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Index > Protein center > C8B(Gene name) > Human
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  • C8B (Gene name),
  • Complement component C8 beta chain (Protein name ),  CO8B_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    C8B;
    Protein name:
    Complement component C8 beta chain;
    Alternative:
    Complement component 8 subunit beta;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.
    Function:
    Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    591
    Sequence:
    50:
    MKNSRTWAWR | APVELFLLCA | ALGCLSLPGS | RGERPHSFGS | NAVNKSFAKS | 
    100:
    RQMRSVDVTL | MPIDCELSSW | SSWTTCDPCQ | KKRYRYAYLL | QPSQFHGEPC | 
    150:
    NFSDKEVEDC | VTNRPCRSQV | RCEGFVCAQT | GRCVNRRLLC | NGDNDCGDQS | 
    200:
    DEANCRRIYK | KCQHEMDQYW | GIGSLASGIN | LFTNSFEGPV | LDHRYYAGGC | 
    250:
    SPHYILNTRF | RKPYNVESYT | PQTQGKYEFI | LKEYESYSDF | ERNVTEKMAS | 
    300:
    KSGFSFGFKI | PGIFELGISS | QSDRGKHYIR | RTKRFSHTKS | VFLHARSDLE | 
    350:
    VAHYKLKPRS | LMLHYEFLQR | VKRLPLEYSY | GEYRDLFRDF | GTHYITEAVL | 
    400:
    GGIYEYTLVM | NKEAMERGDY | TLNNVHACAK | NDFKIGGAIE | EVYVSLGVSV | 
    450:
    GKCRGILNEI | KDRNKRDTMV | EDLVVLVRGG | ASEHITTLAY | QELPTADLMQ | 
    500:
    EWGDAVQYNP | AIIKVKVEPL | YELVTATDFA | YSSTVRQNMK | QALEEFQKEV | 
    550:
    SSCHCAPCQG | NGVPVLKGSR | CDCICPVGSQ | GLACEVSYRK | NTPIDGKWNC | 
    591:
    WSNWSSCSGR | RKTRQRQCNN | PPPQNGGSPC | SGPASETLDC | S
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    MIM:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Complement component C8 beta chain
    Cat.:
    E9155m
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Complement component C8 beta chain
    Cat.:
    E9155r
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Complement component C8 beta chain
    Cat.:
    E9155h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human Complement component C8 beta chain
    MSDS:
    Please sign in first.
    CLIA Kit for Human Complement component C8 beta chain
    MSDS:
    Please sign in first.
    CLIA Kit for Human Complement component C8 beta chain
    Cat.:
    U9155r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Complement component C8 beta chain
    Cat.:
    U9155m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Complement component C8 beta chain
    Cat.:
    U9155h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Complement component C8 beta chain
    Cat.:
    P9155Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement component C8 beta chain
    Polyclonal Antibody for Human Complement component C8 beta chain
    Cat.:
    P9155Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Complement component C8 beta chain
    Monoclonal Antibody for Human Complement component C8 beta chain
    Monoclonal Antibody for Human Complement component C8 beta chain
    Monoclonal Antibody for Human Complement component C8 beta chain
    Monoclonal Antibody for Human Complement component C8 beta chain
    Protein for Human Complement component C8 beta chain
    Protein for Human Complement component C8 beta chain
    Protein for Human Complement component C8 beta chain
    Protein for Human Complement component C8 beta chain

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complementary DNA and derived amino acid sequence of the beta subunit of human complement protein C8: identification of a close structural and ancestral relationship to the alpha subunit and C9."
      Howard O.M.Z. , Rao A.G. , Sodetz J.M.
      Biochemistry26:3565-3570(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;GLYCOSYLATION
      tissue: Liver.
    2. 2.
      Sodetz J.M.
      Submitted (1988-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Liver.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLY-117
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    7. 7.
      "Complementary DNA cloning of complement C8 beta and its sequence homology to C9."
      Haefliger J.-A. , Tschopp J. , Nardelli D. , Wahli W. , Kocher H.-P. , Tosi M. , Stanley K.K.
      Biochemistry26:3551-3556(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 47-591;PROTEIN SEQUENCE OF 55-68
      tissue: Liver.
    8. 8.
      "The eighth component of human complement. Purification and physicochemical characterization of its unusual subunit structure."
      Steckel E.W. , York R.G. , Monahan J.B. , Sodetz J.M.
      J. Biol. Chem.255:11997-12005(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;CHARACTERIZATION;SUBUNIT
    9. 9.
      "The four terminal components of the complement system are C-mannosylated on multiple tryptophan residues."
      Hofsteenge J. , Blommers M. , Hess D. , Furmanek A. , Miroshnichenko O.
      J. Biol. Chem.274:32786-32794(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT TRP-70; TRP-73; TRP-551 AND TRP-554
    10. 10.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-243
      tissue: Plasma.
    11. 11.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-243
      tissue: Liver.
    12. 12.
      "Structure of human C8 protein provides mechanistic insight into membrane pore formation by complement."
      Lovelace L.L. , Cooper C.L. , Sodetz J.M. , Lebioda L.
      J. Biol. Chem.286:17585-17592(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 55-591;PHOSPHORYLATION AT THR-418;SUBUNIT;DISULFIDE BONDS
    13. 13.
      "Human complement component C8. Molecular basis of the beta-chain polymorphism."
      Dewald G. , Hemmer S. , Noethen M.M.
      FEBS Lett.340:211-215(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLY-117;DEFINITION OF ALLOTYPES C8B A AND C8B B
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