigen
Monoclonal Antibody for Human CD276 antigen
Monoclonal Antibody for Human CD276 antigen
Protein for Human CD276 antigen
Protein for Human CD276 antigen
Protein for Human CD276 antigen
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;FUNCTION
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-534 (ISOFORM 1);VARIANT MET-160
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT MET-160
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Lung .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 29-43
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;GENOMIC DOMAIN DUPLICATION
9.
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Proc. Natl. Acad. Sci. U.S.A.101:12640-12645(2004)
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PubMed ]
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Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INDUCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TREML2
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ERRATUM
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-322 AND ASN-407
tissue :
Liver .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]