Interacts (via N-terminal extracellular domain) with CRF, UCN, UCN2 and UCN3. Has highest affinity for UCN, and considerably lower affinity for CRF, UNC2 and UCN3.
Function:
This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
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Precision
Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Intra-Assay CV: ≤3.7%
Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.
Inter-Assay CV: ≤6.5%
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Recovery
Recovery was determined by spiking various levels of CRFR2 into serum and plasma .
Sample Type
Average(%)
Recovery Range(%)
Serum
99
93-103
Plasma
98
95-100
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Linearity
The linearity of the kit was assayed by testing samples spiked with appropriate concentration of CRFR2 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.
Sample
1:2
1:4
1:8
1:16
serum(n=5)
95-100%
96-102%
95-99%
97-104%
EDTA plasma(n=5)
93-97%
95-100%
92-100%
96-102%
heparin plasma(n=5)
95-104%
93-104%
102-108%
91-97%
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CRF2-ALPHA)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CRF2-GAMMA)
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM CRF2-ALPHA)
5.
"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." King M.M.
,
Aronstam R.S.
,
Sharma S.V.
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CRF2-ALPHA)
"Identification and characterization of novel CRF receptor type 2 isoforms in human." Wu S.V.
,
Yuan P.-Q.
,
Lai J.
,
Tache Y.
Submitted (2007-07) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS D; E; F AND DESQ);ALTERNATIVE SPLICING
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CRF2-ALPHA)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM CRF2-ALPHA)
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-88 (ISOFORM CRF2-BETA)
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Cited for: SUBUNIT;SUBCELLULAR LOCATION;NON-CLEAVABLE SIGNAL SEQUENCE
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Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 3-104 IN COMPLEXES WITH UCN; UCN2 AND UCN3;INTERACTION WITH CRF; UCN; UCN2 AND UCN3;DISULFIDE BONDS