COL4A1 ELISA Kit for Human(Homo sapiens) | EIAab.comCOL4A1 ELISA Kit for Human(Homo sapiens)

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COL4A1 (Gene name),

Collagen alpha-1(IV) chain (Protein name ), CO4A1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

COL4A1;

Protein name:

Collagen alpha-1(IV) chain;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

There are six type IV collagen isoforms, alpha 1(IV)-alpha 6(IV), each of which can form a triple helix structure with 2 other chains to generate type IV collagen network.

Function:

Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin.

Subcellular Location:

Secreted extracellular space extracellular matrix basement membrane

Protein Attributes:

Sequence length:

1669

Sequence:

50:

100:

150:

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250:

300:

350:

400:

450:

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550:

600:

650:

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750:

800:

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1150:

1200:

1250:

1300:

1350:

1400:

1450:

1500:

1550:

1600:

1650:

1669:

KAGELRTHVS | RCQVCMRRT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.17441

KEGG:

hsa:1282

SMR:

P02462

MIM:

120130

STRING:

9606.ENSP00000364979

Pfam:

PF01413

String:

P02462

Uniprot:

P02462

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ELISA Kit for Human Collagen alpha-1(IV) chain

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E0180h

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96T

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ELISA Kit for Human Collagen alpha-1(IV) chain

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E0180m

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96T

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ELISA Kit for Human Collagen alpha-1(IV) chain

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E0180r

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96T

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ELISA Kit for Human Collagen alpha-1(IV) chain

Cat.:

E0180b

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96T

CLIA Kit for Human Collagen alpha-1(IV) chain

Cat.:

U0180m

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96T

CLIA Kit for Human Collagen alpha-1(IV) chain

Cat.:

U0180b

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96T

CLIA Kit for Human Collagen alpha-1(IV) chain

Cat.:

U0180h

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human Collagen alpha-1(IV) chain

Cat.:

U0180r

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96T

Polyclonal Antibody for Human Collagen alpha-1(IV) chain

Cat.:

P0180Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Collagen alpha-1(IV) chain

Cat.:

P0180Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Collagen alpha-1(IV) chain

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P0180Rb-r

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Polyclonal Antibody for Human Collagen alpha-1(IV) chain

Monoclonal Antibody for Human Collagen alpha-1(IV) chain

Protein for Human Collagen alpha-1(IV) chain

Cat.:

R0180h

Price:

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Packing:

1mg

Purity:

>90%

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Structural organization of the gene for the alpha 1 chain of human type IV collagen."
Soininen R. , Huotari M. , Ganguly A. , Prockop D.J. , Tryggvason K.
J. Biol. Chem.264:13565-13571(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PRO-555
2.

"The DNA sequence and analysis of human chromosome 13."
Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS PRO-555 AND HIS-1334
tissue: Brain.
4.

"Completion of the amino acid sequence of the alpha 1 chain of human basement membrane collagen (type IV) reveals 21 non-triplet interruptions located within the collagenous domain."
Brazel D. , Oberbaeumer I. , Dieringer H. , Babel W. , Glanville R.W. , Deutzmann R. , Kuehn K.
Eur. J. Biochem.168:529-536(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-943;VARIANT PRO-555
tissue: Placenta.
5.

"The structural genes for alpha 1 and alpha 2 chains of human type IV collagen are divergently encoded on opposite DNA strands and have an overlapping promoter region."
Soininen R. , Huotari M. , Hostikka S.L. , Prockop D.J. , Tryggvason K.
J. Biol. Chem.263:17217-17220(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-28
6.

"Amino acid sequence of the N-terminal aggregation and cross-linking region (7S domain) of the alpha 1 (IV) chain of human basement membrane collagen."
Glanville R.W. , Qian R.Q. , Siebold B. , Risteli J. , Kuehn K.
Eur. J. Biochem.152:213-219(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 28-243
7.

"Complete primary structure of the alpha 1-chain of human basement membrane (type IV) collagen."
Soininen R. , Haka-Risku T. , Prockop D.J. , Tryggvason K.
FEBS Lett.225:188-194(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-1257;VARIANT PRO-555
tissue: Placenta.
8.

"Structure of human-basement-membrane (type IV) collagen. Complete amino-acid sequence of a 914-residue-long pepsin fragment from the alpha 1(IV) chain."
Babel W. , Glanville R.W.
Eur. J. Biochem.143:545-556(1984) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 534-1447
9.

