Gene name:
CFLAR (CASH;CASP8AP1;CLARP;MRIT) ;
Protein name:
CASP8 and FADD-like apoptosis regulator ;
Alternative:
Caspase-eight-related protein (Casper) ;Caspase homolog (CASH) ;Cellular FLICE-like inhibitory protein (c-FLIP) ;Caspase-like apoptosis regulatory protein (CLARP) ;Inhibitor of FLICE (I-FLICE) ;FADD-like antiapoptotic molecule 1 (FLAME-1) ;Usurpin ;MACH-related inducer of toxicity (MRIT) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X.
Function:
Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
Subcellular Location:
N/A
Protein Attributes:
50:
MSAEVIHQVE | EALDTDEKEM | LLFLCRDVAI | DVVPPNVRDL | LDILRERGKL |
100:
SVGDLAELLY | RVRRFDLLKR | ILKMDRKAVE | THLLRNPHLV | SDYRVLMAEI |
150:
GEDLDKSDVS | SLIFLMKDYM | GRGKISKEKS | FLDLVVELEK | LNLVAPDQLD |
200:
LLEKCLKNIH | RIDLKTKIQK | YKQSVQGAGT | SYRNVLQAAI | QKSLKDPSNN |
250:
FRLHNGRSKE | QRLKEQLGAQ | QEPVKKSIQE | SEAFLPQSIP | EERYKMKSKP |
300:
LGICLIIDCI | GNETELLRDT | FTSLGYEVQK | FLHLSMHGIS | QILGQFACMP |
350:
EHRDYDSFVC | VLVSRGGSQS | VYGVDQTHSG | LPLHHIRRMF | MGDSCPYLAG |
400:
KPKMFFIQNY | VVSEGQLEDS | SLLEVDGPAM | KNVEFKAQKR | GLCTVHREAD |
450:
FFWSLCTADM | SLLEQSHSSP | SLYLQCLSQK | LRQERKRPLL | DLHIELNGYM |
480:
YDWNSRVSAK | EKYYVWLQHT | LRKKLILSYT |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human CASP8 and FADD-like apoptosis regulator
ELISA Kit for Human CASP8 and FADD-like apoptosis regulator
CLIA Kit for Human CASP8 and FADD-like apoptosis regulator
CLIA Kit for Human CASP8 and FADD-like apoptosis regulator
Polyclonal Antibody for Human CASP8 and FADD-like apoptosis regulator
Polyclonal Antibody for Human CASP8 and FADD-like apoptosis regulator
Monoclonal Antibody for Human CASP8 and FADD-like apoptosis regulator
Monoclonal Antibody for Human CASP8 and FADD-like apoptosis regulator
Protein for Human CASP8 and FADD-like apoptosis regulator
Protein for Human CASP8 and FADD-like apoptosis regulator
R&D Technical Data
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Precision
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Recovery
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Linearity
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Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Lymph .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)