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Index > Protein center > CFB(Gene name) > Human
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  • CFB (Gene name),
  • Complement factor B (Protein name ),  CFAB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CFB(BF;BFD);
    Protein name:
    Complement factor B;
    Alternative:
    Glycine-rich beta glycoprotein(GBG);C3/C5 convertase;Properdin factor B;PBF2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    764
    Sequence:
    50:
    MGSNLSPQLC | LMPFILGLLS | GGVTTTPWSL | ARPQGSCSLE | GVEIKGGSFR | 
    100:
    LLQEGQALEY | VCPSGFYPYP | VQTRTCRSTG | SWSTLKTQDQ | KTVRKAECRA | 
    150:
    IHCPRPHDFE | NGEYWPRSPY | YNVSDEISFH | CYDGYTLRGS | ANRTCQVNGR | 
    200:
    WSGQTAICDN | GAGYCSNPGI | PIGTRKVGSQ | YRLEDSVTYH | CSRGLTLRGS | 
    250:
    QRRTCQEGGS | WSGTEPSCQD | SFMYDTPQEV | AEAFLSSLTE | TIEGVDAEDG | 
    300:
    HGPGEQQKRK | IVLDPSGSMN | IYLVLDGSDS | IGASNFTGAK | KCLVNLIEKV | 
    350:
    ASYGVKPRYG | LVTYATYPKI | WVKVSEADSS | NADWVTKQLN | EINYEDHKLK | 
    400:
    SGTNTKKALQ | AVYSMMSWPD | DVPPEGWNRT | RHVIILMTDG | LHNMGGDPIT | 
    450:
    VIDEIRDLLY | IGKDRKNPRE | DYLDVYVFGV | GPLVNQVNIN | ALASKKDNEQ | 
    500:
    HVFKVKDMEN | LEDVFYQMID | ESQSLSLCGM | VWEHRKGTDY | HKQPWQAKIS | 
    550:
    VIRPSKGHES | CMGAVVSEYF | VLTAAHCFTV | DDKEHSIKVS | VGGEKRDLEI | 
    600:
    EVVLFHPNYN | INGKKEAGIP | EFYDYDVALI | KLKNKLKYGQ | TIRPICLPCT | 
    650:
    EGTTRALRLP | PTTTCQQQKE | ELLPAQDIKA | LFVSEEEKKL | TRKEVYIKNG | 
    700:
    DKKGSCERDA | QYAPGYDKVK | DISEVVTPRF | LCTGGVSPYA | DPNTCRGDSG | 
    750:
    GPLIVHKRSR | FIQVGVISWG | VVDVCKNQKR | QKQVPAHARD | FHINLFQVLP | 
    764:
    WLKEKLQDED | LGFL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    MIM:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Complement factor B
    Cat.:
    E2011h
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    Packing:
    96T
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    ELISA Kit for Human Complement factor B
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    E2011p
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    96T
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    ELISA Kit for Human Complement factor B
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    E2011m
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    96T
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    ELISA Kit for Human Complement factor B
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    E2011b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Complement factor B
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    CLIA Kit for Human Complement factor B
    Cat.:
    U2011m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Complement factor B
    Cat.:
    U2011b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Complement factor B
    Cat.:
    U2011h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Complement factor B
    Cat.:
    P2011Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement factor B
    Polyclonal Antibody for Human Complement factor B
    Cat.:
    P2011Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement factor B
    Monoclonal Antibody for Human Complement factor B
    Monoclonal Antibody for Human Complement factor B
    Monoclonal Antibody for Human Complement factor B
    Monoclonal Antibody for Human Complement factor B
    Protein for Human Complement factor B
    Protein for Human Complement factor B
    Protein for Human Complement factor B
    Protein for Human Complement factor B

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular characterization of human complement factor B subtypes."
      Davrinche C. , Abbal M. , Clerc A.
      Immunogenetics32:309-312(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-28; GLN-28; GLN-32 AND SER-736
    2. 2.
      "Human factor B. Complete cDNA sequence of the BF*S allele."
      Mejia J.E. , Jahn I. , de la Salle H. , Hauptmann G.
      Hum. Immunol.39:49-53(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-28 AND GLN-32
      tissue: Liver.
    3. 3.
      "Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase."
      Schwaeble W. , Luettig B. , Sokolowski T. , Estaller C. , Weiss E.H. , Meyer Zum Bueschenfelde K.-H. , Whaley K. , Dippold W.
      Immunobiology188:221-232(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-28 AND GLN-32
      tissue: Liver.
    4. 4.
      "Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression."
      Horiuchi T. , Kim S. , Matsumoto M. , Watanabe I. , Fujita S. , Volanakis J.E.