"cDNA clones coding for the pro-alpha1(IV) chain of human type IV procollagen reveal an unusual homology of amino acid sequences in two halves of the carboxyl-terminal domain."
Pihlajaniemi T. , Tryggvason K. , Myers J.C. , Kurkinen M. , Lebo R. , Cheung M.-C. , Prockop D.J. , Boyd C.D.
J. Biol. Chem.260:7681-7687(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1256-1669
10.

"Restricted homology between human alpha 1 type IV and other procollagen chains."
Brinker J.M. , Gudas L.J. , Loidl H.R. , Wang S.-Y. , Rosenbloom J. , Kefalides N.A. , Myers J.C.
Proc. Natl. Acad. Sci. U.S.A.82:3649-3653(1985) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1259-1669
11.

"The arrangement of intra- and intermolecular disulfide bonds in the carboxyterminal, non-collagenous aggregation and cross-linking domain of basement-membrane type IV collagen."
Siebold B. , Deutzmann R. , Kuehn K.
Eur. J. Biochem.176:617-624(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 1441-1669;DISULFIDE BONDS
tissue: Placenta.
12.

"Anti-angiogenic cues from vascular basement membrane collagen."
Colorado P.C. , Torre A. , Kamphaus G. , Maeshima Y. , Hopfer H. , Takahashi K. , Volk R. , Zamborsky E.D. , Herman S. , Sarkar P.K. , Ericksen M.B. , Dhanabal M. , Simons M. , Post M. , Kufe D.W. , Weichselbaum R.R. , Sukhatme V.P. , Kalluri R.
Cancer Res.60:2520-2526(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1441-1669;FUNCTION OF ARRESTEN;TISSUE SPECIFICITY
13.

"Arresten, a collagen-derived inhibitor of angiogenesis."
Fu J. , Bai X. , Wang W. , Ruan C.
Submitted (2001-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1441-1669
14.

Peng X. , Yin B. , Yuan J. , Qiang B.
Submitted (2001-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1441-1669
15.

"Molecular cloning and sequencing of human arresten gene."
Zheng Q.C. , Song Z.F. , Zheng Y.W. , Li Y.Q. , Shu X.
Zhonghua Shi Yan Wai Ke Za Zhi19:46-47(2002)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1441-1669
16.

"Cloning and expression of arresten in Escherichia coli and Pachia pastoris."
He A.B.
Submitted (2002-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1441-1669
17.

"Construction of recombinant plasmid and prokaryotic expression in E. coli and biological activity analysis of human placenta arresten gene."
Zheng J.P. , Tang H.Y. , Chen X.J. , Yu B.F. , Xie J. , Wu T.C.
Hepatobiliary Pancreat. Dis. Int.5:74-79(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1441-1669;FUNCTION;TISSUE SPECIFICITY
tissue: Placenta.
18.

"Human alpha1 type IV collagen NC1 domain exhibits distinct antiangiogenic activity mediated by alpha1beta1 integrin."
Sudhakar A. , Nyberg P. , Keshamouni V.G. , Mannam A.P. , Li J. , Sugimoto H. , Cosgrove D. , Kalluri R.
J. Clin. Invest.115:2801-2810(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF RECEPTOR;FUNCTION OF ARRESTEN
19.

"Characterization of the anti-angiogenic properties of arresten, an alpha1beta1 integrin-dependent collagen-derived tumor suppressor."
Nyberg P. , Xie L. , Sugimoto H. , Colorado P. , Sund M. , Holthaus K. , Sudhakar A. , Salo T. , Kalluri R.
Exp. Cell Res.314:3292-3305(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF RECEPTOR;FUNCTION OF ARRESTEN
20.

"The 1.9-A crystal structure of the noncollagenous (NC1) domain of human placenta collagen IV shows stabilization via a novel type of covalent Met-Lys cross-link."
Than M.E. , Henrich S. , Huber R. , Ries A. , Mann K. , Kuhn K. , Timpl R. , Bourenkov G.P. , Bartunik H.D. , Bode W.
Proc. Natl. Acad. Sci. U.S.A.99:6607-6612(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1441-1669;ADDITIONAL INTERCHAIN LINKS
21.

"Mutations in Col4a1 cause perinatal cerebral hemorrhage and porencephaly."
Gould D.B. , Phalan F.C. , Breedveld G.J. , van Mil S.E. , Smith R.S. , Schimenti J.C. , Aguglia U. , van der Knaap M.S. , Heutink P. , John S.W.M.
Science308:1167-1171(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS POREN1 SER-749 AND ARG-1236
22.

