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Index > Protein center > CFLAR(Gene name) > Human
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  • CFLAR (Gene name),
  • CASP8 and FADD-like apoptosis regulator (Protein name ),  CFLAR_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CFLAR(CASH;CASP8AP1;CLARP;MRIT);
    Protein name:
    CASP8 and FADD-like apoptosis regulator;
    Alternative:
    Caspase-eight-related protein(Casper);Caspase homolog(CASH);Cellular FLICE-like inhibitory protein(c-FLIP);Caspase-like apoptosis regulatory protein(CLARP);Inhibitor of FLICE(I-FLICE);FADD-like antiapoptotic molecule 1(FLAME-1);Usurpin;MACH-related inducer of toxicity(MRIT);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X.
    Function:
    Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    480
    Sequence:
    50:
    MSAEVIHQVE | EALDTDEKEM | LLFLCRDVAI | DVVPPNVRDL | LDILRERGKL | 
    100:
    SVGDLAELLY | RVRRFDLLKR | ILKMDRKAVE | THLLRNPHLV | SDYRVLMAEI | 
    150:
    GEDLDKSDVS | SLIFLMKDYM | GRGKISKEKS | FLDLVVELEK | LNLVAPDQLD | 
    200:
    LLEKCLKNIH | RIDLKTKIQK | YKQSVQGAGT | SYRNVLQAAI | QKSLKDPSNN | 
    250:
    FRLHNGRSKE | QRLKEQLGAQ | QEPVKKSIQE | SEAFLPQSIP | EERYKMKSKP | 
    300:
    LGICLIIDCI | GNETELLRDT | FTSLGYEVQK | FLHLSMHGIS | QILGQFACMP | 
    350:
    EHRDYDSFVC | VLVSRGGSQS | VYGVDQTHSG | LPLHHIRRMF | MGDSCPYLAG | 
    400:
    KPKMFFIQNY | VVSEGQLEDS | SLLEVDGPAM | KNVEFKAQKR | GLCTVHREAD | 
    450:
    FFWSLCTADM | SLLEQSHSSP | SLYLQCLSQK | LRQERKRPLL | DLHIELNGYM | 
    480:
    YDWNSRVSAK | EKYYVWLQHT | LRKKLILSYT | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    KEGG:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human CASP8 and FADD-like apoptosis regulator
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    E15094h
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    ELISA Kit for Human CASP8 and FADD-like apoptosis regulator
    Cat.:
    E15094m
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    Packing:
    96T
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    CLIA Kit for Human CASP8 and FADD-like apoptosis regulator
    MSDS:
    Please sign in first.
    CLIA Kit for Human CASP8 and FADD-like apoptosis regulator
    Cat.:
    U15094h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human CASP8 and FADD-like apoptosis regulator
    Polyclonal Antibody for Human CASP8 and FADD-like apoptosis regulator
    Monoclonal Antibody for Human CASP8 and FADD-like apoptosis regulator
    Monoclonal Antibody for Human CASP8 and FADD-like apoptosis regulator
    Protein for Human CASP8 and FADD-like apoptosis regulator
    Protein for Human CASP8 and FADD-like apoptosis regulator

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Casper is a FADD- and caspase-related inducer of apoptosis."
      Shu H.-B. , Halpin D.R. , Goeddel D.V.
      Immunity6:751-763(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 13 AND 14);MUTAGENESIS OF TYR-360
      tissue: Embryonic kidney.
      tissue: Umbilical vein endothelial cell.
    2. 2.
      "MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death."
      Han D.K.M. , Chaudhary P.M. , Wright M.E. , Friedman C. , Trask B.J. , Riedel R.T. , Baskin D.G. , Schwartz S.M. , Hood L.
      Proc. Natl. Acad. Sci. U.S.A.94:11333-11338(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Peripheral blood lymphocyte.
    4. 4.
      "FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis."
      Srinivasula S.M. , Ahmad M. , Ottilie S. , Bullrich F. , Banks S. , Wang Y. , Fernandes-Alnemri T. , Croce C.M. , Litwack G. , Tomaselli K.J. , Armstrong R.C. , Alnemri E.S.
      J. Biol. Chem.272:18542-18545(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 8; 9 AND 10);MUTAGENESIS OF ASP-376
      tissue: T-cell.
    5. 5.
      "I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1- and CD-95-induced apoptosis."
      Hu S. , Vincenz C. , Ni J. , Gentz R. , Dixit V.M.
      J. Biol. Chem.272:17255-17257(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Umbilical vein endothelial cell.
    6. 6.
      Hu S. , Dixit V.M.
      Submitted (1998-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4; 5; 6 AND 7)
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Skin fibroblast.
    8. 8.
      "CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis."
      Inohara N. , Koseki T. , Hu Y. , Chen S. , Nunez G.
      Proc. Natl. Acad. Sci. U.S.A.94:10717-10722(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
      tissue: Colon carcinoma.
    9. 9.
      "Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex."
      Rasper D.M. , Vaillancourt J.P. , Hadano S. , Houtzager V.M. , Seiden I. , Keen S.L.C. , Tawa P. , Xanthoudakis S. , Nasir J. , Martindale D. , Koop B.F. , Peterson E.P. , Thornberry N.A. , Huang J. , MacPherson D.P. , Black S.C. , Hornung F. , Lenardo M.J. , more...
      Cell Death Differ.5:271-288(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 11 AND 12)
      tissue: Kidney.
    10. 10.
      "Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2."
      Hadano S. , Yanagisawa Y. , Skaug J. , Fichter K. , Nasir J. , Martindale D. , Koop B.F. , Scherer S.W. , Nicholson D.W. , Rouleau G.A. , Ikeda J.-E. , Hayden M.R.
      Genomics71:200-213(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    11. 11.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    12. 12.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 15)
      tissue: Cerebellum.
      tissue: Corpus callosum.
      tissue: Subthalamic nucleus.
    13. 13.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    15. 15.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Lymph.
    16. 16.
      "The role of c-FLIP in modulation of CD95-induced apoptosis."
      Scaffidi C. , Schmitz I. , Krammer P.H. , Peter M.E.
      J. Biol. Chem.274:1541-1548(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis."
      Algeciras-Schimnich A. , Griffith T.S. , Lynch D.H. , Paya C.V.
      J. Immunol.162:5205-5211(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    18. 18.
      "Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal."
      Kim K.H. , Seong B.L.
      EMBO J.22:2104-2116(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HBV PROTEIN X
    19. 19.
      "An unappreciated role for RNA surveillance."
      Hillman R.T. , Green R.E. , Brenner S.E.
      Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
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