Gene name:
CDK5R1 (CDK5R;NCK5A) ;
Protein name:
Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) ;
Alternative:
TPKII regulatory subunit ;Cyclin-dependent kinase 5 regulatory subunit 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer composed of a catalytic subunit CDK5 and a regulatory subunit CDK5R1 (p25) and macromolecular complex composed of at least CDK5, CDK5R1 (p35) and CDK5RAP1 or CDK5RAP2 or CDK5RAP3. Only the heterodimer shows kinase activity. Interacts with EPHA4 and NGEF; may mediate the activation of NGEF by EPHA4 (By similarity). Interacts with RASGRF2.
Function:
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII.
Subcellular Location:
Cyclin-dependent kinase 5 activator 1, p25
Nucleus
Cytoplasm
perinuclear region
The conversion of p35 to p25 relocalizes the protein from the cell periphery to the cytoplasm, in nuclear and perinuclear regions. In the primary cortical neurons, p25 is primarily concentrated in the cell soma and is largely absent from neurites.
Protein Attributes:
50:
MGTVLSLSPS | YRKATLFEDG | AATVGHYTAV | QNSKNAKDKN | LKRHSIISVL |
100:
PWKRIVAVSA | KKKNSKKVQP | NSSYQNNITH | LNNENLKKSL | SCANLSTFAQ |
150:
PPPAQPPAPP | ASQLSGSQTG | GSSSVKKAPH | PAVTSAGTPK | RVIVQASTSE |
200:
LLRCLGEFLC | RRCYRLKHLS | PTDPVLWLRS | VDRSLLLQGW | QDQGFITPAN |
250:
VVFLYMLCRD | VISSEVGSDH | ELQAVLLTCL | YLSYSYMGNE | ISYPLKPFLV |
300:
ESCKEAFWDR | CLSVINLMSS | KMLQINADPH | YFTQVFSDLK | NESGQEDKKR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Bovine
Mouse
ELISA Kit for Human CDK5 activator 1
ELISA Kit for Human CDK5 activator 1
ELISA Kit for Human CDK5 activator 1
ELISA Kit for Human CDK5 activator 1
CLIA Kit for Human CDK5 activator 1
CLIA Kit for Human CDK5 activator 1
CLIA Kit for Human CDK5 activator 1
CLIA Kit for Human CDK5 activator 1
Polyclonal Antibody for Human CDK5 activator 1
Polyclonal Antibody for Human CDK5 activator 1
Polyclonal Antibody for Human CDK5 activator 1
Polyclonal Antibody for Human CDK5 activator 1
Monoclonal Antibody for Human CDK5 activator 1
Monoclonal Antibody for Human CDK5 activator 1
Monoclonal Antibody for Human CDK5 activator 1
Monoclonal Antibody for Human CDK5 activator 1
Protein for Human CDK5 activator 1
Protein for Human CDK5 activator 1
Protein for Human CDK5 activator 1
Protein for Human CDK5 activator 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Mammary gland .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : MUTAGENESIS OF GLY-2;SUBCELLULAR LOCATION;INVOLVEMENT IN NEURODEGENERATIVE DISEASES
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION BY CDK5;UBIQUITINATION
8.
"p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent extracellular signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in neurons."
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J. Neurosci.24:4421-4431(2004)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH RASGRF2
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-8 AND THR-138;MUTAGENESIS OF SER-8 AND THR-138
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION BY CDK5;INTERACTION WITH CDK5;SUBCELLULAR LOCATION
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;MYRISTOYLATION;MUTAGENESIS OF GLY-2
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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J. Biol. Chem.288:36878-36889(2013)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH CLOCK
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 145-293 IN COMPLEX WITH CDK5
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 100-307 IN COMPLEX WITH CDK5 AND INHIBITORS