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Index > Protein center > CD276(Gene name) > Human
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  • CD276 (Gene name),
  • CD276 antigen (Protein name ),  CD276_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    CD276(PSEC0249;UNQ309/PRO352;B7H3);
    Protein name:
    CD276 antigen;
    Alternative:
    B7 homolog 3(B7-H3);4Ig-B7-H3;Costimulatory molecule;
    CD:
    CD276;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with TREML2 and this interaction enhances T-cell activation.
    Function:
    May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    534
    Sequence:
    50:
    MLRRRGSPGM | GVHVGAALGA | LWFCLTGALE | VQVPEDPVVA | LVGTDATLCC | 
    100:
    SFSPEPGFSL | AQLNLIWQLT | DTKQLVHSFA | EGQDQGSAYA | NRTALFPDLL | 
    150:
    AQGNASLRLQ | RVRVADEGSF | TCFVSIRDFG | SAAVSLQVAA | PYSKPSMTLE | 
    200:
    PNKDLRPGDT | VTITCSSYQG | YPEAEVFWQD | GQGVPLTGNV | TTSQMANEQG | 
    250:
    LFDVHSILRV | VLGANGTYSC | LVRNPVLQQD | AHSSVTITPQ | RSPTGAVEVQ | 
    300:
    VPEDPVVALV | GTDATLRCSF | SPEPGFSLAQ | LNLIWQLTDT | KQLVHSFTEG | 
    350:
    RDQGSAYANR | TALFPDLLAQ | GNASLRLQRV | RVADEGSFTC | FVSIRDFGSA | 
    400:
    AVSLQVAAPY | SKPSMTLEPN | KDLRPGDTVT | ITCSSYRGYP | EAEVFWQDGQ | 
    450:
    GVPLTGNVTT | SQMANEQGLF | DVHSVLRVVL | GANGTYSCLV | RNPVLQQDAH | 
    500:
    GSVTITGQPM | TFPPEALWVT | VGLSVCLIAL | LVALAFVCWR | KIKQSCEEEN | 
    534:
    AGAEDQDGEG | EGSKTALQPL | KHSDSKEDDG | QEIA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    String:
    KEGG:
    MIM:
    UniGene:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human CD276 antigen
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    E8942m
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    ELISA Kit for Human CD276 antigen
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    E8942r
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    ELISA Kit for Human CD276 antigen
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    E8942h
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    CLIA Kit for Human CD276 antigen
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    U8942h
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    Packing:
    96T
    Range:
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    CLIA Kit for Human CD276 antigen
    Cat.:
    U8942r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CD276 antigen
    Cat.:
    U8942m
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human CD276 antigen
    Cat.:
    P8942Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CD276 antigen
    Cat.:
    P8942Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CD276 antigen
    Monoclonal Antibody for Human CD276 antigen
    Monoclonal Antibody for Human CD276 antigen
    Monoclonal Antibody for Human CD276 antigen
    Protein for Human CD276 antigen
    Protein for Human CD276 antigen
    Protein for Human CD276 antigen

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    Linearity
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    References
    1. 1.
      "B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production."
      Chapoval A.I. , Ni J. , Lau J.S. , Wilcox R.A. , Flies D.B. , Liu D. , Dong H. , Sica G.L. , Zhu G. , Tamada K. , Chen L.
      Nat. Immunol.2:269-274(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;FUNCTION
    2. 2.
      "Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains."
      Steinberger P. , Majdic O. , Derdak S.V. , Pfistershammer K. , Kirchberger S. , Klauser C. , Zlabinger G. , Pickl W.F. , Stockl J. , Knapp W.
      J. Immunol.172:2352-2359(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;FUNCTION;INDUCTION
    3. 3.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 91-534 (ISOFORM 1);VARIANT MET-160
    5. 5.
      "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries."
      Otsuki T. , Ota T. , Nishikawa T. , Hayashi K. , Suzuki Y. , Yamamoto J. , Wakamatsu A. , Kimura K. , Sakamoto K. , Hatano N. , Kawai Y. , Ishii S. , Saito K. , Kojima S. , Sugiyama T. , Ono T. , Okano K. , Yoshikawa Y. , more...
      DNA Res.12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT MET-160
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Lung.
    7. 7.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-43
    8. 8.
      "Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss."
      Ling V. , Wu P.W. , Spaulding V. , Kieleczawa J. , Luxenberg D. , Carreno B.M. , Collins M.
      Genomics82:365-377(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;GENOMIC DOMAIN DUPLICATION
    9. 9.
      "Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis."
      Castriconi R. , Dondero A. , Augugliaro R. , Cantoni C. , Carnemolla B. , Sementa A.R. , Negri F. , Conte R. , Corrias M.V. , Moretta L. , Moretta A. , Bottino C.
      Proc. Natl. Acad. Sci. U.S.A.101:12640-12645(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "The immunomodulatory proteins B7-DC, B7-H2, and B7-H3 are differentially expressed across gestation in the human placenta."
      Petroff M.G. , Kharatyan E. , Torry D.S. , Holets L.
      Am. J. Pathol.167:465-473(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    11. 11.
      "Constitutive and inducible expression of B7 family of ligands by human airway epithelial cells."
      Kim J. , Myers A.C. , Chen L. , Pardoll D.M. , Truong-Tran Q.A. , Lane A.P. , McDyer J.F. , Fortuno L. , Schleimer R.P.
      Am. J. Respir. Cell Mol. Biol.33:280-289(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    13. 13.
      "B7-H3 promotes acute and chronic allograft rejection."
      Wang L. , Fraser C.C. , Kikly K. , Wells A.D. , Han R. , Coyle A.J. , Chen L. , Hancock W.W.
      Eur. J. Immunol.35:428-438(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
    14. 14.
      "Triggering receptor expressed on myeloid cell-like transcript 2 (TLT-2) is a counter-receptor for B7-H3 and enhances T cell responses."
      Hashiguchi M. , Kobori H. , Ritprajak P. , Kamimura Y. , Kozono H. , Azuma M.
      Proc. Natl. Acad. Sci. U.S.A.105:10495-10500(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TREML2
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-525;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-322 AND ASN-407
      tissue: Liver.
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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