Protein name:
Complement C3 ;
Alternative:
HSE-MSF ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
C3dg interacts with CR2 (via the N-terminal Sushi domains 1 and 2). Interacts with VSIG4 (By similarity). C3 precursor is first processed by the removal of 4 Arg residues, forming two chains, beta and alpha, linked by a disulfide bond. C3 convertase activates C3 by cleaving the alpha chain, releasing C3a anaphylatoxin and generating C3b (beta chain + alpha' chain).
Function:
Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. The short isoform has B-cell stimulatory activity.
Subcellular Location:
Secreted
Protein Attributes:
50:
MGPASGSQLL | VLLLLLASSP | LALGIPMYSI | ITPNVLRLES | EETIVLEAHD |
100:
AQGDIPVTVT | VQDFLKRQVL | TSEKTVLTGA | SGHLRSVSIK | IPASKEFNSD |
150:
KEGHKYVTVV | ANFGETVVEK | AVMVSFQSGY | LFIQTDKTIY | TPGSTVLYRI |
200:
FTVDNNLLPV | GKTVVILIET | PDGIPVKRDI | LSSNNQHGIL | PLSWNIPELV |
250:
NMGQWKIRAF | YEHAPKQIFS | AEFEVKEYVL | PSFEVRVEPT | ETFYYIDDPN |
300:
GLEVSIIAKF | LYGKNVDGTA | FVIFGVQDGD | KKISLAHSLT | RVVIEDGVGD |
350:
AVLTRKVLME | GVRPSNADAL | VGKSLYVSVT | VILHSGSDMV | EAERSGIPIV |
400:
TSPYQIHFTK | TPKFFKPAMP | FDLMVFVTNP | DGSPASKVLV | VTQGSNAKAL |
450:
TQDDGVAKLS | INTPNSRQPL | TITVRTKKDT | LPESRQATKT | MEAHPYSTMH |
500:
NSNNYLHLSV | SRMELKPGDN | LNVNFHLRTD | PGHEAKIRYY | TYLVMNKGKL |
550:
LKAGRQVREP | GQDLVVLSLP | ITPEFIPSFR | LVAYYTLIGA | SGQREVVADS |
600:
VWVDVKDSCI | GTLVVKGDPR | DNHLAPGQQT | TLRIEGNQGA | RVGLVAVDKG |
650:
VFVLNKKNKL | TQSKIWDVVE | KADIGCTPGS | GKNYAGVFMD | AGLAFKTSQG |
700:
LQTEQRADLE | CTKPAARRRR | SVQLMERRMD | KAGQYTDKGL | RKCCEDGMRD |
750:
IPMRYSCQRR | ARLITQGENC | IKAFIDCCNH | ITKLREQHRR | DHVLGLARSE |
800:
LEEDIIPEED | IISRSHFPQS | WLWTIEELKE | PEKNGISTKV | MNIFLKDSIT |
850:
TWEILAVSLS | DKKGICVADP | YEIRVMQDFF | IDLRLPYSVV | RNEQVEIRAV |
900:
LFNYREQEEL | KVRVELLHNP | AFCSMATAKN | RYFQTIKIPP | KSSVAVPYVI |
950:
VPLKIGQQEV | EVKAAVFNHF | ISDGVKKTLK | VVPEGMRINK | TVAIHTLDPE |
1000:
KLGQGGVQKV | DVPAADLSDQ | VPDTDSETRI | ILQGSPVVQM | AEDAVDGERL |
1050:
KHLIVTPAGC | GEQNMIGMTP | TVIAVHYLDQ | TEQWEKFGIE | KRQEALELIK |
1100:
KGYTQQLAFK | QPSSAYAAFN | NRPPSTWLTA | YVVKVFSLAA | NLIAIDSHVL |
1150:
CGAVKWLILE | KQKPDGVFQE | DGPVIHQEMI | GGFRNAKEAD | VSLTAFVLIA |
1200:
LQEARDICEG | QVNSLPGSIN | KAGEYIEASY | MNLQRPYTVA | IAGYALALMN |
1250:
KLEEPYLGKF | LNTAKDRNRW | EEPDQQLYNV | EATSYALLAL | LLLKDFDSVP |
1300:
PVVRWLNEQR | YYGGGYGSTQ | ATFMVFQALA | QYQTDVPDHK | DLNMDVSFHL |
1350:
PSRSSATTFR | LLWENGNLLR | SEETKQNEAF | SLTAKGKGRG | TLSVVAVYHA |
1400:
KLKSKVTCKK | FDLRVSIRPA | PETAKKPEEA | KNTMFLEICT | KYLGDVDATM |
1450:
SILDISMMTG | FAPDTKDLEL | LASGVDRYIS | KYEMNKAFSN | KNTLIIYLEK |
1500:
ISHTEEDCLT | FKVHQYFNVG | LIQPGSVKVY | SYYNLEESCT | RFYHPEKDDG |
1550:
MLSKLCHSEM | CRCAEENCFM | QQSQEKINLN | VRLDKACEPG | VDYVYKTELT |
1600:
NIELLDDFDE | YTMTIQQVIK | SGSDEVQAGQ | QRKFISHIKC | RNALKLQKGK |
1650:
KYLMWGLSSD | LWGEKPNTSY | IIGKDTWVEH | WPEAEECQDQ | KYQKQCEELG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Pig
Rat
Bovine
Rabbit
ELISA Kit for Mouse Complement C3
ELISA Kit for Mouse Complement C3
ELISA Kit for Mouse Complement C3
ELISA Kit for Mouse Complement C3
ELISA Kit for Mouse Complement C3
ELISA Kit for Mouse Complement C3
CLIA Kit for Mouse Complement C3
CLIA Kit for Mouse Complement C3
CLIA Kit for Mouse Complement C3
CLIA Kit for Mouse Complement C3
CLIA Kit for Mouse Complement C3
CLIA Kit for Mouse Complement C3
Polyclonal Antibody for Mouse Complement C3
Polyclonal Antibody for Mouse Complement C3
Polyclonal Antibody for Mouse Complement C3
Polyclonal Antibody for Mouse Complement C3
Polyclonal Antibody for Mouse Complement C3
Polyclonal Antibody for Mouse Complement C3
Monoclonal Antibody for Mouse Complement C3
Monoclonal Antibody for Mouse Complement C3
Monoclonal Antibody for Mouse Complement C3
Monoclonal Antibody for Mouse Complement C3
Monoclonal Antibody for Mouse Complement C3
Monoclonal Antibody for Mouse Complement C3
Protein for Mouse Complement C3
Protein for Mouse Complement C3
Protein for Mouse Complement C3
Protein for Mouse Complement C3
Protein for Mouse Complement C3
Protein for Mouse Complement C3
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
J Meng, Y Ji, J Liu, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Liver .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-724 (ISOFORM LONG)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-34
5.
"Common evolutionary origin of alpha 2-macroglobulin and complement components C3 and C4."
Sottrup-Jensen L.
,
Stepanik T.M.
,
Kristensen T.
,
Lonblad P.B.
,
Jones C.M.
,
Wierzbicki D.M.
,
Magnusson S.
,
Domdey H.
,
Wetsel R.A.
,
Lundwall A.
,
Tack B.F.
,
Fey G.H.
Proc. Natl. Acad. Sci. U.S.A.82:9-13(1985)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 25-1663 (ISOFORM LONG)
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 25-240 (ISOFORM LONG)
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 25-41 AND 749-760
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 25-31 AND 671-680
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 658-761
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 671-1663 (ISOFORM LONG)
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 671-748
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE INITIATION (ISOFORM SHORT)
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE;FUNCTION