Protein name:
Complement component C8 beta chain ;
Alternative:
Complement component 8 subunit beta ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterotrimer of 3 chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded. Component of the membrane attack complex (MAC). MAC assembly is initiated by protelytic cleavage of C5 into C5a and C5b. C5b binds sequentially C6, C7, C8 and multiple copies of the pore-forming subunit C9.
Function:
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.
Subcellular Location:
Secreted
Protein Attributes:
50:
MKNSRTWAWR | APVELFLLCA | ALGCLSLPGS | RGERPHSFGS | NAVNKSFAKS |
100:
RQMRSVDVTL | MPIDCELSSW | SSWTTCDPCQ | KKRYRYAYLL | QPSQFHGEPC |
150:
NFSDKEVEDC | VTNRPCRSQV | RCEGFVCAQT | GRCVNRRLLC | NGDNDCGDQS |
200:
DEANCRRIYK | KCQHEMDQYW | GIGSLASGIN | LFTNSFEGPV | LDHRYYAGGC |
250:
SPHYILNTRF | RKPYNVESYT | PQTQGKYEFI | LKEYESYSDF | ERNVTEKMAS |
300:
KSGFSFGFKI | PGIFELGISS | QSDRGKHYIR | RTKRFSHTKS | VFLHARSDLE |
350:
VAHYKLKPRS | LMLHYEFLQR | VKRLPLEYSY | GEYRDLFRDF | GTHYITEAVL |
400:
GGIYEYTLVM | NKEAMERGDY | TLNNVHACAK | NDFKIGGAIE | EVYVSLGVSV |
450:
GKCRGILNEI | KDRNKRDTMV | EDLVVLVRGG | ASEHITTLAY | QELPTADLMQ |
500:
EWGDAVQYNP | AIIKVKVEPL | YELVTATDFA | YSSTVRQNMK | QALEEFQKEV |
550:
SSCHCAPCQG | NGVPVLKGSR | CDCICPVGSQ | GLACEVSYRK | NTPIDGKWNC |
591:
WSNWSSCSGR | RKTRQRQCNN | PPPQNGGSPC | SGPASETLDC | S
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
Rabbit
ELISA Kit for Human Complement component C8 beta chain
ELISA Kit for Human Complement component C8 beta chain
ELISA Kit for Human Complement component C8 beta chain
ELISA Kit for Human Complement component C8 beta chain
CLIA Kit for Human Complement component C8 beta chain
CLIA Kit for Human Complement component C8 beta chain
CLIA Kit for Human Complement component C8 beta chain
CLIA Kit for Human Complement component C8 beta chain
Polyclonal Antibody for Human Complement component C8 beta chain
Polyclonal Antibody for Human Complement component C8 beta chain
Polyclonal Antibody for Human Complement component C8 beta chain
Polyclonal Antibody for Human Complement component C8 beta chain
Monoclonal Antibody for Human Complement component C8 beta chain
Monoclonal Antibody for Human Complement component C8 beta chain
Monoclonal Antibody for Human Complement component C8 beta chain
Monoclonal Antibody for Human Complement component C8 beta chain
Protein for Human Complement component C8 beta chain
Protein for Human Complement component C8 beta chain
Protein for Human Complement component C8 beta chain
Protein for Human Complement component C8 beta chain
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE;GLYCOSYLATION
tissue :
Liver .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Liver .
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"The DNA sequence and biological annotation of human chromosome 1."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLY-117
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 47-591;PROTEIN SEQUENCE OF 55-68
tissue :
Liver .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PARTIAL PROTEIN SEQUENCE;CHARACTERIZATION;SUBUNIT
9.
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Cited for : GLYCOSYLATION AT TRP-70; TRP-73; TRP-551 AND TRP-554
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-243
tissue :
Plasma .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-243
tissue :
Liver .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.51 ANGSTROMS) OF 55-591;PHOSPHORYLATION AT THR-418;SUBUNIT;DISULFIDE BONDS
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT GLY-117;DEFINITION OF ALLOTYPES C8B A AND C8B B