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Index > Protein center > UBQLN2(Gene name) > Human
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  • UBQLN2 (Gene name),
  • Ubiquilin-2 (Protein name ),  UBQL2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    UBQLN2(HRIHFB2157;N4BP4;PLIC2);
    Protein name:
    Ubiquilin-2;
    Alternative:
    DSK2 homolog;Chap1;Ubiquitin-like product Chap1/Dsk2;Protein linking IAP with cytoskeleton 2(PLIC-2;hPLIC-2);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds UBE3A and BTRC. Interacts with the 19S proteasome subunit.
    Function:
    Increases the half-life of proteins destined to be degraded by the proteasome; may modulate proteasome-mediated protein degradation.
    Subcellular Location:
    Cytoplasm Nucleus Where it colocalizes with the proteasome. Associated with fibers in mitotic cells.
    Protein Attributes:
    Sequence length:
    624
    Sequence:
    50:
    MAENGESSGP | PRPSRGPAAA | QGSAAAPAEP | KIIKVTVKTP | KEKEEFAVPE | 
    100:
    NSSVQQFKEA | ISKRFKSQTD | QLVLIFAGKI | LKDQDTLIQH | GIHDGLTVHL | 
    150:
    VIKSQNRPQG | QSTQPSNAAG | TNTTSASTPR | SNSTPISTNS | NPFGLGSLGG | 
    200:
    LAGLSSLGLS | STNFSELQSQ | MQQQLMASPE | MMIQIMENPF | VQSMLSNPDL | 
    250:
    MRQLIMANPQ | MQQLIQRNPE | ISHLLNNPDI | MRQTLEIARN | PAMMQEMMRN | 
    300:
    QDLALSNLES | IPGGYNALRR | MYTDIQEPML | NAAQEQFGGN | PFASVGSSSS | 
    350:
    SGEGTQPSRT | ENRDPLPNPW | APPPATQSSA | TTSTTTSTGS | GSGNSSSNAT | 
    400:
    GNTVAAANYV | ASIFSTPGMQ | SLLQQITENP | QLIQNMLSAP | YMRSMMQSLS | 
    450:
    QNPDLAAQMM | LNSPLFTANP | QLQEQMRPQL | PAFLQQMQNP | DTLSAMSNPR | 
    500:
    AMQALMQIQQ | GLQTLATEAP | GLIPSFTPGV | GVGVLGTAIG | PVGPVTPIGP | 
    550:
    IGPIVPFTPI | GPIGPIGPTG | PAAPPGSTGS | GGPTGPTVSS | AAPSETTSPT | 
    600:
    SESGPNQQFI | QQMVQALAGA | NAPQLPNPEV | RFQQQLEQLN | AMGFLNREAN | 
    624:
    LQALIATGGD | INAAIERLLG | SQPS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    KEGG:
    MIM:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Ubiquilin-2
    Cat.:
    E0508h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Ubiquilin-2
    Cat.:
    E0508m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Ubiquilin-2
    Cat.:
    U0508h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Ubiquilin-2
    Cat.:
    U0508m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Ubiquilin-2
    Cat.:
    P0508Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Ubiquilin-2
    Cat.:
    P0508Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Ubiquilin-2
    Monoclonal Antibody for Human Ubiquilin-2
    Protein for Human Ubiquilin-2
    Protein for Human Ubiquilin-2

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch."
      Kaye F.J. , Modi S. , Ivanovska I. , Koonin E.V. , Thress K. , Kubo A. , Kornbluth S. , Rose M.D.
      FEBS Lett.467:348-355(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH STCH
      tissue: Lung.
    2. 2.
      "The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome."
      Kleijnen M.F. , Shih A.H. , Zhou P. , Kumar S. , Soccio R.E. , Kedersha N.L. , Gill G. , Howley P.M.
      Mol. Cell6:409-419(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH THE PROTEASOME AND UBE3A
      tissue: B-cell.
    3. 3.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 37-624
      tissue: Amygdala.
    7. 7.
      "Selection system for genes encoding nuclear-targeted proteins."
      Ueki N. , Oda T. , Kondo M. , Yano K. , Noguchi T. , Muramatsu M.-A.
      Nat. Biotechnol.16:1338-1342(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 217-624;SUBCELLULAR LOCATION
      tissue: Fetal brain.
    8. 8.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking."
      Farg M.A. , Sundaramoorthy V. , Sultana J.M. , Yang S. , Atkinson R.A. , Levina V. , Halloran M.A. , Gleeson P.A. , Blair I.P. , Soo K.Y. , King A.E. , Atkin J.D.
      Hum. Mol. Genet.23:3579-3595(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C9ORF72
    12. 12.
      "Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a."
      Walters K.J. , Kleijnen M.F. , Goh A.M. , Wagner G. , Howley P.M.
      Biochemistry41:1767-1777(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-103
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALS15 HIS-497; SER-497; THR-506; SER-509 AND SER-525;CHARACTERIZATION OF VARIANTS ALS15 HIS-497 AND THR-506
    14. 14.
      "Screening in ALS and FTD patients reveals 3 novel UBQLN2 mutations outside the PXX domain and a pure FTD phenotype."
      Synofzik M. , Maetzler W. , Grehl T. , Prudlo J. , Vom Hagen J.M. , Haack T. , Rebassoo P. , Munz M. , Schols L. , Biskup S.
      Neurobiol. Aging33:E13-E17(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALS15 THR-283 AND ARG-425;VARIANT VAL-282
    15. 15.
      "UBQLN2/ubiquilin 2 mutation and pathology in familial amyotrophic lateral sclerosis."
      Williams K.L. , Warraich S.T. , Yang S. , Solski J.A. , Fernando R. , Rouleau G.A. , Nicholson G.A. , Blair I.P.
      Neurobiol. Aging33:E3-E10(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALS15 ILE-487
    16. 16.
      "UBQLN2 mutations are rare in French and French-Canadian amyotrophic lateral sclerosis."
      Daoud H. , Suhail H. , Szuto A. , Camu W. , Salachas F. , Meininger V. , Bouchard J.P. , Dupre N. , Dion P.A. , Rouleau G.A.
      Neurobiol. Aging33:E1-E5(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALS15 ASN-155 AND THR-189
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