CIRBP ELISA Kit for Human(Homo sapiens) | EIAab.comCIRBP ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CIRBP(Gene name) > Human

CIRBP (Gene name),

Cold-inducible RNA-binding protein (Protein name ), CIRBP_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CIRBP(A18HNRNP;CIRP);

Protein name:

Cold-inducible RNA-binding protein;

Alternative:

Glycine-rich RNA-binding protein CIRP;A18 hnRNP;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with EIF4G1. Associates with ribosomes.

Function:

Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity). Promotes assembly of stress granules (SGs), when overexpressed.

Subcellular Location:

Nucleus nucleoplasm Cytoplasm Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins.

Protein Attributes:

Sequence length:

172

Sequence:

50:

100:

150:

172:

YSDRSSGGSY | RDSYDSYATH | NE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q14011

UniGene:

Hs.618145

MIM:

602649

STRING:

9606.ENSP00000322887

KEGG:

hsa:1153

Pfam:

PF00076

String:

Q14011

Uniprot:

Q14011

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ELISA Kit for Human Cold-inducible RNA-binding protein

Cat.:

E12931r

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96T

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ELISA Kit for Human Cold-inducible RNA-binding protein

Cat.:

E12931m

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96T

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ELISA Kit for Human Cold-inducible RNA-binding protein

Cat.:

E12931h

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96T

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CLIA Kit for Human Cold-inducible RNA-binding protein

Cat.:

U12931m

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Packing:

96T

CLIA Kit for Human Cold-inducible RNA-binding protein

Cat.:

U12931h

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Packing:

96T

CLIA Kit for Human Cold-inducible RNA-binding protein

Cat.:

U12931r

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Packing:

96T

Polyclonal Antibody for Human Cold-inducible RNA-binding protein

Cat.:

P12931Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Cold-inducible RNA-binding protein

Protein for Human Cold-inducible RNA-binding protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene."
Nishiyama H. , Higashitsuji H. , Yokoi H. , Itoh K. , Danno S. , Matsuda T. , Fujita J.
Gene204:115-120(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein."
Sheikh M.S. , Carrier F. , Papathanasiou M.A. , Hollander M.C. , Zhan Q. , Yu K. , Fornace A.J. Jr.
J. Biol. Chem.272:26720-26726(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
tissue: Brain.
tissue: Uterus.
4.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
tissue: Placenta.
6.

"The UV-inducible RNA-binding protein A18 (A18 hnRNP) plays a protective role in the genotoxic stress response."
Yang C. , Carrier F.
J. Biol. Chem.276:47277-47284(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;RNA-BINDING;SUBCELLULAR LOCATION
7.

"Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism."
Wellmann S. , Buehrer C. , Moderegger E. , Zelmer A. , Kirschner R. , Koehne P. , Fujita J. , Seeger K.
J. Cell Sci.117:1785-1794(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION BY HYPOXIA
8.

"Post-transcriptional regulation of thioredoxin by the stress inducible heterogeneous ribonucleoprotein A18."
Yang R. , Weber D.J. , Carrier F.
Nucleic Acids Res.34:1224-1236(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;RNA-BINDING;INTERACTION WITH EIF4G1;ASSOCIATION WITH RIBOSOMES
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
12.

"Solution structure of RRM domain in A18 HNRNP."
RIKEN structural genomics initiative (RSGI)
Submitted (2005-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-90

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