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Index > Protein center > CRBN(Gene name) > Human
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  • CRBN (Gene name),
  • Protein cereblon (Protein name ),  CRBN_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    CRBN(AD-006);
    Protein name:
    Protein cereblon;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with KCNT1 (By similarity). Component of a DCX (DDB1-CUL4-X-box) protein ligase complex, at least composed of CRBN, CUL4A, DDB1 and RBX1.
    Function:
    Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1.
    Subcellular Location:
    Cytoplasm Nucleus Membrane Peripheral membrane protein
    Protein Attributes:
    Sequence length:
    442
    Sequence:
    50:
    MAGEGDQQDA | AHNMGNHLPL | LPAESEEEDE | MEVEDQDSKE | AKKPNIINFD | 
    100:
    TSLPTSHTYL | GADMEEFHGR | TLHDDDSCQV | IPVLPQVMMI | LIPGQTLPLQ | 
    150:
    LFHPQEVSMV | RNLIQKDRTF | AVLAYSNVQE | REAQFGTTAE | IYAYREEQDF | 
    200:
    GIEIVKVKAI | GRQRFKVLEL | RTQSDGIQQA | KVQILPECVL | PSTMSAVQLE | 
    250:
    SLNKCQIFPS | KPVSREDQCS | YKWWQKYQKR | KFHCANLTSW | PRWLYSLYDA | 
    300:
    ETLMDRIKKQ | LREWDENLKD | DSLPSNPIDF | SYRVAACLPI | DDVLRIQLLK | 
    350:
    IGSAIQRLRC | ELDIMNKCTS | LCCKQCQETE | ITTKNEIFSL | SLCGPMAAYV | 
    400:
    NPHGYVHETL | TVYKACNLNL | IGRPSTEHSW | FPGYAWTVAQ | CKICASHIGW | 
    442:
    KFTATKKDMS | PQKFWGLTRS | ALLPTIPDTE | DEISPDKVIL | CL
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    String:
    MIM:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein cereblon
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    E12793h
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    ELISA Kit for Human Protein cereblon
    MSDS:
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    ELISA Kit for Human Protein cereblon
    MSDS:
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    ELISA Kit for Human Protein cereblon
    Cat.:
    E12793m
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    Packing:
    96T
    ELISA Kit for Human Protein cereblon
    Cat.:
    E12793r
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    Packing:
    96T
    CLIA Kit for Human Protein cereblon
    Cat.:
    U12793r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Protein cereblon
    MSDS:
    Please sign in first.
    CLIA Kit for Human Protein cereblon
    MSDS:
    Please sign in first.
    CLIA Kit for Human Protein cereblon
    Cat.:
    U12793h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Protein cereblon
    Cat.:
    U12793m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Protein cereblon
    Cat.:
    P12793Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Protein cereblon
    Polyclonal Antibody for Human Protein cereblon
    Polyclonal Antibody for Human Protein cereblon
    Polyclonal Antibody for Human Protein cereblon
    Monoclonal Antibody for Human Protein cereblon
    Monoclonal Antibody for Human Protein cereblon
    Monoclonal Antibody for Human Protein cereblon
    Monoclonal Antibody for Human Protein cereblon
    Monoclonal Antibody for Human Protein cereblon
    Protein for Human Protein cereblon
    Protein for Human Protein cereblon
    Protein for Human Protein cereblon
    Protein for Human Protein cereblon
    Protein for Human Protein cereblon

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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
      tissue: Lung.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-442
      tissue: Adrenal gland.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 64-250
      tissue: Fetal kidney.
    6. 6.
      "A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation."
      Higgins J.J. , Pucilowska J. , Lombardi R.Q. , Rooney J.P.
      Neurology63:1927-1931(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MRT2A;TISSUE SPECIFICITY
    7. 7.
      "Primary function analysis of human mental retardation related gene CRBN."
      Xin W. , Xiaohua N. , Peilin C. , Xin C. , Yaqiong S. , Qihan W.
      Mol. Biol. Rep.35:251-256(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    8. 8.
      "Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation."
      Higgins J.J. , Hao J. , Kosofsky B.E. , Rajadhyaksha A.M.
      Neurogenetics9:219-223(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "Identification of a primary target of thalidomide teratogenicity."
      Ito T. , Ando H. , Suzuki T. , Ogura T. , Hotta K. , Imamura Y. , Yamaguchi Y. , Handa H.
      Science327:1345-1350(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN A DCX COMPLEX WITH DDB1; RBX1 AND CUL4A;THALIDOMIDE-BINDING;UBIQUITINATION;MUTAGENESIS OF TYR-384 AND TRP-386
    10. 10.
      "Immunomodulatory agents lenalidomide and pomalidomide co-stimulate T cells by inducing degradation of T cell repressors Ikaros and Aiolos via modulation of the E3 ubiquitin ligase complex CRL4(CRBN.)."
      Gandhi A.K. , Kang J. , Havens C.G. , Conklin T. , Ning Y. , Wu L. , Ito T. , Ando H. , Waldman M.F. , Thakurta A. , Klippel A. , Handa H. , Daniel T.O. , Schafer P.H. , Chopra R.
      Br. J. Haematol.164:811-821(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MISCELLANEOUS
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DDB1;UBIQUITINATION
    12. 12.
      "Structure of the human cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs."
      Chamberlain P.P. , Lopez-Girona A. , Miller K. , Carmel G. , Pagarigan B. , Chie-Leon B. , Rychak E. , Corral L.G. , Ren Y.J. , Wang M. , Riley M. , Delker S.L. , Ito T. , Ando H. , Mori T. , Hirano Y. , Handa H. , Hakoshima T. , more...
      Nat. Struct. Mol. Biol.21:803-809(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.01 ANGSTROMS) OF 48-428 IN COMPLEX WITH DDB1; S-LENALIDOMIDE AND ZINC;FUNCTION;INTERACTION WITH DDB1;DOMAIN;MUTAGENESIS OF TRP-386;MISCELLANEOUS
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