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Index > Protein center > Cfl1(Gene name) > Mouse
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  • Cfl1 (Gene name),
  • Cofilin-1 (Protein name ),  COF1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Cfl1;
    Protein name:
    Cofilin-1;
    Alternative:
    Cofilin, non-muscle isoform;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods.
    Function:
    Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis.
    Subcellular Location:
    Nucleus matrix Cytoplasm cytoskeleton Cell projection ruffle membrane Peripheral membrane protein Cytoplasmic side Cell projection lamellipodium membrane Peripheral membrane protein Cytoplasmic side Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock.
    Protein Attributes:
    Sequence length:
    166
    Sequence:
    50:
    MASGVAVSDG | VIKVFNDMKV | RKSSTPEEVK | KRKKAVLFCL | SEDKKNIILE | 
    100:
    EGKEILVGDV | GQTVDDPYTT | FVKMLPDKDC | RYALYDATYE | TKESKKEDLV | 
    150:
    FIFWAPENAP | LKSKMIYASS | KDAIKKKLTG | IKHELQANCY | EEVKDRCTLA | 
    166:
    EKLGGSAVIS | LEGKPL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Cofilin-1
    Cat.:
    E1525h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Cofilin-1
    Cat.:
    E1525m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse Cofilin-1
    MSDS:
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    ELISA Kit for Mouse Cofilin-1
    Cat.:
    E1525p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Cofilin-1
    Cat.:
    E1525b
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cofilin-1
    Cat.:
    U1525p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cofilin-1
    Cat.:
    U1525m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Cofilin-1
    Cat.:
    U1525h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse Cofilin-1
    Cat.:
    U1525r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Cofilin-1
    Cat.:
    U1525b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Cofilin-1
    Cat.:
    P1525Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Cofilin-1
    Cat.:
    P1525Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Cofilin-1
    Polyclonal Antibody for Mouse Cofilin-1
    Polyclonal Antibody for Mouse Cofilin-1
    Cat.:
    P1525Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Cofilin-1
    Monoclonal Antibody for Mouse Cofilin-1
    Monoclonal Antibody for Mouse Cofilin-1
    Monoclonal Antibody for Mouse Cofilin-1
    Monoclonal Antibody for Mouse Cofilin-1
    Protein for Mouse Cofilin-1
    Protein for Mouse Cofilin-1
    Protein for Mouse Cofilin-1
    Protein for Mouse Cofilin-1
    Protein for Mouse Cofilin-1

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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Swiss Webster.
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
    3. 3.
      Bienvenut W.V.
      Submitted (2005-07) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-13 AND 153-166;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
      strain: C57BL/6.
      tissue: Liver.
    4. 4.
      Lubec G. , Klug S.
      Submitted (2007-03) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 54-73 AND 96-112;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Hippocampus.
    5. 5.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-140;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    6. 6.
      "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
      Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Brain.
    7. 7.
      "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
      J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-68 AND TYR-140;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Mast cell.
    8. 8.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3 AND SER-8;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
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