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Index > Protein center > CD63(Gene name) > Human
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  • CD63 (Gene name),
  • CD63 antigen (Protein name ),  CD63_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    CD63(MLA1;TSPAN30);
    Protein name:
    CD63 antigen;
    Alternative:
    Lysosomal-associated membrane protein 3(LAMP-3);Granulophysin;OMA81H;Melanoma-associated antigen ME491;Tetraspanin-30(Tspan-30);Ocular melanoma-associated antigen;
    CD:
    CD63;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    This antigen is associated with early stages of melanoma tumor progression. May play a role in growth regulation.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Lysosome membrane Multi-pass membrane protein Late endosome membrane Multi-pass membrane protein Also found in Weibel-Palade bodies of endothelial cells. Located in platelet dense granules.
    Protein Attributes:
    Sequence length:
    238
    Sequence:
    50:
    MAVEGGMKCV | KFLLYVLLLA | FCACAVGLIA | VGVGAQLVLS | QTIIQGATPG | 
    100:
    SLLPVVIIAV | GVFLFLVAFV | GCCGACKENY | CLMITFAIFL | SLIMLVEVAA | 
    150:
    AIAGYVFRDK | VMSEFNNNFR | QQMENYPKNN | HTASILDRMQ | ADFKCCGAAN | 
    200:
    YTDWEKIPSM | SKNRVPDSCC | INVTVGCGIN | FNEKAIHKEG | CVEKIGGWLR | 
    238:
    KNVLVVAAAA | LGIAFVEVLG | IVFACCLVKS | IRSGYEVM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    Pfam:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human CD63 antigen
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    E9307m
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    Packing:
    96T
    ELISA Kit for Human CD63 antigen
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    E9307r
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    96T
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    ELISA Kit for Human CD63 antigen
    MSDS:
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    ELISA Kit for Human CD63 antigen
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    E9307h
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    Packing:
    96T
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    ELISA Kit for Human CD63 antigen
    Cat.:
    E9307b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human CD63 antigen
    Cat.:
    U9307r
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    Packing:
    96T
    CLIA Kit for Human CD63 antigen
    Cat.:
    U9307h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human CD63 antigen
    Cat.:
    U9307b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human CD63 antigen
    MSDS:
    Please sign in first.
    CLIA Kit for Human CD63 antigen
    Cat.:
    U9307m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human CD63 antigen
    Polyclonal Antibody for Human CD63 antigen
    Cat.:
    P9307Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CD63 antigen
    Cat.:
    P9307Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human CD63 antigen
    Polyclonal Antibody for Human CD63 antigen
    Monoclonal Antibody for Human CD63 antigen
    Monoclonal Antibody for Human CD63 antigen
    Monoclonal Antibody for Human CD63 antigen
    Monoclonal Antibody for Human CD63 antigen
    Monoclonal Antibody for Human CD63 antigen
    Protein for Human CD63 antigen
    Protein for Human CD63 antigen
    Protein for Human CD63 antigen
    Protein for Human CD63 antigen
    Protein for Human CD63 antigen

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and characterization of an antigen associated with early stages of melanoma tumor progression."
      Hotta H. , Ross A.H. , Huebner K. , Isobe M. , Wendeborn S. , Chao M.V. , Ricciardi R.P. , Tsujimoto Y. , Croce C.M. , Koprowski H.
      Cancer Res.48:2955-2962(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Characterization of three abundant mRNAs from human ovarian granulosa cells."
      Rapp G. , Freudenstein J. , Klaudiny J. , Mucha J. , Wempe F. , Zimmer M. , Scheit K.H.
      DNA Cell Biol.9:479-485(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Ovary.
    3. 3.
      "CD63 antigen. A novel lysosomal membrane glycoprotein, cloned by a screening procedure for intracellular antigens in eukaryotic cells."
      Metzelaar M.J. , Wigngaard P.L. , Peters P.J. , Sixma J.J. , Nieuwenhuis H.K. , Clevers H.C.
      J. Biol. Chem.266:3239-3245(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION
    4. 4.
      "An ocular melanoma-associated antigen. Molecular characterization."
      Wang M.X. , Earley J.J. Jr. , Shields J.A. , Donoso L.A.
      Arch. Ophthalmol.110:399-404(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      "Genomic structure of the ME491/CD63 antigen gene and functional analysis of the 5'-flanking regulatory sequences."
