CFB ELISA Kit for Human(Homo sapiens) | EIAab.comCFB ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CFB(Gene name) > Human

CFB (Gene name),

Complement factor B (Protein name ), CFAB_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CFB(BF;BFD);

Protein name:

Complement factor B;

Alternative:

Glycine-rich beta glycoprotein(GBG);C3/C5 convertase;Properdin factor B;PBF2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer.

Function:

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

764

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

764:

WLKEKLQDED | LGFL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P00751

KEGG:

hsa:629

STRING:

9606.ENSP00000388516

MIM:

138470

String:

P00751

Pfam:

PF00084

UniGene:

Hs.69771

Uniprot:

P00751

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ELISA Kit for Human Complement factor B

Cat.:

E2011h

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96T

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ELISA Kit for Human Complement factor B

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E2011p

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96T

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ELISA Kit for Human Complement factor B

Cat.:

E2011m

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96T

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ELISA Kit for Human Complement factor B

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E2011b

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96T

CLIA Kit for Human Complement factor B

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CLIA Kit for Human Complement factor B

Cat.:

U2011m

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96T

CLIA Kit for Human Complement factor B

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U2011b

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96T

CLIA Kit for Human Complement factor B

Cat.:

U2011h

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96T

Polyclonal Antibody for Human Complement factor B

Cat.:

P2011Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Complement factor B

Cat.:

P2011Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Complement factor B

Monoclonal Antibody for Human Complement factor B

Protein for Human Complement factor B

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Molecular characterization of human complement factor B subtypes."
Davrinche C. , Abbal M. , Clerc A.
Immunogenetics32:309-312(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-28; GLN-28; GLN-32 AND SER-736
2.

"Human factor B. Complete cDNA sequence of the BF*S allele."
Mejia J.E. , Jahn I. , de la Salle H. , Hauptmann G.
Hum. Immunol.39:49-53(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-28 AND GLN-32
tissue: Liver.
3.

"Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase."
Schwaeble W. , Luettig B. , Sokolowski T. , Estaller C. , Weiss E.H. , Meyer Zum Bueschenfelde K.-H. , Whaley K. , Dippold W.
Immunobiology188:221-232(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-28 AND GLN-32
tissue: Liver.
4.

"Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression."
Horiuchi T. , Kim S. , Matsumoto M. , Watanabe I. , Fujita S. , Volanakis J.E.
Mol. Immunol.30:1587-1592(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS ARG-28 AND GLN-32
5.

"Expression and alternative splicing of human factor B gene in leukemic mononuclear cells."
Jaatinen T. , Kanerva J. , Poutanen K.E. , Saarinen-Pihkala U. , Lokki M.-L.
Submitted (2001-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
6.

"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T. , Rowen L. , Aguado B. , Ahearn M.E. , Madan A. , Qin S. , Campbell R.D. , Hood L.
Genome Res.13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

SeattleSNPs variation discovery resource
Submitted (2002-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS HIS-9; GLN-32; TRP-32; SER-252; GLU-565 AND GLU-651
8.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT TRP-32
9.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLU-565
10.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT TRP-32
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT TRP-32
tissue: Colon.
12.

"Complete primary structure for the zymogen of human complement factor B."
Mole J.E. , Anderson J.K. , Davison E.A. , Woods D.E.
J. Biol. Chem.259:3407-3412(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 26-764;PARTIAL NUCLEOTIDE SEQUENCE [MRNA];GLYCOSYLATION AT ASN-122; ASN-142; ASN-285 AND ASN-378
13.

"Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major cyanogen bromide-cleavage peptide (CB-II) and completion of the sequence of the Bb fragment."
Christie D.L. , Gagnon J.
Biochem. J.209:61-70(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 260-764
14.

"Molecular cloning and characterization of the gene coding for human complement protein factor B."
Campbell R.D. , Porter R.R.
Proc. Natl. Acad. Sci. U.S.A.80:4464-4468(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 339-764
15.

"Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product."
Woods D.E. , Markham A.F. , Ricker A.T. , Goldberger G. , Colten H.R.
Proc. Natl. Acad. Sci. U.S.A.79:5661-5665(1982) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 467-595 AND 752-764
16.

"Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen."
Morley B.J. , Campbell R.D.
EMBO J.3:153-157(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 16-259
17.

"Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements."
Wu L.C. , Morley B.J. , Campbell R.D.
Cell48:331-342(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-99
tissue: Blood.
18.

"The principal site of glycation of human complement factor B."
Niemann M.A. , Bhown A.S. , Miller E.J.
Biochem. J.274:473-480(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCATION AT LYS-291
19.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-122; ASN-285 AND ASN-378
tissue: Plasma.
20.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-122 AND ASN-285
tissue: Liver.
21.

"Deficiency in complement factor B."
Slade C. , Bosco J. , Unglik G. , Bleasel K. , Nagel M. , Winship I.
N. Engl. J. Med.369:1667-1669(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CFBD
22.

"New structural motifs on the chymotrypsin fold and their potential roles in complement factor B."
Jing H. , Xu Y. , Carson M. , Moore D. , Macon K.J. , Volanakis J.E. , Narayana S.V.L.
EMBO J.19:164-173(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 467-764
23.

"Factor B structure provides insights into activation of the central protease of the complement system."
Milder F.J. , Gomes L. , Schouten A. , Janssen B.J. , Huizinga E.G. , Romijn R.A. , Hemrika W. , Roos A. , Daha M.R. , Gros P.
Nat. Struct. Mol. Biol.14:224-228(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 26-764;DOMAIN ARCHITECTURE;GLYCOSYLATION AT ASN-122; ASN-142; ASN-285 AND ASN-378
24.

"Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex."
Janssen B.J. , Gomes L. , Koning R.I. , Svergun D.I. , Koster A.J. , Fritzinger D.C. , Vogel C.-W. , Gros P.
EMBO J.28:2469-2478(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 26-764 IN COMPLEX WITH COBRA VENOM FACTOR;GLYCOSYLATION AT ASN-142 AND ASN-378;DISULFIDE BONDS
25.

"Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration."
Gold B. , Merriam J.E. , Zernant J. , Hancox L.S. , Taiber A.J. , Gehrs K. , Cramer K. , Neel J. , Bergeron J. , Barile G.R. , Smith R.T. , Hageman G.S. , Dean M. , Allikmets R.
Nat. Genet.38:458-462(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-9 AND GLN-32;INVOLVEMENT IN REDUCED RISK OF ARMD
26.

"Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome."
Goicoechea de Jorge E. , Harris C.L. , Esparza-Gordillo J. , Carreras L. , Arranz E.A. , Garrido C.A. , Lopez-Trascasa M. , Sanchez-Corral P. , Morgan B.P. , Rodriguez de Cordoba S.
Proc. Natl. Acad. Sci. U.S.A.104:240-245(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS4 LEU-286 AND GLU-323;CHARACTERIZATION OF VARIANTS AHUS4 LEU-286 AND GLU-323
27.

"Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome."
Maga T.K. , Nishimura C.J. , Weaver A.E. , Frees K.L. , Smith R.J.H.
Hum. Mutat.31:E1445-E1460(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS AHUS4 PRO-166; GLN-203; LEU-242; GLN-323; ILE-458 AND ARG-533

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