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Index > Protein center > CEBPB(Gene name) > Human
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  • CEBPB (Gene name),
  • CCAAT/enhancer-binding protein beta (Protein name ),  CEBPB_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    CEBPB(PP9092;PP9092;LAP;TCF5);
    Protein name:
    CCAAT/enhancer-binding protein beta(C/EBP beta);
    Alternative:
    Nuclear factor NF-IL6(LIP);Liver activator protein(LAP);Transcription factor 5(TCF-5);Transcription factor 5(TCF-5);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms a complex with THOC5.
    Function:
    Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    345
    Sequence:
    50:
    MQRLVAWDPA | CLPLPPPPPA | FKSMEVANFY | YEADCLAAAY | GGKAAPAAPP | 
    100:
    AARPGPRPPA | GELGSIGDHE | RAIDFSPYLE | PLGAPQAPAP | ATATDTFEAA | 
    150:
    PPAPAPAPAS | SGQHHDFLSD | LFSDDYGGKN | CKKPAEYGYV | SLGRLGAAKG | 
    200:
    ALHPGCFAPL | HPPPPPPPPP | AELKAEPGFE | PADCKRKEEA | GAPGGGAGMA | 
    250:
    AGFPYALRAY | LGYQAVPSGS | SGSLSTSSSS | SPPGTPSPAD | AKAPPTACYA | 
    300:
    GAAPAPSQVK | SKAKKTVDKH | SDEYKIRRER | NNIAVRKSRD | KAKMRNLETQ | 
    345:
    HKVLELTAEN | ERLQKKVEQL | SRELSTLRNL | FKQLPEPLLA | SSGHC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    SMR:
    KEGG:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human C/EBP beta
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    ELISA Kit for Human C/EBP beta
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    ELISA Kit for Human C/EBP beta
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    ELISA Kit for Human C/EBP beta
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    ELISA Kit for Human C/EBP beta
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    CLIA Kit for Human C/EBP beta
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    CLIA Kit for Human C/EBP beta
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    Polyclonal Antibody for Human C/EBP beta
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    P0713Rb-r
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    Polyclonal Antibody for Human C/EBP beta
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    Polyclonal Antibody for Human C/EBP beta
    Polyclonal Antibody for Human C/EBP beta
    Polyclonal Antibody for Human C/EBP beta
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    Packing:
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    Monoclonal Antibody for Human C/EBP beta
    Monoclonal Antibody for Human C/EBP beta
    Monoclonal Antibody for Human C/EBP beta
    Monoclonal Antibody for Human C/EBP beta
    Monoclonal Antibody for Human C/EBP beta
    Protein for Human C/EBP beta
    Protein for Human C/EBP beta
    Protein for Human C/EBP beta
    Protein for Human C/EBP beta
    Protein for Human C/EBP beta

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    References
    1. 1.
      "A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family."
      Akira S. , Isshiki H. , Sugita T. , Tanabe O. , Kinoshita S. , Nishio Y. , Nakajima T. , Hirano T. , Kishimoto T.
      EMBO J.9:1897-1906(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    2. 2.
      "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
      Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 3.
      SeattleSNPs variation discovery resource
      Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT SER-195
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Placenta.
    5. 5.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Muscle.
      tissue: Skin.
    8. 8.
      "Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family."
      Toda K. , Akira S. , Kishimoto T. , Sasaki H. , Hashimoto K. , Yamamoto Y. , Sagara Y. , Shizuta Y.
      Eur. J. Biochem.231:292-299(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 241-323 (ISOFORMS 1/2/3)
    9. 9.
      "C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival."
      Buck M. , Poli V. , Hunter T. , Chojkier M.
      Mol. Cell8:807-816(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-235
    10. 10.
      "Dynamic regulation of cyclooxygenase-2 promoter activity by isoforms of CCAAT/enhancer-binding proteins."
      Zhu Y. , Saunders M.A. , Yeh H. , Deng W.G. , Wu K.K.
      J. Biol. Chem.277:6923-6928(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 3);ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3);DNA-BINDING
    11. 11.
      "Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3."
      Eaton E.M. , Sealy L.
      J. Biol. Chem.278:33416-33421(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-174
    12. 12.
      "Nine-amino-acid transactivation domain: establishment and prediction utilities."
      Piskacek S. , Gregor M. , Nemethova M. , Grabner M. , Kovarik P. , Piskacek M.
      Genomics89:756-768(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN
    13. 13.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma."
      Park S.H. , Choi H.J. , Yang H. , Do K.H. , Kim J. , Lee D.W. , Moon Y.
      J. Biol. Chem.285:35330-35339(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DDIT3;SUBCELLULAR LOCATION;INDUCTION
    15. 15.
      "Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta."
      Tahirov T.H. , Inoue-Bungo T. , Morii H. , Fujikawa A. , Sasaki M. , Kimura K. , Shiina M. , Sato K. , Kumasaka T. , Yamamoto M. , Ishii S. , Ogata K.
      Cell104:755-767(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 259-336 IN COMPLEX WITH RUNX1; CBFB AND DNA
    16. 16.
      "Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter."
      Tahirov T.H. , Sato K. , Ichikawa-Iwata E. , Sasaki M. , Inoue-Bungo T. , Shiina M. , Kimura K. , Takata S. , Fujikawa A. , Morii H. , Kumasaka T. , Yamamoto M. , Ishii S. , Ogata K.
      Cell108:57-70(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 259-345 IN COMPLEX WITH MOUSE MYB
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