      Mol. Immunol.30:1587-1592(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-28 AND GLN-32
    5. 5.
      "Expression and alternative splicing of human factor B gene in leukemic mononuclear cells."
      Jaatinen T. , Kanerva J. , Poutanen K.E. , Saarinen-Pihkala U. , Lokki M.-L.
      Submitted (2001-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    6. 6.
      "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T. , Rowen L. , Aguado B. , Ahearn M.E. , Madan A. , Qin S. , Campbell R.D. , Hood L.
      Genome Res.13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      SeattleSNPs variation discovery resource
      Submitted (2002-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-9; GLN-32; TRP-32; SER-252; GLU-565 AND GLU-651
    8. 8.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT TRP-32
    9. 9.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLU-565
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT TRP-32
    11. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT TRP-32
      tissue: Colon.
    12. 12.
      "Complete primary structure for the zymogen of human complement factor B."
      Mole J.E. , Anderson J.K. , Davison E.A. , Woods D.E.
      J. Biol. Chem.259:3407-3412(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-764;PARTIAL NUCLEOTIDE SEQUENCE [MRNA];GLYCOSYLATION AT ASN-122; ASN-142; ASN-285 AND ASN-378
    13. 13.
      "Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major cyanogen bromide-cleavage peptide (CB-II) and completion of the sequence of the Bb fragment."
      Christie D.L. , Gagnon J.
      Biochem. J.209:61-70(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 260-764
    14. 14.
      "Molecular cloning and characterization of the gene coding for human complement protein factor B."
      Campbell R.D. , Porter R.R.
      Proc. Natl. Acad. Sci. U.S.A.80:4464-4468(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 339-764
    15. 15.
      "Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product."
      Woods D.E. , Markham A.F. , Ricker A.T. , Goldberger G. , Colten H.R.
      Proc. Natl. Acad. Sci. U.S.A.79:5661-5665(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 467-595 AND 752-764
    16. 16.
      "Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen."
      Morley B.J. , Campbell R.D.
      EMBO J.3:153-157(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-259
    17. 17.
      "Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements."
      Wu L.C. , Morley B.J. , Campbell R.D.
      Cell48:331-342(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-99
      tissue: Blood.
    18. 18.
      "The principal site of glycation of human complement factor B."
      Niemann M.A. , Bhown A.S. , Miller E.J.
      Biochem. J.274:473-480(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCATION AT LYS-291
    19. 19.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-122; ASN-285 AND ASN-378
      tissue: Plasma.
    20. 20.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-122 AND ASN-285
      tissue: Liver.
    21. 21.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CFBD
    22. 22.
      "New structural motifs on the chymotrypsin fold and their potential roles in complement factor B."
      Jing H. , Xu Y. , Carson M. , Moore D. , Macon K.J. , Volanakis J.E. , Narayana S.V.L.
      EMBO J.19:164-173(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 467-764
    23. 23.
      "Factor B structure provides insights into activation of the central protease of the complement system."
      Milder F.J. , Gomes L. , Schouten A. , Janssen B.J. , Huizinga E.G. , Romijn R.A. , Hemrika W. , Roos A. , Daha M.R. , Gros P.
      Nat. Struct. Mol. Biol.14:224-228(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 26-764;DOMAIN ARCHITECTURE;GLYCOSYLATION AT ASN-122; ASN-142; ASN-285 AND ASN-378
    24. 24.
      "Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex."
      Janssen B.J. , Gomes L. , Koning R.I. , Svergun D.I. , Koster A.J. , Fritzinger D.C. , Vogel C.-W. , Gros P.
      EMBO J.28:2469-2478(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 26-764 IN COMPLEX WITH COBRA VENOM FACTOR;GLYCOSYLATION AT ASN-142 AND ASN-378;DISULFIDE BONDS
    25. 25.
      "Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration."
      Gold B. , Merriam J.E. , Zernant J. , Hancox L.S. , Taiber A.J. , Gehrs K. , Cramer K. , Neel J. , Bergeron J. , Barile G.R. , Smith R.T. , Hageman G.S. , Dean M. , Allikmets R.
      Nat. Genet.38:458-462(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-9 AND GLN-32;INVOLVEMENT IN REDUCED RISK OF ARMD
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS4 LEU-286 AND GLU-323;CHARACTERIZATION OF VARIANTS AHUS4 LEU-286 AND GLU-323
    27. 27.
      "Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."
      Maga T.K. , Nishimura C.J. , Weaver A.E. , Frees K.L. , Smith R.J.H.
      Hum. Mutat.31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS4 PRO-166; GLN-203; LEU-242; GLN-323; ILE-458 AND ARG-533
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