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Index > Protein center > POMC(Gene name) > Human
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  • POMC (Gene name),
  • Pro-opiomelanocortin (Protein name ),  COLI_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    POMC;
    Protein name:
    Pro-opiomelanocortin(POMC);
    Alternative:
    Corticotropin-lipotropin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Beta-endorphin and Met-enkephalin are endogenous opiates.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    267
    Sequence:
    50:
    MPRSCCSRSG | ALLLALLLQA | SMEVRGWCLE | SSQCQDLTTE | SNLLECIRAC | 
    100:
    KPDLSAETPM | FPGNGDEQPL | TENPRKYVMG | HFRWDRFGRR | NSSSSGSSGA | 
    150:
    GQKREDVSAG | EDCGPLPEGG | PEPRSDGAKP | GPREGKRSYS | MEHFRWGKPV | 
    200:
    GKKRRPVKVY | PNGAEDESAE | AFPLEFKREL | TGQRLREGDG | PDGPADDGAG | 
    250:
    AQADLEHSLL | VAAEKKDEGP | YRMEHFRWGS | PPKDKRYGGF | MTSEKSQTPL | 
    267:
    VTLFKNAIIK | NAYKKGE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    MIM:
    UniGene:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human POMC
    Cat.:
    E1311p
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human POMC
    Cat.:
    E1311m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human POMC
    Cat.:
    E1311h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human POMC
    MSDS:
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    ELISA Kit for Human POMC
    Cat.:
    E1311b
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human POMC
    Cat.:
    E1311r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human POMC
    Cat.:
    U1311r
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human POMC
    Cat.:
    U1311m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human POMC
    Cat.:
    U1311h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human POMC
    MSDS:
    Please sign in first.
    CLIA Kit for Human POMC
    Cat.:
    U1311p
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human POMC
    Cat.:
    U1311b
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human POMC
    Cat.:
    P1311Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human POMC
    Polyclonal Antibody for Human POMC
    Polyclonal Antibody for Human POMC
    Cat.:
    P1311Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human POMC
    Polyclonal Antibody for Human POMC
    Cat.:
    P1311Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human POMC
    Monoclonal Antibody for Human POMC
    Monoclonal Antibody for Human POMC
    Monoclonal Antibody for Human POMC
    Monoclonal Antibody for Human POMC
    Monoclonal Antibody for Human POMC
    Protein for Human POMC
    Protein for Human POMC
    Protein for Human POMC
    Protein for Human POMC
    Protein for Human POMC
    Protein for Human POMC

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and structural organization of the human corticotropin-beta-lipotropin precursor gene."
      Takahashi H. , Teranishi Y. , Nakanishi S. , Numa S.
      FEBS Lett.135:97-102(1981) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "The human pro-opiomelanocortin gene: organization, sequence, and interspersion with repetitive DNA."
      Whitfeld P.L. , Seeburg P.H. , Shine J.
      DNA1:133-143(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Complete nucleotide sequence of the human corticotropin-beta-lipotropin precursor gene."
      Takahashi H. , Hakamata Y. , Watanabe Y. , Kikuno R. , Miyata T. , Numa S.
      Nucleic Acids Res.11:6847-6858(1983) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pituitary.
    7. 7.
      "Synthesis, cloning and primary structure of DNA complementary to mRNA for human pituitary pro-opiomelanocortin."
      Golovin S.Y. , Karginov V.A. , Bondar A.A. , Beklemishev A.B. , Chekhranova M.K. , Mertvetsov N.P. , Pankov Y.A.
      Bioorg. Khim.13:562-564(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-267
    8. 8.
      "Structural organization of human genomic DNA encoding the pro-opiomelanocortin peptide."
      Chang A.C.Y. , Cochet M. , Cohen S.N.
      Proc. Natl. Acad. Sci. U.S.A.77:4890-4894(1980) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 46-267
    9. 9.
      "Complete amino acid sequence of a human pituitary glycopeptide: an important maturation product of pro-opiomelanocortin."
      Seidah N.G. , Chretien M.
      Proc. Natl. Acad. Sci. U.S.A.78:4236-4240(1981) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-102
    10. 10.
      "Primary structure of the major human pituitary pro-opiomelanocortin NH2-terminal glycopeptide. Evidence for an aldosterone-stimulating activity."
      Seidah N.G. , Rochemont J. , Hamelin J. , Lis M. , Chretien M.
      J. Biol. Chem.256:7977-7984(1981) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-102
    11. 11.
      "The missing fragment of the pro-sequence of human pro-opiomelanocortin: sequence and evidence for C-terminal amidation."
      Seidah N.G. , Rochemont J. , Hamelin J. , Benjannet S. , Chretien M.
      Biochem. Biophys. Res. Commun.102:710-716(1981) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 105-134;AMIDATION AT GLU-134
    12. 12.
      "Confirmation of the 1-20 amino acid sequence of human adrenocorticotrophin."
      Bennett H.P.J. , Lowry P.J. , McMartin C.
      Biochem. J.133:11-13(1973) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 138-176
    13. 13.
      "On the structure of human corticotropin (adrenocorticotropic hormone)."
      Lee T.H. , Lerner A.B. , Buettner-Janusch V.