      Hotta H. , Miyamoto H. , Hara I. , Takahashi N. , Homma M.
      Biochem. Biophys. Res. Commun.185:436-442(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "Melanocyte variant of lysosome-associated membrane protein-3 (LAMP3; also CD63 and melanoma associated antigen ME419) mRNA."
      Ancans J. , Suzuki I. , Thody A.J.
      Submitted (2002-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Skin.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Skeletal muscle.
    8. 8.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    9. 9.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2004-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    10. 10.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    12. 12.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lung.
      tissue: Muscle.
    13. 13.
      "The protein CD63 is in platelet dense granules, is deficient in a patient with Hermansky-Pudlak syndrome, and appears identical to granulophysin."
      Nishibori M. , Cham B. , McNicol A. , Shalev A. , Jain N. , Gerrard J.M.
      J. Clin. Invest.91:1775-1782(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-38 (ISOFORM 1);SUBCELLULAR LOCATION;LACK OF EXPRESSION IN HERMANSKY-PUDLAK SYNDROME
      tissue: Platelet.
    14. 14.
      "Isolation and amino terminal sequencing of a novel melanoma-associated antigen."
      Ross A.H. , Dietzschold B. , Jackson D.M. , Earley J.J. , Ghrist B.F.D. , Atkinson B. , Koprowski H.
      Arch. Biochem. Biophys.242:540-548(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-21 (ISOFORMS 1/2)
    15. 15.
      "The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells."
      Kobayashi T. , Vischer U.M. , Rosnoblet C. , Lebrand C. , Lindsay M. , Parton R.G. , Kruithof E.K.O. , Gruenberg J.
      Mol. Biol. Cell11:1829-1843(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    16. 16.
      "Identification and quantification of N-linked glycoproteins using hydrazide chemistry, stable isotope labeling and mass spectrometry."
      Zhang H. , Li X.-J. , Martin D.B. , Aebersold R.
      Nat. Biotechnol.21:660-666(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-130
    17. 17.
      "LAMP-1 and LAMP-2, but not LAMP-3, are reliable markers for activation-induced secretion of human mast cells."
      Gruetzkau A. , Smorodchenko A. , Lippert U. , Kirchhof L. , Artuc M. , Henz B.M.
      Cytometry61:62-68(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    18. 18.
      "Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein."
      Jung K.K. , Liu X.W. , Chirco R. , Fridman R. , Kim H.R.
      EMBO J.25:3934-3942(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH TIMP1 AND ITGB1
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Placenta.
    20. 20.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-130
      tissue: Liver.
    21. 21.
      "Palmitoylation supports the association of tetraspanin CD63 with CD9 and integrin alphaIIbbeta3 in activated platelets."
      Israels S.J. , McMillan-Ward E.M.
      Thromb. Res.125:152-158(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;INTERACTION WITH CD9;IDENTIFICATION IN A COMPLEX WITH ITGB3
    22. 22.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    23. 23.
      "CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin."
      Doyle E.L. , Ridger V. , Ferraro F. , Turmaine M. , Saftig P. , Cutler D.F.
      Blood118:4265-4273(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL-CELL ADHESION;SUBCELLULAR LOCATION
    24. 24.
      "The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis."
      van Niel G. , Charrin S. , Simoes S. , Romao M. , Rochin L. , Saftig P. , Marks M.S. , Rubinstein E. , Raposo G.
      Dev. Cell21:708-721(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MELANOCYTE DEVELOPMENT;SUBCELLULAR LOCATION;INTERACTION WITH PMEL
    25. 25.
      "Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-beta1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo."
      Tugues S. , Honjo S. , Konig C. , Padhan N. , Kroon J. , Gualandi L. , Li X. , Barkefors I. , Thijssen V.L. , Griffioen A.W. , Claesson-Welsh L.
      J. Biol. Chem.288:19060-19071(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH KDR
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      "TIMP-1 modulates chemotaxis of human neural stem cells through CD63 and integrin signalling."
      Lee S.Y. , Kim J.M. , Cho S.Y. , Kim H.S. , Shin H.S. , Jeon J.Y. , Kausar R. , Jeong S.Y. , Lee Y.S. , Lee M.A.
      Biochem. J.459:565-576(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CD63 AND ITGB1
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