Protein name:
Cofilin-1 ;
Alternative:
Cofilin, non-muscle isoform ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods.
Function:
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis.
Subcellular Location:
Nucleus matrix
Cytoplasm
cytoskeleton
Cell projection
ruffle membrane
Peripheral membrane protein
Cytoplasmic side
Cell projection
lamellipodium membrane
Peripheral membrane protein
Cytoplasmic side
Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock.
Protein Attributes:
50:
MASGVAVSDG | VIKVFNDMKV | RKSSTPEEVK | KRKKAVLFCL | SEDKKNIILE |
100:
EGKEILVGDV | GQTVDDPYTT | FVKMLPDKDC | RYALYDATYE | TKESKKEDLV |
150:
FIFWAPENAP | LKSKMIYASS | KDAIKKKLTG | IKHELQANCY | EEVKDRCTLA |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Pig
Bovine
ELISA Kit for Mouse Cofilin-1
ELISA Kit for Mouse Cofilin-1
ELISA Kit for Mouse Cofilin-1
ELISA Kit for Mouse Cofilin-1
ELISA Kit for Mouse Cofilin-1
CLIA Kit for Mouse Cofilin-1
CLIA Kit for Mouse Cofilin-1
CLIA Kit for Mouse Cofilin-1
CLIA Kit for Mouse Cofilin-1
CLIA Kit for Mouse Cofilin-1
Polyclonal Antibody for Mouse Cofilin-1
Polyclonal Antibody for Mouse Cofilin-1
Polyclonal Antibody for Mouse Cofilin-1
Polyclonal Antibody for Mouse Cofilin-1
Polyclonal Antibody for Mouse Cofilin-1
Monoclonal Antibody for Mouse Cofilin-1
Monoclonal Antibody for Mouse Cofilin-1
Monoclonal Antibody for Mouse Cofilin-1
Monoclonal Antibody for Mouse Cofilin-1
Monoclonal Antibody for Mouse Cofilin-1
Protein for Mouse Cofilin-1
Protein for Mouse Cofilin-1
Protein for Mouse Cofilin-1
Protein for Mouse Cofilin-1
Protein for Mouse Cofilin-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
Swiss Webster .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 2-13 AND 153-166;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY
strain :
C57BL/6 .
tissue :
Liver .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 54-73 AND 96-112;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Hippocampus .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-140;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Brain .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-68 AND TYR-140;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Mast cell .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3 AND SER-8;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .