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Index > Protein center > CYP1A1(Gene name) > Human
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  • CYP1A1 (Gene name),
  • Cytochrome P450 1A1 (Protein name ),  CP1A1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    CYP1A1;
    Protein name:
    Cytochrome P450 1A1;
    Alternative:
    Cytochrome P450 form 6;CYPIA1;Cytochrome P450-P1;Cytochrome P450-C;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
    Subcellular Location:
    Endoplasmic reticulum membrane Peripheral membrane protein Microsome membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    512
    Sequence:
    50:
    MLFPISMSAT | EFLLASVIFC | LVFWVIRASR | PQVPKGLKNP | PGPWGWPLIG | 
    100:
    HMLTLGKNPH | LALSRMSQQY | GDVLQIRIGS | TPVVVLSGLD | TIRQALVRQG | 
    150:
    DDFKGRPDLY | TFTLISNGQS | MSFSPDSGPV | WAARRRLAQN | GLKSFSIASD | 
    200:
    PASSTSCYLE | EHVSKEAEVL | ISTLQELMAG | PGHFNPYRYV | VVSVTNVICA | 
    250:
    ICFGRRYDHN | HQELLSLVNL | NNNFGEVVGS | GNPADFIPIL | RYLPNPSLNA | 
    300:
    FKDLNEKFYS | FMQKMVKEHY | KTFEKGHIRD | ITDSLIEHCQ | EKQLDENANV | 
    350:
    QLSDEKIINI | VLDLFGAGFD | TVTTAISWSL | MYLVMNPRVQ | RKIQEELDTV | 
    400:
    IGRSRRPRLS | DRSHLPYMEA | FILETFRHSS | FVPFTIPHST | TRDTSLKGFY | 
    450:
    IPKGRCVFVN | QWQINHDQKL | WVNPSEFLPE | RFLTPDGAID | KVLSEKVIIF | 
    500:
    GMGKRKCIGE | TIARWEVFLF | LAILLQRVEF | SVPLGVKVDM | TPIYGLTMKH | 
    512:
    ACCEHFQMQL | RS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    UniGene:
    MIM:
    Pfam:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Cytochrome P450 1A1
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    E10138r
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    ELISA Kit for Human Cytochrome P450 1A1
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    ELISA Kit for Human Cytochrome P450 1A1
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    ELISA Kit for Human Cytochrome P450 1A1
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    E10138m
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    ELISA Kit for Human Cytochrome P450 1A1
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    CLIA Kit for Human Cytochrome P450 1A1
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    U10138r
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    96T
    CLIA Kit for Human Cytochrome P450 1A1
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    U10138h
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human Cytochrome P450 1A1
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    Please sign in first.
    CLIA Kit for Human Cytochrome P450 1A1
    MSDS:
    Please sign in first.
    CLIA Kit for Human Cytochrome P450 1A1
    Cat.:
    U10138m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Cytochrome P450 1A1
    Polyclonal Antibody for Human Cytochrome P450 1A1
    Polyclonal Antibody for Human Cytochrome P450 1A1
    Polyclonal Antibody for Human Cytochrome P450 1A1
    Polyclonal Antibody for Human Cytochrome P450 1A1
    Cat.:
    P10138Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Cytochrome P450 1A1
    Monoclonal Antibody for Human Cytochrome P450 1A1
    Monoclonal Antibody for Human Cytochrome P450 1A1
    Monoclonal Antibody for Human Cytochrome P450 1A1
    Monoclonal Antibody for Human Cytochrome P450 1A1
    Protein for Human Cytochrome P450 1A1
    Protein for Human Cytochrome P450 1A1
    Protein for Human Cytochrome P450 1A1
    Protein for Human Cytochrome P450 1A1
    Protein for Human Cytochrome P450 1A1

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    References
    1. 1.
      "Human P1-450 gene sequence and correlation of mRNA with genetic differences in benzo[a]pyrene metabolism."
