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Index > Protein center > Cfl1(Gene name) > Rat
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  • Cfl1 (Gene name),
  • Cofilin-1 (Protein name ),  COF1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    Cfl1;
    Protein name:
    Cofilin-1;
    Alternative:
    Cofilin, non-muscle isoform;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods.
    Function:
    Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis.
    Subcellular Location:
    Nucleus matrix Cytoplasm cytoskeleton Cell projection ruffle membrane Peripheral membrane protein Cytoplasmic side Cell projection lamellipodium membrane Peripheral membrane protein Cytoplasmic side Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock.
    Protein Attributes:
    Sequence length:
    166
    Sequence:
    50:
    MASGVAVSDG | VIKVFNDMKV | RKSSTPEEVK | KRKKAVLFCL | SEDKKNIILE | 
    100:
    EGKEILVGDV | GQTVDDPYTT | FVKMLPDKDC | RYALYDATYE | TKESKKEDLV | 
    150:
    FIFWAPESAP | LKSKMIYASS | KDAIKKKLTG | IKHELQANCY | EEVKDRCTLA | 
    166:
    EKLGGSAVIS | LEGKPL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    String:
    UniGene:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Cofilin-1
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    E1525h
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    ELISA Kit for Rat Cofilin-1
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    E1525m
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    ELISA Kit for Rat Cofilin-1
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    ELISA Kit for Rat Cofilin-1
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    E1525p
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    ELISA Kit for Rat Cofilin-1
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    E1525b
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    96T
    CLIA Kit for Rat Cofilin-1
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    U1525p
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    CLIA Kit for Rat Cofilin-1
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    U1525m
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    MSDS:
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    96T
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    CLIA Kit for Rat Cofilin-1
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    U1525h
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    CLIA Kit for Rat Cofilin-1
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    U1525r
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    Packing:
    96T
    CLIA Kit for Rat Cofilin-1
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    U1525b
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    Packing:
    96T
    Polyclonal Antibody for Rat Cofilin-1
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    P1525Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Cofilin-1
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    P1525Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Cofilin-1
    Polyclonal Antibody for Rat Cofilin-1
    Polyclonal Antibody for Rat Cofilin-1
    Cat.:
    P1525Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Cofilin-1
    Monoclonal Antibody for Rat Cofilin-1
    Monoclonal Antibody for Rat Cofilin-1
    Monoclonal Antibody for Rat Cofilin-1
    Monoclonal Antibody for Rat Cofilin-1
    Protein for Rat Cofilin-1
    Protein for Rat Cofilin-1
    Protein for Rat Cofilin-1
    Protein for Rat Cofilin-1
    Protein for Rat Cofilin-1

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    References
    1. 1.
      Shirasawa T. , Takahashi H. , Sakamoto K. , Kawashima A. , Akashi T.
      Submitted (1991-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: Wistar.
      tissue: Brain.
    2. 2.
      "Complete amino acid sequences and phosphorylation sites, determined by Edman degradation and mass spectrometry, of rat parotid destrin- and cofilin-like proteins."
      Kanamori T. , Suzuki M. , Titani K.
      Arch. Oral Biol.43:955-967(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-166;ACETYLATION AT ALA-2;PHOSPHORYLATION AT SER-3;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: Parotid gland.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Ovary.
      tissue: Pituitary.
    4. 4.
      Lubec G. , Afjehi-Sadat L. , Chen W.-Q. , Kang S.U.
      Submitted (2007-07) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 35-73; 82-92; 96-112; 133-146 AND 153-166;IDENTIFICATION BY MASS SPECTROMETRY
      strain: Sprague-Dawley.
      tissue: Brain.
      tissue: Hippocampus.
      tissue: Spinal cord.
    5. 5.
      Lubec G. , Chen W.-Q.
      Submitted (2007-02) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT ALA-2;PHOSPHORYLATION AT SER-3;IDENTIFICATION BY MASS SPECTROMETRY
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