Protein name:
T-cell surface glycoprotein CD4 ;
Alternative:
T-cell surface antigen T4/Leu-3 ;
CD:
CD4 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI-CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2; this interaction requires the presence of HIV-1 gp120.
Function:
Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
Protein Attributes:
50:
MNRGVPFRHL | LLVLQLALLP | AATQGKKVVL | GKKGDTVELT | CTASQKKSIQ |
100:
FHWKNSNQIK | ILGNQGSFLT | KGPSKLNDRA | DSRRSLWDQG | NFPLIIKNLK |
150:
IEDSDTYICE | VEDQKEEVQL | LVFGLTANSD | THLLQGQSLT | LTLESPPGSS |
200:
PSVQCRSPRG | KNIQGGKTLS | VSQLELQDSG | TWTCTVLQNQ | KKVEFKIDIV |
250:
VLAFQKASSI | VYKKEGEQVE | FSFPLAFTVE | KLTGSGELWW | QAERASSSKS |
300:
WITFDLKNKE | VSVKRVTQDP | KLQMGKKLPL | HLTLPQALPQ | YAGSGNLTLA |
350:
LEAKTGKLHQ | EVNLVVMRAT | QLQKNLTCEV | WGPTSPKLML | SLKLENKEAK |
400:
VSKREKAVWV | LNPEAGMWQC | LLSDSGQVLL | ESNIKVLPTW | STPVQPMALI |
450:
VLGGVAGLLL | FIGLGIFFCV | RCRHRRRQAE | RMSQIKRLLS | EKKTCQCPHR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Rabbit
Mouse
Dog
ELISA Kit for Human T-cell surface glycoprotein CD4
ELISA Kit for Human T-cell surface glycoprotein CD4
ELISA Kit for Human T-cell surface glycoprotein CD4
ELISA Kit for Human T-cell surface glycoprotein CD4
ELISA Kit for Human T-cell surface glycoprotein CD4
CLIA Kit for Human T-cell surface glycoprotein CD4
CLIA Kit for Human T-cell surface glycoprotein CD4
CLIA Kit for Human T-cell surface glycoprotein CD4
CLIA Kit for Human T-cell surface glycoprotein CD4
CLIA Kit for Human T-cell surface glycoprotein CD4
Polyclonal Antibody for Human T-cell surface glycoprotein CD4
Polyclonal Antibody for Human T-cell surface glycoprotein CD4
Polyclonal Antibody for Human T-cell surface glycoprotein CD4
Polyclonal Antibody for Human T-cell surface glycoprotein CD4
Polyclonal Antibody for Human T-cell surface glycoprotein CD4
Monoclonal Antibody for Human T-cell surface glycoprotein CD4
Monoclonal Antibody for Human T-cell surface glycoprotein CD4
Monoclonal Antibody for Human T-cell surface glycoprotein CD4
Monoclonal Antibody for Human T-cell surface glycoprotein CD4
Monoclonal Antibody for Human T-cell surface glycoprotein CD4
Protein for Human T-cell surface glycoprotein CD4
Protein for Human T-cell surface glycoprotein CD4
Protein for Human T-cell surface glycoprotein CD4
Protein for Human T-cell surface glycoprotein CD4
Protein for Human T-cell surface glycoprotein CD4
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Thymus .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLU-191; SER-227 AND TRP-265
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Pancreas .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 28-424
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Blood .
12.
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Cited for : PROTEIN SEQUENCE OF 26-394;DISULFIDE BOND
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Cited for : PROTEIN SEQUENCE OF 26-40
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 250-280;POLYMORPHISM;VARIANT TRP-265
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HIV-1 ENVELOPE POLYPROTEIN GP160
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION AT ASN-296 AND ASN-325
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REMOVAL FROM CELL SURFACE BY HIV-1 NEF;MUTAGENESIS OF MET-432; SER-433; 438-LEU-LEU-439 AND SER-440
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SPG21;MUTAGENESIS OF 457-PRO-ILE-458
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HIV-1 SURFACE PROTEIN GP120
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-296
tissue :
Liver .
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 26-208
25.
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Nature348:419-426(1990)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 26-208
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.9 ANGSTROMS) OF 26-388
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 26-208 IN COMPLEX WITH HIV SURFACE PROTEIN GP120
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.82 ANGSTROMS) OF 428-450 IN COMPLEX WITH PTK2/FAK1;INTERACTION WITH PTK2/FAK1