Gene name:
Cyp24a1(Cyp24);
Protein name:
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial(24-OHase;Vitamin D(3) 24-hydroxylase);
Alternative:
Cytochrome P450 24A1;Cytochrome P450-CC24;
Organism:
Rat (Rattus norvegicus).
General annotation
Function:
Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid.
Subcellular Location:
Mitochondrion
Protein attributes
50:
MSCPIDKRRT | LIAFLRRLRD | LGQPPRSVTS | KASASRAPKE | VPLCPLMTDG |
100:
ETRNVTSLPG | PTNWPLLGSL | LEIFWKGGLK | KQHDTLAEYH | KKYGQIFRMK |
150:
LGSFDSVHLG | SPSLLEALYR | TESAHPQRLE | IKPWKAYRDH | RNEAYGLMIL |
200:
EGQEWQRVRS | AFQKKLMKPV | EIMKLDKKIN | EVLADFLERM | DELCDERGRI |
250:
PDLYSELNKW | SFESICLVLY | EKRFGLLQKE | TEEEALTFIT | AIKTMMSTFG |
300:
KMMVTPVELH | KRLNTKVWQA | HTLAWDTIFK | SVKPCIDNRL | QRYSQQPGAD |
350:
FLCDIYQQDH | LSKKELYAAV | TELQLAAVET | TANSLMWILY | NLSRNPQAQR |
400:
RLLQEVQSVL | PDNQTPRAED | LRNMPYLKAC | LKESMRLTPS | VPFTTRTLDK |
450:
PTVLGEYALP | KGTVLTLNTQ | VLGSSEDNFE | DSHKFRPERW | LQKEKKINPF |
500:
AHLPFGIGKR | MCIGRRLAEL | QLHLALCWII | QKYDIVATDN | EPVEMLHLGI |

Vaild
Sequence:
Database Reference
Uniprot: