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Index > Protein center > CDKN2C(Gene name) > Human
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  • CDKN2C (Gene name),
  • Cyclin-dependent kinase 4 inhibitor C (Protein name ),  CDN2C_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CDKN2C(CDKN6);
    Protein name:
    Cyclin-dependent kinase 4 inhibitor C;
    Alternative:
    p18-INK4c;Cyclin-dependent kinase 6 inhibitor;p18-INK6;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of p18 with CDK6.
    Function:
    Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
    Subcellular Location:
    Protein Attributes:
    Sequence length:
    168
    Sequence:
    50:
    MAEPWGNELA | SAAARGDLEQ | LTSLLQNNVN | VNAQNGFGRT | ALQVMKLGNP | 
    100:
    EIARRLLLRG | ANPDLKDRTG | FAVIHDAARA | GFLDTLQTLL | EFQADVNIED | 
    150:
    NEGNLPLHLA | AKEGHLRVVE | FLVKHTASNV | GHRNHKGDTA | CDLARLYGRN | 
    168:
    EVVSLMQANG | AGGATNLQ
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    UniGene:
    Pfam:
    MIM:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cyclin-dependent kinase 4 inhibitor C
    Cat.:
    E1943h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Cyclin-dependent kinase 4 inhibitor C
    Cat.:
    E1943m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cyclin-dependent kinase 4 inhibitor C
    Cat.:
    U1943m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Cyclin-dependent kinase 4 inhibitor C
    Cat.:
    U1943h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Cyclin-dependent kinase 4 inhibitor C
    Cat.:
    P1943Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Cyclin-dependent kinase 4 inhibitor C
    Cat.:
    P1943Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cyclin-dependent kinase 4 inhibitor C
    Monoclonal Antibody for Human Cyclin-dependent kinase 4 inhibitor C
    Protein for Human Cyclin-dependent kinase 4 inhibitor C
    Protein for Human Cyclin-dependent kinase 4 inhibitor C

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function."
      Guan K.-L. , Jenkins C.W. , Li Y. , Nichols M.A. , Wu X. , O'Keefe C.L. , Matera G.A. , Xiong Y.
      Genes Dev.8:2939-2952(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer."
      Blais A. , Labrie Y. , Pouliot F. , Lachance Y. , Labrie C.
      Biochem. Biophys. Res. Commun.247:146-153(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];VARIANT BREAST CANCER PRO-72
      tissue: Mammary gland.
    3. 3.
      NIEHS SNPs program
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-126
      tissue: Brain.
      tissue: Kidney.
      tissue: Uterus.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    6. 6.
      "Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations."
      Venkataramani R. , Swaminathan K. , Marmorstein R.
      Nat. Struct. Biol.5:74-81(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS)
    7. 7.
      "Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A."
      Li J. , Byeon I.-J.L. , Ericson K. , Poi M.-J. , O'Maille P. , Selby T. , Tsai M.-D.
      Biochemistry38:2930-2940(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    8. 8.
      "A p18 mutant defective in CDK6 binding in human breast cancer cells."
      Lapointe J. , Lachance Y. , Labrie Y. , Labrie C.
      Cancer Res.56:4586-4589(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BREAST CANCER PRO-72
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