Gene name:
CYP2C9(CYP2C10);
Protein name:
Cytochrome P450 2C9;
Alternative:
1.14.13.48;(S)-limonene 6-monooxygenase);1.14.13.80;(R)-limonene 6-monooxygenase);CYPIIC9;1.14.13.49;(S)-limonene 7-monooxygenase);Cytochrome P450 MP-4;Cytochrome P-450MP;Cytochrome P450 PB-1;Cytochrome P450 MP-8;S-mephenytoin 4-hydroxylase;
Organism:
Human (Homo sapiens).
General Annotation
Function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This enzyme contributes to the wide pharmacokinetics variability of the metabolism of drugs such as S-warfarin, diclofenac, phenytoin, tolbutamide and losartan.
Subcellular Location:
Endoplasmic reticulum membrane
Peripheral membrane protein
Microsome membrane
Peripheral membrane protein
Protein Attributes:
50:
MDSLVVLVLC | LSCLLLLSLW | RQSSGRGKLP | PGPTPLPVIG | NILQIGIKDI |
100:
SKSLTNLSKV | YGPVFTLYFG | LKPIVVLHGY | EAVKEALIDL | GEEFSGRGIF |
150:
PLAERANRGF | GIVFSNGKKW | KEIRRFSLMT | LRNFGMGKRS | IEDRVQEEAR |
200:
CLVEELRKTK | ASPCDPTFIL | GCAPCNVICS | IIFHKRFDYK | DQQFLNLMEK |
250:
LNENIKILSS | PWIQICNNFS | PIIDYFPGTH | NKLLKNVAFM | KSYILEKVKE |
300:
HQESMDMNNP | QDFIDCFLMK | MEKEKHNQPS | EFTIESLENT | AVDLFGAGTE |
350:
TTSTTLRYAL | LLLLKHPEVT | AKVQEEIERV | IGRNRSPCMQ | DRSHMPYTDA |
400:
VVHEVQRYID | LLPTSLPHAV | TCDIKFRNYL | IPKGTTILIS | LTSVLHDNKE |
450:
FPNPEMFDPH | HFLDEGGNFK | KSKYFMPFSA | GKRICVGEAL | AGMELFLFLT |
490:
SILQNFNLKS | LVDPKNLDTT | PVVNGFASVP | PFYQLCFIPV |
Vaild Sequence:
Related Databases
Uniprot: