CSF3R ELISA Kit for Human(Homo sapiens) | EIAab.comCSF3R ELISA Kit for Human(Homo sapiens)

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Index > Protein center > CSF3R(Gene name) > Human

CSF3R (Gene name),

Granulocyte colony-stimulating factor receptor (Protein name ), CSF3R_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

CSF3R(GCSFR);

Protein name:

Granulocyte colony-stimulating factor receptor(G-CSF receptor;G-CSF-R);

Alternative:

CD:

CD114;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. The dimeric receptor binds two CSF3 molecules.

Function:

Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

836

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

836:

VTPAPSQEDD | CVFGPLLNFP | LLQGIRVHGM | EALGSF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000342623

MIM:

138971

SMR:

Q99062

KEGG:

hsa:1441

Pfam:

PF00041

UniGene:

Hs.524517

String:

Q99062

Uniprot:

Q99062

FOR

ELISA Kit for Human G-CSF receptor

Cat.:

E2217h

Price:

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MSDS:

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Packing:

96T

ELISA Kit for Human G-CSF receptor

Cat.:

E2217m

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MSDS:

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Packing:

96T

CLIA Kit for Human G-CSF receptor

Cat.:

U2217h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human G-CSF receptor

Cat.:

U2217m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human G-CSF receptor

Cat.:

P2217Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human G-CSF receptor

Cat.:

P2217Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human G-CSF receptor

Protein for Human G-CSF receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains."
Larsen A. , Davis T. , Curtis B.M. , Gimpel S. , Sims J.E. , Cosman D. , Park L. , Sorensen E. , March C.J. , Smith C.A.
J. Exp. Med.172:1559-1570(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 4)
tissue: Placenta.
2.

"Three different mRNAs encoding human granulocyte colony-stimulating factor receptor."
Fukunaga R. , Seto Y. , Mizushima S. , Nagata S.
Proc. Natl. Acad. Sci. U.S.A.87:8702-8706(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
tissue: Placenta.
3.

"Chromosomal gene organization of the human granulocyte colony-stimulating factor receptor."
Seto Y. , Fukunaga R. , Nagata S.
J. Immunol.148:259-266(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

SeattleSNPs variation discovery resource
Submitted (2002-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-231; ASN-320; ARG-346; LYS-405; GLN-440; HIS-510; HIS-562 AND CYS-583
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Blood.
6.

"Extracellular domain of granulocyte-colony stimulating factor receptor. Interaction with its ligand and identification of a domain in close proximity of ligand-binding region."
Haniu M. , Horan T. , Arakawa T. , Le J. , Katta V. , Rohde M.F.
Arch. Biochem. Biophys.324:344-356(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 234-269
7.

"Functional domains of the granulocyte colony-stimulating factor receptor."
Fukunaga R. , Ishizaka-Ikeda E. , Pan C.-X. , Seto Y. , Nagata S.
EMBO J.10:2855-2865(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAINS
8.

"Identification of a nonsense mutation in the granulocyte-colony-stimulating factor receptor in severe congenital neutropenia."
Dong F. , Hoefsloot L.H. , Schelen A.M. , Broeders C.A. , Meijer Y. , Veerman A.J. , Touw I.P. , Lowenberg B.
Proc. Natl. Acad. Sci. U.S.A.91:4480-4484(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;POSSIBLE ASSOCIATION WITH SCN
9.

"Granulocyte colony-stimulating factor and its receptor in normal myeloid cell development, leukemia and related blood cell disorders."
Touw I.P. , van de Geijn G.J.
Front. Biosci.12:800-815(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
10.

"Clinical implications of ELA2-, HAX1-, and G-CSF-receptor (CSF3R) mutations in severe congenital neutropenia."
Zeidler C. , Germeshausen M. , Klein C. , Welte K.
Br. J. Haematol.144:459-467(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE ASSOCIATION WITH SCN
11.

"Solution structure of an extracellular domain containing the WSxWS motif of the granulocyte colony-stimulating factor receptor and its interaction with ligand."
Yamasaki K. , Naito S. , Anaguchi H. , Ohkubo T. , Ota Y.
Nat. Struct. Biol.4:498-504(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 227-334
12.

"Identification of a ligand-binding site on the granulocyte colony-stimulating factor receptor by molecular modeling and mutagenesis."
Layton J.E. , Iaria J. , Smith D.K. , Treutlein H.R.
J. Biol. Chem.272:29735-29741(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 125-331
13.

"Homodimeric cross-over structure of the human granulocyte colony-stimulating factor (GCSF) receptor signaling complex."
Tamada T. , Honjo E. , Maeda Y. , Okamoto T. , Ishibashi M. , Tokunaga M. , Kuroki R.
Proc. Natl. Acad. Sci. U.S.A.103:3135-3140(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 25-333 IN COMPLEX WITH CSF3;GLYCOSYLATION AT ASN-134;DISULFIDE BONDS;SUBUNIT
14.

"Novel point mutation in the extracellular domain of the granulocyte colony-stimulating factor (G-CSF) receptor in a case of severe congenital neutropenia hyporesponsive to G-CSF treatment."
Ward A.C. , van Aesch Y.M. , Gits J. , Schelen A.M. , de Koning J.P. , van Leeuwen D. , Freedman M.H. , Touw I.P.
J. Exp. Med.190:497-507(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-229;CHARACTERIZATION OF VARIANT HIS-229;POSSIBLE ASSOCIATION WITH SCN
15.

"An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia."
Plo I. , Zhang Y. , Le Couedic J.P. , Nakatake M. , Boulet J.M. , Itaya M. , Smith S.O. , Debili N. , Constantinescu S.N. , Vainchenker W. , Louache F. , de Botton S.
J. Exp. Med.206:1701-1707(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT NEUTROPHILIA ASN-640

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