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Index > Protein center > Ube2b(Gene name) > Rat
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  • Ube2b (Gene name),
  • Ubiquitin-conjugating enzyme E2 B (Protein name ),  UBE2B_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Ube2b(Rad6b);
    Protein name:
    Ubiquitin-conjugating enzyme E2 B;
    Alternative:
    Ubiquitin carrier protein B;RAD6 homolog B(HR6B);Ubiquitin-protein ligase B;Ubiquitin-conjugating enzyme E2(14k);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with RAD18, UBR2 and WAC.
    Function:
    Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation (By similarity). In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. May be involved in neurite outgrowth.
    Subcellular Location:
    Cell membrane Nucleus In peripheral neurons, expressed both at the plasma membrane and in nuclei.
    Protein Attributes:
    Sequence length:
    152
    Sequence:
    50:
    MSTPARRRLM | RDFKRLQEDP | PVGVSGAPSE | NNIMQWNAVI | FGPEGTPFED | 
    100:
    GTFKLVIEFS | EEYPNKPPTV | RFLSKMFHPN | VYADGSICLD | ILQNRWSPTY | 
    150:
    DVSSILTSIQ | SLLDEPNPNS | PANSQAAQLY | QENKREYEKR | VSAIVEQSWN | 
    152:
    DS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    KEGG:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Ubiquitin-conjugating enzyme E2 B
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    E1063h
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    ELISA Kit for Rat Ubiquitin-conjugating enzyme E2 B
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    E1063r
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    ELISA Kit for Rat Ubiquitin-conjugating enzyme E2 B
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    E1063b
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    ELISA Kit for Rat Ubiquitin-conjugating enzyme E2 B
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    E1063m
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    ELISA Kit for Rat Ubiquitin-conjugating enzyme E2 B
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    CLIA Kit for Rat Ubiquitin-conjugating enzyme E2 B
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    U1063r
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    96T
    CLIA Kit for Rat Ubiquitin-conjugating enzyme E2 B
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    U1063b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Ubiquitin-conjugating enzyme E2 B
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    U1063h
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    96T
    CLIA Kit for Rat Ubiquitin-conjugating enzyme E2 B
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    U1063m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Ubiquitin-conjugating enzyme E2 B
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    Polyclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
    Cat.:
    P1063Rb-m
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    40ug/0.2ml
    Polyclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
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    P1063Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
    Polyclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
    Cat.:
    P1063Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
    Monoclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
    Monoclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
    Monoclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
    Monoclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
    Monoclonal Antibody for Rat Ubiquitin-conjugating enzyme E2 B
    Protein for Rat Ubiquitin-conjugating enzyme E2 B
    Protein for Rat Ubiquitin-conjugating enzyme E2 B
    Protein for Rat Ubiquitin-conjugating enzyme E2 B
    Protein for Rat Ubiquitin-conjugating enzyme E2 B
    Protein for Rat Ubiquitin-conjugating enzyme E2 B

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A rabbit reticulocyte ubiquitin carrier protein that supports ubiquitin-dependent proteolysis (E214k) is homologous to the yeast DNA repair gene RAD6."
      Wing S.S. , Dumas F. , Banville D.
      J. Biol. Chem.267:6495-6501(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
    2. 2.
      "14-kDa ubiquitin-conjugating enzyme: structure of the rat gene and regulation upon fasting and by insulin."
      Wing S.S. , Banville D.
      Am. J. Physiol.267:E39-E48(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA];TISSUE SPECIFICITY
    3. 3.
      "Isolation of a ubiquitin-conjugating enzyme gene induced following cerebral ischemia from the rat brain using modified subtractive hybridization and differential screening."
      Chen D. , Graham S.H. , Jing K. , Simon R.P. , Chen J.
      Submitted (1999-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE
      tissue: Brain.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Heart.
    5. 5.
      "The N-end rule ubiquitin-conjugating enzyme, HR6B, is up-regulated by nerve growth factor and required for neurite outgrowth."
      Kavakebi P. , Hausott B. , Tomasino A. , Ingorokva S. , Klimaschewski L.
      Mol. Cell. Neurosci.29:559-568(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;SUBCELLULAR LOCATION;FUNCTION
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