      Jaiswal A.K. , Gonzales F.J. , Nebert D.W.
      Nucleic Acids Res.13:4503-4520(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Human dioxin-inducible cytochrome P1-450: complementary DNA and amino acid sequence."
      Jaiswal A.K. , Gonzalez F.J. , Nebert D.W.
      Science228:80-83(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Structure and drug inducibility of the human cytochrome P-450c gene."
      Kawajiri K. , Watanabe J. , Gotoh O. , Tagashira Y. , Sogawa K. , Fujii-Kuriyama Y.
      Eur. J. Biochem.159:219-225(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    4. 4.
      "Organization of the CYP1A cluster on human chromosome 15: implications for gene regulation."
      Corchero J. , Pimprale S. , Kimura S. , Gonzalez F.J.
      Pharmacogenetics11:1-6(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Cloning and sequencing of new alternative splicing variants of human CYP1A1 gene."
      Graebsch C. , Bauer M.
      Submitted (2006-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3)
      tissue: Blood.
    6. 6.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ASP-45
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Cervix.
    8. 9.
      "Identification of cytochrome P450 1A1 in human brain."
      Yun C.H. , Park H.J. , Kim S.J. , Kim H.K.
      Biochem. Biophys. Res. Commun.243:808-810(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 282-425 (ISOFORM 1)
      tissue: Brain.
    9. 10.
      "Cloning and isolation of human cytochrome P-450 cDNAs homologous to dioxin-inducible rabbit mRNAs encoding P-450 4 and P-450 6."
      Quattrochi L.C. , Okino S.T. , Pendurthi U.R. , Tukey R.H.
      DNA4:395-400(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 295-484 (ISOFORM 1)
    10. 11.
      "Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism."
      Walsh A.A. , Szklarz G.D. , Scott E.E.
      J. Biol. Chem.288:12932-12943(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 35-512 IN COMPLEX WITH HEME AND INHIBITOR ALPHA-NAPHTOFLAVONE;COFACTOR
    11. 12.
      "Genetic linkage of lung cancer-associated MspI polymorphisms with amino acid replacement in the heme binding region of the human cytochrome P450IA1 gene."
      Hayashi S. , Watanabe J. , Nakachi K. , Kawajiri K.
      J. Biochem.110:407-411(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VAL-462
    12. 13.
      "A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and impact on lung cancer susceptibility."
      Cascorbi I. , Brockmoller J. , Roots I.
      Cancer Res.56:4965-4969(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ASN-461
    13. 14.
      "Variation in induced CYP1A1 levels: relationship to CYP1A1, Ah receptor and GSTM1 polymorphisms."
      Smart J. , Daly A.K.
      Pharmacogenetics10:11-24(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT TRP-279
    14. 15.
      "Detection of known and two novel (M331I and R464S) missense mutations in the human CYP1A1 gene in a French Caucasian population."
      Chevalier D. , Allorge D. , Lo-Guidice J.-M. , Cauffiez C. , Lhermitte M. , Lafitte J.-J. , Broly F.
      Hum. Mutat.17:355-355(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ILE-331 AND SER-464
    15. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASN-448; CYS-464; TRP-477 AND ARG-492
    16. 17.
      "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
      Solus J.F. , Arietta B.J. , Harris J.R. , Sexton D.P. , Steward J.Q. , McMunn C. , Ihrie P. , Mehall J.M. , Edwards T.L. , Dawson E.P.
      Pharmacogenomics5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-45; THR-78; TRP-93; ARG-173; ASN-461; MET-482 AND ARG-492
    17. 18.
      "Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus."
      Jiang Z. , Dalton T.P. , Jin L. , Wang B. , Tsuneoka Y. , Shertzer H.G. , Deka R. , Nebert D.W.
      Hum. Mutat.25:196-206(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ASP-45; THR-78; ASN-461 AND VAL-462
    18. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] TRP-477
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