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Index > Protein center > CLEC4E(Gene name) > Human
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  • CLEC4E (Gene name),
  • C-type lectin domain family 4 member E (Protein name ),  CLC4E_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    CLEC4E(UNQ218/PRO244;CLECSF9;MINCLE);
    Protein name:
    C-type lectin domain family 4 member E;
    Alternative:
    Macrophage-inducible C-type lectin;C-type lectin superfamily member 9;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer. Homodimer.
    Function:
    C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B.
    Subcellular Location:
    Membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    219
    Sequence:
    50:
    MNSSKSSETQ | CTERGCFSSQ | MFLWTVAGIP | ILFLSACFIT | RCVVTFRIFQ | 
    100:
    TCDEKKFQLP | ENFTELSCYN | YGSGSVKNCC | PLNWEYFQSS | CYFFSTDTIS | 
    150:
    WALSLKNCSA | MGAHLVVINS | QEEQEFLSYK | KPKMREFFIG | LSDQVVEGQW | 
    200:
    QWVDGTPLTK | SLSFWDVGEP | NNIATLEDCA | TMRDSSNPRQ | NWNDVTCFLN | 
    219:
    YFRICEMVGI | NPLNKGKSL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    MIM:
    String:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human C-type lectin domain family 4 member E
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    E1596h
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    ELISA Kit for Human C-type lectin domain family 4 member E
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    E1596m
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    Packing:
    96T
    ELISA Kit for Human C-type lectin domain family 4 member E
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    E1596r
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    Packing:
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    CLIA Kit for Human C-type lectin domain family 4 member E
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    U1596r
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    Packing:
    96T
    CLIA Kit for Human C-type lectin domain family 4 member E
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    U1596m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human C-type lectin domain family 4 member E
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    U1596h
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    Polyclonal Antibody for Human C-type lectin domain family 4 member E
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    P1596Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human C-type lectin domain family 4 member E
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    P1596Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human C-type lectin domain family 4 member E
    Cat.:
    P1596Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human C-type lectin domain family 4 member E
    Monoclonal Antibody for Human C-type lectin domain family 4 member E
    Monoclonal Antibody for Human C-type lectin domain family 4 member E
    Protein for Human C-type lectin domain family 4 member E
    Protein for Human C-type lectin domain family 4 member E
    Protein for Human C-type lectin domain family 4 member E

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages."
      Matsumoto M. , Shimada T. , Kaisho T. , Sanjo H. , Tanaka T. , Copeland N.G. , Gilbert D.J. , Jenkins N.A. , Akira S.
      J. Immunol.163:5039-5048(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Monocytic leukemia.
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Kidney.
    7. 7.
      "Human and mouse macrophage-inducible C-type lectin (Mincle) bind Candida albicans."
      Bugarcic A. , Hitchens K. , Beckhouse A.G. , Wells C.A. , Ashman R.B. , Blanchard H.
      Glycobiology18:679-685(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS RECEPTOR FOR CANDIDA ALBICANS;SUBUNIT
    8. 8.
      "Mincle is an ITAM-coupled activating receptor that senses damaged cells."
      Yamasaki S. , Ishikawa E. , Sakuma M. , Hara H. , Ogata K. , Saito T.
      Nat. Immunol.9:1179-1188(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FCER1G
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