Protein name:
Cofilin-1 ;
Alternative:
Cofilin, non-muscle isoform ;18 kDa phosphoprotein (p18) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods.
Function:
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis.
Subcellular Location:
Nucleus matrix
Cytoplasm
cytoskeleton
Cell projection
ruffle membrane
Peripheral membrane protein
Cytoplasmic side
Cell projection
lamellipodium membrane
Peripheral membrane protein
Cytoplasmic side
Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.
Protein Attributes:
50:
MASGVAVSDG | VIKVFNDMKV | RKSSTPEEVK | KRKKAVLFCL | SEDKKNIILE |
100:
EGKEILVGDV | GQTVDDPYAT | FVKMLPDKDC | RYALYDATYE | TKESKKEDLV |
150:
FIFWAPESAP | LKSKMIYASS | KDAIKKKLTG | IKHELQANCY | EEVKDRCTLA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Pig
Bovine
ELISA Kit for Human Cofilin-1
ELISA Kit for Human Cofilin-1
ELISA Kit for Human Cofilin-1
ELISA Kit for Human Cofilin-1
ELISA Kit for Human Cofilin-1
CLIA Kit for Human Cofilin-1
CLIA Kit for Human Cofilin-1
CLIA Kit for Human Cofilin-1
CLIA Kit for Human Cofilin-1
CLIA Kit for Human Cofilin-1
Polyclonal Antibody for Human Cofilin-1
Polyclonal Antibody for Human Cofilin-1
Polyclonal Antibody for Human Cofilin-1
Polyclonal Antibody for Human Cofilin-1
Polyclonal Antibody for Human Cofilin-1
Monoclonal Antibody for Human Cofilin-1
Monoclonal Antibody for Human Cofilin-1
Monoclonal Antibody for Human Cofilin-1
Monoclonal Antibody for Human Cofilin-1
Monoclonal Antibody for Human Cofilin-1
Protein for Human Cofilin-1
Protein for Human Cofilin-1
Protein for Human Cofilin-1
Protein for Human Cofilin-1
Protein for Human Cofilin-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Placenta .
2.
"A provisional transcript map of the spinal muscular atrophy (SMA) critical region."
van der Steege G.
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Pre-B cell .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
4.
"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N.
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Chen X.
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Rolfs A.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
5.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .
6.
Mural R.J.
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Istrail S.
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Sutton G.G.
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Florea L.
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Halpern A.L.
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Myers E.W.
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Lung .
tissue :
Ovary .
tissue :
Placenta .
tissue :
Uterus .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-21
tissue :
Platelet .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-13 AND 54-73;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
B-cell lymphoma .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 34-45; 54-73; 82-92; 96-112; 133-146 AND 153-166;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Brain .
tissue :
Cajal-Retzius cell .
tissue :
Fetal brain cortex .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 52-71
tissue :
Platelet .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-3 BY NRK
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-140;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;DEPHOSPHORYLATION BY PDXP
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION;IDENTIFICATION BY MASS SPECTROMETRY
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3 AND SER-156;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-68 AND SER-156;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2; LYS-13; LYS-73 AND LYS-144;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3; THR-25 AND SER-156;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
23.
"Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
Bai S.W.
,
Herrera-Abreu M.T.
,
Rohn J.L.
,
Racine V.
,
Tajadura V.
,
Suryavanshi N.
,
Bechtel S.
,
Wiemann S.
,
Baum B.
,
Ridley A.J.
BMC Biol.9:54-54(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
26.
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Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
28.
"Beta-arrestin-dependent activation of the cofilin pathway is required for the scavenging activity of the atypical chemokine receptor D6."
Borroni E.M.
,
Cancellieri C.
,
Vacchini A.
,
Benureau Y.
,
Lagane B.
,
Bachelerie F.
,
Arenzana-Seisdedos F.
,
Mizuno K.
,
Mantovani A.
,
Bonecchi R.
,
Locati M.
Sci. Signal.6:RA30-RA30(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : FUNCTION;PHOSPHORYLATION
29.
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Cited for : STRUCTURE BY NMR