      J. Biol. Chem.236:2970-2974(1961) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 138-176
    14. 14.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 27-41
    15. 15.
      "Revised amino-acid sequences for porcine and human adrenocorticotrophic hormone."
      Riniker B. , Sieber P. , Rittel W. , Zuber H.
      Nature New Biol.235:114-115(1972) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION (CORTICOTROPIN)
    16. 16.
      "Synthesis of the human adrenal cortex hormone (alpha-h-ACTH) with a revised amino-acid sequence."
      Sieber P. , Rittel W. , Riniker B.
      Helv. Chim. Acta55:1243-1266(1972) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS OF CORTICOTROPIN
    17. 17.
      "Adrenocorticotropins. 44. Total synthesis of the human hormone by the solid-phase method."
      Yamashiro D. , Li C.H.
      J. Am. Chem. Soc.95:1310-1315(1973) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SYNTHESIS OF CORTICOTROPIN
    18. 18.
      "Primary structure of human beta-lipotropin."
      Li C.H. , Chung D.
      Nature260:622-624(1976) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 179-267
    19. 19.
      "Structure of a melanocyte-stimulating hormone from the human pituitary gland."
      Harris J.I.
      Nature184:167-169(1959)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 217-234
    20. 20.
      "Primary structure and morphine-like activity of human beta-endorphin."
      Dragon N. , Seidah N.G. , Lis M. , Routhier R. , Chretien M.
      Can. J. Biochem.55:666-670(1977) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 237-267
    21. 21.
      "Gamma-endorphin and schizophrenia: amino acid composition of gamma-endorphin and nucleotide sequence of gamma-endorphin cDNA from pituitary glands of schizophrenic patients."
      Bovenberg R.A.L. , Burbach J.P.H. , Wiegant V.M. , Veeneman G.H. , van Boom J.H. , Baas P.D. , Jansz H.S. , de Wied D.
      Brain Res.376:29-37(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 235-256
    22. 22.
      "Alpha-amidated peptides derived from pro-opiomelanocortin in normal human pituitary."
      Fenger M. , Johnsen A.H.
      Biochem. J.250:781-788(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    23. 23.
      "Reduced expression of a naturally deleted form of human proopiomelanocortin complementary deoxyribonucleic acid after transfection into Chinese hamster ovary cells."
      Morris J.C. , Savva D. , Lowry P.J.
      Endocrinology136:195-201(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 75-104;VARIANT 97-SER--GLY-99 DEL
      tissue: Pituitary.
    24. 24.
      "Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans."
      Krude H. , Biebermann H. , Luck W. , Horn R. , Brabant G. , Grueters A.
      Nat. Genet.19:155-157(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN POMCD
    25. 25.
      "Association between common polymorphisms of the proopiomelanocortin gene and body fat distribution: a family study."
      Baker M. , Gaukrodger N. , Mayosi B.M. , Imrie H. , Farrall M. , Watkins H. , Connell J.M.C. , Avery P.J. , Keavney B.
      Diabetes54:2492-2496(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ABDOMINAL BODY FAT DISTRIBUTION
    26. 26.
      "Phosphoproteomic analysis of the human pituitary."
      Beranova-Giorgianni S. , Zhao Y. , Desiderio D.M. , Giorgianni F.
      Pituitary9:109-120(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-168;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Pituitary.
    27. 27.
      "Systematic mutation screening of the pro-opiomelanocortin gene: identification of several genetic variants including three different insertions, one nonsense and two missense point mutations in probands of different weight extremes."
      Hinney A. , Becker I. , Heibult O. , Nottebom K. , Schmidt A. , Ziegler A. , Mayer H. , Siegfried W. , Blum W.F. , Remschmidt H. , Hebebrand J.
      J. Clin. Endocrinol. Metab.83:3737-3741(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASN-106; GLY-214 AND 97-SER--GLY-99 DEL
    28. 28.
      "Mutational analysis of the proopiomelanocortin gene in Caucasians with early onset obesity."
      Echwald S.M. , Sorensen T.I. , Andersen T. , Tybjaerg-Hansen A. , Clausen J.O. , Pedersen O.
      Int. J. Obes. Relat. Metab. Disord.23:293-298(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLN-236
    29. 29.
      "Molecular screening of the proopiomelanocortin (POMC) gene in Italian obese children: report of three new mutations."
      del Giudice E.M. , Cirillo G. , Santoro N. , D'Urso L. , Carbone M.T. , Toro R.D. , Perrone L.
      Int. J. Obes. Relat. Metab. Disord.25:61-67(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-7; LEU-9; GLY-236 AND 97-SER--GLY-99 DEL
    30. 30.
      "A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism."
      Challis B.G. , Pritchard L.E. , Creemers J.W.M. , Delplanque J. , Keogh J.M. , Luan J. , Wareham N.J. , Yeo G.S.H. , Bhattacharyya S. , Froguel P. , White A. , Farooqi I.S. , O'Rahilly S.
      Hum. Mol. Genet.11:1997-2004(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLY-236;CHARACTERIZATION OF VARIANT GLY-236;POSSIBLE INVOLVEMENT IN OBESITY
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