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Index > Protein center > UBE2A(Gene name) > Human
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  • UBE2A (Gene name),
  • Ubiquitin-conjugating enzyme E2 A (Protein name ),  UBE2A_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    UBE2A(RAD6A);
    Protein name:
    Ubiquitin-conjugating enzyme E2 A;
    Alternative:
    Ubiquitin carrier protein A;RAD6 homolog A(HR6A;hHR6A);Ubiquitin-protein ligase A;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with RAD18 and WAC.
    Function:
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    152
    Sequence:
    50:
    MSTPARRRLM | RDFKRLQEDP | PAGVSGAPSE | NNIMVWNAVI | FGPEGTPFED | 
    100:
    GTFKLTIEFT | EEYPNKPPTV | RFVSKMFHPN | VYADGSICLD | ILQNRWSPTY | 
    150:
    DVSSILTSIQ | SLLDEPNPNS | PANSQAAQLY | QENKREYEKR | VSAIVEQSWR | 
    152:
    DC
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    UniGene:
    MIM:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 A
    Cat.:
    E0991h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Ubiquitin-conjugating enzyme E2 A
    Cat.:
    E0991m
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 A
    Cat.:
    U0991h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Ubiquitin-conjugating enzyme E2 A
    Cat.:
    U0991m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 A
    Cat.:
    P0991Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ubiquitin-conjugating enzyme E2 A
    Cat.:
    P0991Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 A
    Monoclonal Antibody for Human Ubiquitin-conjugating enzyme E2 A
    Protein for Human Ubiquitin-conjugating enzyme E2 A
    Protein for Human Ubiquitin-conjugating enzyme E2 A

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    References
    1. 1.
      "Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6."
      Koken M.H.M. , Reynolds P. , Jaspers-Dekker I. , Prakash L. , Prakash S. , Bootsma D. , Hoeijmakers J.H.J.
      Proc. Natl. Acad. Sci. U.S.A.88:8865-8869(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Subthalamic nucleus.
    3. 3.
      NIEHS SNPs program
      Submitted (2005-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Skin.
    7. 7.
      "The human homolog of yeast BRE1 functions as a transcriptional coactivator through direct activator interactions."
      Kim J. , Hake S.B. , Roeder R.G.
      Mol. Cell20:759-770(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "UBE2A, which encodes a ubiquitin-conjugating enzyme, is mutated in a novel X-linked mental retardation syndrome."
      Nascimento R.M. , Otto P.A. , de Brouwer A.P. , Vianna-Morgante A.M.
      Am. J. Hum. Genet.79:549-555(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MRXSN
    9. 9.
      "The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines."
      David Y. , Ziv T. , Admon A. , Navon A.
      J. Biol. Chem.285:8595-8604(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "WAC, a functional partner of RNF20/40, regulates histone H2B ubiquitination and gene transcription."
      Zhang F. , Yu X.
      Mol. Cell41:384-397(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WAC
    12. 12.
      "Phosphorylation by cyclin-dependent kinase-9 controls ubiquitin-conjugating enzyme-2A function."
      Shchebet A. , Karpiuk O. , Kremmer E. , Eick D. , Johnsen S.A.
      Cell Cycle11:2122-2127(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-120
    13. 13.
      "Novel missense mutations in the ubiquitination-related gene UBE2A cause a recognizable X-linked mental retardation syndrome."
      Budny B. , Badura-Stronka M. , Materna-Kiryluk A. , Tzschach A. , Raynaud M. , Latos-Bielenska A. , Ropers H.H.
      Clin. Genet.77:541-551(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MRXSN GLN-11 AND ARG-23
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