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Index > Protein center > UBA3(Gene name) > Human
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  • UBA3 (Gene name),
  • NEDD8-activating enzyme E1 catalytic subunit (Protein name ),  UBA3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    UBA3(UBE1C);
    Protein name:
    NEDD8-activating enzyme E1 catalytic subunit;
    Alternative:
    Ubiquitin-activating enzyme E1C;NEDD8-activating enzyme E1C;Ubiquitin-like modifier-activating enzyme 3(Ubiquitin-activating enzyme 3);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer of UBA3 and NAE1. Interacts with NEDD8, UBE2F and UBE2M. Binds ESR1 and ESR2 with bound steroid ligand.
    Function:
    Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Down-regulates steroid receptor activity. Necessary for cell cycle progression.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    463
    Sequence:
    50:
    MADGEEPEKK | RRRIEELLAE | KMAVDGGCGD | TGDWEGRWNH | VKKFLERSGP | 
    100:
    FTHPDFEPST | ESLQFLLDTC | KVLVIGAGGL | GCELLKNLAL | SGFRQIHVID | 
    150:
    MDTIDVSNLN | RQFLFRPKDI | GRPKAEVAAE | FLNDRVPNCN | VVPHFNKIQD | 
    200:
    FNDTFYRQFH | IIVCGLDSII | ARRWINGMLI | SLLNYEDGVL | DPSSIVPLID | 
    250:
    GGTEGFKGNA | RVILPGMTAC | IECTLELYPP | QVNFPMCTIA | SMPRLPEHCI | 
    300:
    EYVRMLQWPK | EQPFGEGVPL | DGDDPEHIQW | IFQKSLERAS | QYNIRGVTYR | 
    350:
    LTQGVVKRII | PAVASTNAVI | AAVCATEVFK | IATSAYIPLN | NYLVFNDVDG | 
    400:
    LYTYTFEAER | KENCPACSQL | PQNIQFSPSA | KLQEVLDYLT | NSASLQMKSP | 
    450:
    AITATLEGKN | RTLYLQSVTS | IEERTRPNLS | KTLKELGLVD | GQELAVADVT | 
    463:
    TPQTVLFKLH | FTS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    KEGG:
    MIM:
    Pfam:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    E1027h
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    96T
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    ELISA Kit for Human NEDD8-activating enzyme E1 catalytic subunit
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    E1027m
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    Packing:
    96T
    ELISA Kit for Human NEDD8-activating enzyme E1 catalytic subunit
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    E1027r
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    Packing:
    96T
    CLIA Kit for Human NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    U1027r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    U1027h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    U1027m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    P1027Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    P1027Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human NEDD8-activating enzyme E1 catalytic subunit
    Cat.:
    P1027Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human NEDD8-activating enzyme E1 catalytic subunit
    Monoclonal Antibody for Human NEDD8-activating enzyme E1 catalytic subunit
    Monoclonal Antibody for Human NEDD8-activating enzyme E1 catalytic subunit
    Protein for Human NEDD8-activating enzyme E1 catalytic subunit
    Protein for Human NEDD8-activating enzyme E1 catalytic subunit
    Protein for Human NEDD8-activating enzyme E1 catalytic subunit

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Fetal kidney.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
    3. 3.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ARG-9
      tissue: Prostatic adenocarcinoma.
    6. 6.
      "Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway."
      Gong L. , Yeh E.T.H.
      J. Biol. Chem.274:12036-12042(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-463 (ISOFORM 1);VARIANT ARG-9;FUNCTION;MUTAGENESIS OF CYS-237;TISSUE SPECIFICITY
      tissue: Placenta.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-463;FUNCTION
    8. 8.
      "Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer."
      Bohnsack R.N. , Haas A.L.
      J. Biol. Chem.278:26823-26830(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH NAE1
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    11. 11.
      "The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1."
      Walden H. , Podgorski M.S. , Huang D.T. , Miller D.W. , Howard R.J. , Minor D.L. Jr. , Holton J.M. , Schulman B.A.
      Mol. Cell12:1427-1437(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 33-463 IN COMPLEX WITH NAE1; NEDD8 AND ATP;MUTAGENESIS OF ARG-211
    12. 12.
      "Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8."
      Walden H. , Podgorski M.S. , Schulman B.A.
      Nature422:330-334(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 24-463 IN COMPLEX WITH NAE1;MUTAGENESIS OF ILE-148; ASP-167; 227-LEU-TYR-228; THR-238; ILE-310 AND 352-TYR--TYR-357
    13. 13.
      "A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8."
      Huang D.T. , Miller D.W. , Mathew R. , Cassell R. , Holton J.M. , Roussel M.F. , Schulman B.A.
      Nat. Struct. Mol. Biol.11:927-935(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 33-463 IN COMPLEX WITH NAE1 AND UBE2M;MUTAGENESIS OF PHE-65; 160-HIS-ILE-161; PRO-192; ILE-195; PRO-197; LEU-214; MET-217 AND ILE-331
    14. 14.
      "Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1."
      Huang D.T. , Paydar A. , Zhuang M. , Waddell M.B. , Holton J.M. , Schulman B.A.
      Mol. Cell17:341-350(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 368-463 IN COMPLEX WITH UBE2M;MUTAGENESIS OF SER-368; GLN-369; LEU-370; THR-412; LEU-415; VAL-418; ILE-421 AND ARG-424
    15. 15.
      "E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification."
      Huang D.T. , Ayrault O. , Hunt H.W. , Taherbhoy A.M. , Duda D.M. , Scott D.C. , Borg L.A. , Neale G. , Murray P.J. , Roussel M.F. , Schulman B.A.
      Mol. Cell33:483-495(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 368-420 IN COMPLEX WITH UBE2F
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