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Index > Protein center > Lta(Gene name) > Mouse
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  • Lta (Gene name),
  • Lymphotoxin-alpha (Protein name ),  TNFB_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Lta(Tnfb;Tnfsf1);
    Protein name:
    Lymphotoxin-alpha(LT-alpha);
    Alternative:
    TNF-beta;Tumor necrosis factor ligand superfamily member 1;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homotrimer, and heterotrimer of either two LTB and one LTA subunits or (less prevalent) two LTA and one LTB subunits.
    Function:
    Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
    Subcellular Location:
    Secreted Membrane The homotrimer is secreted (By similarity). The heterotrimer is membrane-associated.
    Protein Attributes:
    Sequence length:
    202
    Sequence:
    50:
    MTLLGRLHLL | RVLGTPPVFL | LGLLLALPLG | AQGLSGVRFS | AARTAHPLPQ | 
    100:
    KHLTHGILKP | AAHLVGYPSK | QNSLLWRAST | DRAFLRHGFS | LSNNSLLIPT | 
    150:
    SGLYFVYSQV | VFSGESCSPR | AIPTPIYLAH | EVQLFSSQYP | FHVPLLSAQK | 
    200:
    SVYPGLQGPW | VRSMYQGAVF | LLSKGDQLST | HTDGISHLHF | SPSSVFFGAF | 
    202:
    AL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    KEGG:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse LT-alpha
    Cat.:
    E0134h
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    96T
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    ELISA Kit for Mouse LT-alpha
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    E0134m
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    96T
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    ELISA Kit for Mouse LT-alpha
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    E0134p
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    ELISA Kit for Mouse LT-alpha
    Cat.:
    E0134b
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    ELISA Kit for Mouse LT-alpha
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    E0134r
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    ELISA Kit for Mouse LT-alpha
    MSDS:
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    ELISA Kit for Mouse LT-alpha
    Cat.:
    E0134d
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    Packing:
    96T
    CLIA Kit for Mouse LT-alpha
    MSDS:
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    CLIA Kit for Mouse LT-alpha
    Cat.:
    U0134r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse LT-alpha
    Cat.:
    U0134d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Mouse LT-alpha
    Cat.:
    U0134b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Mouse LT-alpha
    Cat.:
    U0134p
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse LT-alpha
    Cat.:
    U0134m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse LT-alpha
    Cat.:
    U0134h
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    Please sign in first.
    MSDS:
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    Packing:
    96T
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    Polyclonal Antibody for Mouse LT-alpha
    Polyclonal Antibody for Mouse LT-alpha
    Polyclonal Antibody for Mouse LT-alpha
    Cat.:
    P0134Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse LT-alpha
    Polyclonal Antibody for Mouse LT-alpha
    Cat.:
    P0134Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse LT-alpha
    Polyclonal Antibody for Mouse LT-alpha
    Cat.:
    P0134Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse LT-alpha
    Monoclonal Antibody for Mouse LT-alpha
    Monoclonal Antibody for Mouse LT-alpha
    Monoclonal Antibody for Mouse LT-alpha
    Monoclonal Antibody for Mouse LT-alpha
    Monoclonal Antibody for Mouse LT-alpha
    Monoclonal Antibody for Mouse LT-alpha
    Protein for Mouse LT-alpha
    Protein for Mouse LT-alpha
    Protein for Mouse LT-alpha
    Protein for Mouse LT-alpha
    Protein for Mouse LT-alpha
    Protein for Mouse LT-alpha
    Protein for Mouse LT-alpha

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    References
    1. 1.
      "Nucleotide sequence of the murine TNF locus, including the TNF-alpha (tumor necrosis factor) and TNF-beta (lymphotoxin) genes."
      Semon D. , Kawashima E. , Jongeneel C.V. , Shakhov A.N. , Nedospasov S.A.
      Nucleic Acids Res.15:9083-9084(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "The genes for tumor necrosis factor (TNF-alpha) and lymphotoxin (TNF-beta) are tandemly arranged on chromosome 17 of the mouse."
      Nedospasov S.A. , Hirt B. , Shakhov A.N. , Dobrynin V.N. , Kawashima E. , Accolla R.S. , Jongeneel C.V.
      Nucleic Acids Res.14:7713-7725(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "The murine tumor necrosis factor-beta (lymphotoxin) gene sequence."
      Gray P.W. , Chen E. , Tang W.-L. , Ruddle N.H.
      Nucleic Acids Res.15:3937-3937(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Cloning and expression of murine lymphotoxin cDNA."
      Li C.B. , Gray P.W. , Lin P.F. , McGrath K.M. , Ruddle F.H. , Ruddle N.H.
      J. Immunol.138:4496-4501(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "Mouse lymphotoxin and tumor necrosis factor: structural analysis of the cloned genes, physical linkage, and chromosomal position."
      Gardner S.M. , Mock B.A. , Hilgers J. , Huppi K.E. , Roeder W.D.
      J. Immunol.139:476-483(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    6. 6.
      "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T. , Rowen L. , Aguado B. , Ahearn M.E. , Madan A. , Qin S. , Campbell R.D. , Hood L.
      Genome Res.13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: 129.
    7. 7.
      "Induction of tumor necrosis factor-alpha and -beta and interferon-gamma mRNA by interleukin 2 in murine lymphocytic cell lines."
      Weil D. , Dautry F.
      Oncogene Res.3:409-414(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 6-202
    8. 8.
      "RNA processing is a limiting step for murine tumor necrosis factor beta expression in response to interleukin-2."
      Weil D. , Brosset S. , Dautry F.
      Mol. Cell. Biol.10:5865-5875(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 56-76
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