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Index > Protein center > COMT(Gene name) > Human
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  • COMT (Gene name),
  • Catechol O-methyltransferase (Protein name ),  COMT_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    COMT;
    Protein name:
    Catechol O-methyltransferase;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
    Subcellular Location:
    Isoform Membrane-bound Cell membrane Single-pass type II membrane protein Extracellular side
    Protein Attributes:
    Sequence length:
    271
    Sequence:
    50:
    MPEAPPLLLA | AVLLGLVLLV | VLLLLLRHWG | WGLCLIGWNE | FILQPIHNLL | 
    100:
    MGDTKEQRIL | NHVLQHAEPG | NAQSVLEAID | TYCEQKEWAM | NVGDKKGKIV | 
    150:
    DAVIQEHQPS | VLLELGAYCG | YSAVRMARLL | SPGARLITIE | INPDCAAITQ | 
    200:
    RMVDFAGVKD | KVTLVVGASQ | DIIPQLKKKY | DVDTLDMVFL | DHWKDRYLPD | 
    250:
    TLLLEECGLL | RKGTVLLADN | VICPGAPDFL | AHVRGSSCFE | CTHYQSFLEY | 
    271:
    REVVDGLEKA | IYKGPGSEAG | P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    String:
    Pfam:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Catechol O-methyltransferase
    Cat.:
    E9267h
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    ELISA Kit for Human Catechol O-methyltransferase
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    ELISA Kit for Human Catechol O-methyltransferase
    Cat.:
    E9267m
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    Packing:
    96T
    ELISA Kit for Human Catechol O-methyltransferase
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    E9267r
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    ELISA Kit for Human Catechol O-methyltransferase
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    E9267b
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    Packing:
    96T
    CLIA Kit for Human Catechol O-methyltransferase
    Cat.:
    U9267b
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    Packing:
    96T
    CLIA Kit for Human Catechol O-methyltransferase
    Cat.:
    U9267m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Catechol O-methyltransferase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Catechol O-methyltransferase
    Cat.:
    U9267h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
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    CLIA Kit for Human Catechol O-methyltransferase
    Cat.:
    U9267r
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Catechol O-methyltransferase
    Polyclonal Antibody for Human Catechol O-methyltransferase
    Cat.:
    P9267Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Catechol O-methyltransferase
    Polyclonal Antibody for Human Catechol O-methyltransferase
    Cat.:
    P9267Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Catechol O-methyltransferase
    Monoclonal Antibody for Human Catechol O-methyltransferase
    Monoclonal Antibody for Human Catechol O-methyltransferase
    Monoclonal Antibody for Human Catechol O-methyltransferase
    Monoclonal Antibody for Human Catechol O-methyltransferase
    Monoclonal Antibody for Human Catechol O-methyltransferase
    Protein for Human Catechol O-methyltransferase
    Protein for Human Catechol O-methyltransferase
    Protein for Human Catechol O-methyltransferase
    Protein for Human Catechol O-methyltransferase
    Protein for Human Catechol O-methyltransferase

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    Precision
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of human placental catechol-O-methyltransferase cDNA."
      Lundstroem K. , Salminen M. , Jalanko A. , Savolainen R. , Ulmanen I.
      DNA Cell Biol.10:181-189(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Placenta.
    2. 2.
      "Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form."
      Bertocci B. , Miggiano V. , da Prada M. , Dembic Z. , Lahm H.-W. , Malherbe P.
      Proc. Natl. Acad. Sci. U.S.A.88:1416-1420(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT SER-34
    3. 3.
      "Genomic organization of the human catechol O-methyltransferase gene and its expression from two distinct promoters."
      Tenhunen J. , Salminen M. , Lundstroem K. , Kiviluoto T. , Savolainen R. , Ulmanen I.
      Eur. J. Biochem.223:1049-1059(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      Li J.Y. , Wang H.Y. , Liu J. , Liu F.J.
      Submitted (2008-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-158
    7. 7.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      NIEHS SNPs program
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS SER-72 AND MET-158
    9. 9.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT MET-158
    11. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Muscle.
      tissue: Skin.
    12. 12.
      "Mass spectrometric analysis of human soluble catechol O-methyltransferase expressed in Escherichia coli. Identification of a product of ribosomal frameshifting and of reactive cysteines involved in S-adenosyl-L-methionine binding."
      Vilbois F. , Caspers P. , da Prada M. , Lang G. , Karrer C. , Lahm H.W. , Cesura A.M.
      Eur. J. Biochem.222:377-386(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 52-61;MASS SPECTROMETRY
    13. 13.
      "Purification and partial sequence analysis of the soluble catechol-O-methyltransferase from human placenta: comparison to the rat liver enzyme."
      Tilgmann C. , Kalkkinen N.
      Biochem. Biophys. Res. Commun.174:995-1002(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 59-271
      tissue: Placenta.
    14. 14.
      "Cell-free synthesis of rat and human catechol O-methyltransferase. Insertion of the membrane-bound form into microsomal membranes in vitro."
      Ulmanen I. , Lundstroem K.
      Eur. J. Biochem.202:1013-1020(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF THE TWO FORMS
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    16. 16.
      "Crystal structures of human 108V and 108M catechol O-methyltransferase."
      Rutherford K. , Le Trong I. , Stenkamp R.E. , Parson W.W.
      J. Mol. Biol.380:120-130(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 52-264 OF MUTANTS VAL-108 AND MET-108 IN COMPLEX WITH SUBSTRATE ANALOG 3,5-DINITROCATECHOL; MAGNESIUM AND S-ADENOSYL-L-METHIONINE
    17. 17.
      "Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders."
      Lachman H.M. , Papolos D.F. , Saito T. , Yu Y.-M. , Szumlanski C.L. , Weinshilboum R.M.
      Pharmacogenetics6:243-250(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT COMT*2 MET-158
    18. 18.
      "Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism."
      Tiihonen J. , Hallikainen T. , Lachman H. , Saito T. , Volavka J. , Kauhanen J. , Salonen J.T. , Ryynaenen O.-P. , Koulu M. , Karvonen M.K. , Pohjalainen T. , Syvaelahti E. , Hietala J.
      Mol. Psychiatry4:286-289(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SER-34 AND SER-72
    20. 20.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    21. 21.
      "Association of Ala72Ser polymorphism with COMT enzyme activity and the risk of schizophrenia in Koreans."
      Lee S.-G. , Joo Y. , Kim B. , Chung S. , Kim H.-L. , Lee I. , Choi B. , Kim C. , Song K.
      Hum. Genet.116:319-328(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT SER-72;POSSIBLE INVOLVEMENT IN SCHIZOPHRENIA
    22. 22.
      "The V108M mutation decreases the structural stability of catechol O-methyltransferase."
      Rutherford K. , Alphandery E. , McMillan A. , Daggett V. , Parson W.W.
      Biochim. Biophys. Acta1784:1098-1105(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT COMT*2 MET-158
    23. 23.
      "Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men."
      Annerbrink K. , Westberg L. , Nilsson S. , Rosmond R. , Holm G. , Eriksson E.
      Metabolism57:708-711(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT COMT*2 MET-158
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