"Novel mutations in three families confirm a major role of COL4A1 in hereditary porencephaly."
Breedveld G. , de Coo I.F. , Lequin M.H. , Arts W.F.M. , Heutink P. , Gould D.B. , John S.W.M. , Oostra B. , Mancini G.M.S.
J. Med. Genet.43:490-495(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS POREN1 ASP-1130 AND ARG-1423
23.

"Role of COL4A1 in small-vessel disease and hemorrhagic stroke."
Gould D.B. , Phalan F.C. , van Mil S.E. , Sundberg J.P. , Vahedi K. , Massin P. , Bousser M.G. , Heutink P. , Miner J.H. , Tournier-Lasserve E. , John S.W.M.
N. Engl. J. Med.354:1489-1496(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSVDH GLU-562
24.

"COL4A1 mutation in Axenfeld-Rieger anomaly with leukoencephalopathy and stroke."
Sibon I. , Coupry I. , Menegon P. , Bouchet J.P. , Gorry P. , Burgelin I. , Calvas P. , Orignac I. , Dousset V. , Lacombe D. , Orgogozo J.M. , Arveiler B. , Goizet C.
Ann. Neurol.62:177-184(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSVDH ASP-720
25.

"COL4A1 mutations and hereditary angiopathy, nephropathy, aneurysms, and muscle cramps."
Plaisier E. , Gribouval O. , Alamowitch S. , Mougenot B. , Prost C. , Verpont M.C. , Marro B. , Desmettre T. , Cohen S.Y. , Roullet E. , Dracon M. , Fardeau M. , Van Agtmael T. , Kerjaschki D. , Antignac C. , Ronco P.
N. Engl. J. Med.357:2687-2695(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HANAC VAL-498; ARG-519 AND GLU-528
26.

"A sulfilimine bond identified in collagen IV."
Vanacore R. , Ham A.-J.L. , Voehler M. , Sanders C.R. , Conrads T.P. , Veenstra T.D. , Sharpless K.B. , Dawson P.E. , Hudson B.G.
Science325:1230-1234(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERCHAIN SULFILIMINE BONDS
27.

"COL4A1 mutation in a patient with sporadic, recurrent intracerebral hemorrhage."
Vahedi K. , Kubis N. , Boukobza M. , Arnoult M. , Massin P. , Tournier-Lasserve E. , Bousser M.G.
Stroke38:1461-1464(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSVDH ARG-805
28.

"COL4A1 mutation in two preterm siblings with antenatal onset of parenchymal hemorrhage."
de Vries L.S. , Koopman C. , Groenendaal F. , Van Schooneveld M. , Verheijen F.W. , Verbeek E. , Witkamp T.D. , van der Worp H.B. , Mancini G.
Ann. Neurol.65:12-18(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT POREN1 ARG-1580
29.

"Novel COL4A1 mutations associated with HANAC syndrome: a role for the triple helical CB3[IV] domain."
Plaisier E. , Chen Z. , Gekeler F. , Benhassine S. , Dahan K. , Marro B. , Alamowitch S. , Paques M. , Ronco P.
Am. J. Med. Genet. A152:2550-2555(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HANAC ARG-498; ARG-510 AND LEU-525
30.

"Ophthalmological features associated with COL4A1 mutations."
Coupry I. , Sibon I. , Mortemousque B. , Rouanet F. , Mine M. , Goizet C.
Arch. Ophthalmol.128:483-489(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BSVDH ASP-720 AND ARG-755
31.

"A dominantly inherited mutation in collagen IV A1 (COL4A1) causing childhood onset stroke without porencephaly."
Shah S. , Kumar Y. , McLean B. , Churchill A. , Stoodley N. , Rankin J. , Rizzu P. , van der Knaap M. , Jardine P.
Eur. J. Paediatr. Neurol.14:182-187(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSVDH ARG-755
32.

"Sequence variants in COL4A1 and COL4A2 genes in Ecuadorian families with keratoconus."
Karolak J.A. , Kulinska K. , Nowak D.M. , Pitarque J.A. , Molinari A. , Rydzanicz M. , Bejjani B.A. , Gajecka M.
Mol. Vis.17:827-843(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-7; PRO-555 AND HIS-1334

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