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Index > Protein center > CERK(Gene name) > Human
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  • CERK (Gene name),
  • Ceramide kinase (Protein name ),  CERK1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    CERK(KIAA1646);
    Protein name:
    Ceramide kinase(hCERK);
    Alternative:
    Lipid kinase 4(LK4);Acylsphingosine kinase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides.
    Subcellular Location:
    Cytoplasm Membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    537
    Sequence:
    50:
    MGATGAAEPL | QSVLWVKQQR | CAVSLEPARA | LLRWWRSPGP | GAGAPGADAC | 
    100:
    SVPVSEIIAV | EETDVHGKHQ | GSGKWQKMEK | PYAFTVHCVK | RARRHRWKWA | 
    150:
    QVTFWCPEEQ | LCHLWLQTLR | EMLEKLTSRP | KHLLVFINPF | GGKGQGKRIY | 
    200:
    ERKVAPLFTL | ASITTDIIVT | EHANQAKETL | YEINIDKYDG | IVCVGGDGMF | 
    250:
    SEVLHGLIGR | TQRSAGVDQN | HPRAVLVPSS | LRIGIIPAGS | TDCVCYSTVG | 
    300:
    TSDAETSALH | IVVGDSLAMD | VSSVHHNSTL | LRYSVSLLGY | GFYGDIIKDS | 
    350:
    EKKRWLGLAR | YDFSGLKTFL | SHHCYEGTVS | FLPAQHTVGS | PRDRKPCRAG | 
    400:
    CFVCRQSKQQ | LEEEQKKALY | GLEAAEDVEE | WQVVCGKFLA | INATNMSCAC | 
    450:
    RRSPRGLSPA | AHLGDGSSDL | ILIRKCSRFN | FLRFLIRHTN | QQDQFDFTFV | 
    500:
    EVYRVKKFQF | TSKHMEDEDS | DLKEGGKKRF | GHICSSHPSC | CCTVSNSSWN | 
    537:
    CDGEVLHSPA | IEVRVHCQLV | RLFARGIEEN | PKPDSHS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    String:
    MIM:
    Pfam:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human hCERK
    Cat.:
    E13782h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human hCERK
    Cat.:
    E13782m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human hCERK
    Cat.:
    U13782h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human hCERK
    Cat.:
    U13782m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human hCERK
    Polyclonal Antibody for Human hCERK
    Monoclonal Antibody for Human hCERK
    Monoclonal Antibody for Human hCERK
    Protein for Human hCERK
    Protein for Human hCERK

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization."
      Sugiura M. , Kono K. , Liu H. , Shimizugawa T. , Minekura H. , Spiegel S. , Kohama T.
      J. Biol. Chem.277:23294-23300(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);CHARACTERIZATION
      tissue: Leukemia.
    2. 2.
      "A search for lipid kinases."
      Van Veldhoven P.P.
      Submitted (2002-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: PNS.
    8. 8.
      "Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping."
      Hirosawa M. , Nagase T. , Murahashi Y. , Kikuno R. , Ohara O.
      DNA Res.8:1-9(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 57-537 (ISOFORM 1)
      tissue: Brain.
    9. 9.
      "The leucine 10 residue in the pleckstrin homology domain of ceramide kinase is crucial for its catalytic activity."
      Kim T.J. , Mitsutake S. , Kato M. , Igarashi Y.
      FEBS Lett.579:4383-4388(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LEU-10
    10. 10.
      "A lipid binding domain in sphingosine kinase 2."
      Don A.S. , Rosen H.
      Biochem. Biophys. Res. Commun.380:87-92(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;ENZYME REGULATION;REGION
    11. 11.
      "Ceramide kinase profiling by mass spectrometry reveals a conserved phosphorylation pattern downstream of the catalytic site."
      Chen W.Q. , Graf C. , Zimmel D. , Rovina P. , Krapfenbauer K. , Jaritz M. , Parker P.J. , Lubec G. , Bornancin F.
      J. Proteome Res.9:420-429(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-340 AND SER-408;MUTAGENESIS OF SER-340
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