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Index > Protein center > VCAN(Gene name) > Human
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  • VCAN (Gene name),
  • Versican core protein (Protein name ),  CSPG2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    VCAN(CSPG2);
    Protein name:
    Versican core protein;
    Alternative:
    Glial hyaluronate-binding protein(GHAP);Chondroitin sulfate proteoglycan core protein 2(Chondroitin sulfate proteoglycan 2);PG-M;Large fibroblast proteoglycan;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with FBLN1.
    Function:
    May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid.
    Subcellular Location:
    Secreted extracellular space extracellular matrix
    Protein Attributes:
    Sequence length:
    3396
    Sequence:
    50:
    MFINIKSILW | MCSTLIVTHA | LHKVKVGKSP | PVRGSLSGKV | SLPCHFSTMP | 
    100:
    TLPPSYNTSE | FLRIKWSKIE | VDKNGKDLKE | TTVLVAQNGN | IKIGQDYKGR | 
    150:
    VSVPTHPEAV | GDASLTVVKL | LASDAGLYRC | DVMYGIEDTQ | DTVSLTVDGV | 
    200:
    VFHYRAATSR | YTLNFEAAQK | ACLDVGAVIA | TPEQLFAAYE | DGFEQCDAGW | 
    250:
    LADQTVRYPI | RAPRVGCYGD | KMGKAGVRTY | GFRSPQETYD | VYCYVDHLDG | 
    300:
    DVFHLTVPSK | FTFEEAAKEC | ENQDARLATV | GELQAAWRNG | FDQCDYGWLS | 
    350:
    DASVRHPVTV | ARAQCGGGLL | GVRTLYRFEN | QTGFPPPDSR | FDAYCFKPKE | 
    400:
    ATTIDLSILA | ETASPSLSKE | PQMVSDRTTP | IIPLVDELPV | IPTEFPPVGN | 
    450:
    IVSFEQKATV | QPQAITDSLA | TKLPTPTGST | KKPWDMDDYS | PSASGPLGKL | 
    500:
    DISEIKEEVL | QSTTGVSHYA | TDSWDGVVED | KQTQESVTQI | EQIEVGPLVT | 
    550:
    SMEILKHIPS | KEFPVTETPL | VTARMILESK | TEKKMVSTVS | ELVTTGHYGF | 
    600:
    TLGEEDDEDR | TLTVGSDEST | LIFDQIPEVI | TVSKTSEDTI | HTHLEDLESV | 
    650:
    SASTTVSPLI | MPDNNGSSMD | DWEERQTSGR | ITEEFLGKYL | STTPFPSQHR | 
    700:
    TEIELFPYSG | DKILVEGIST | VIYPSLQTEM | THRRERTETL | IPEMRTDTYT | 
    750:
    DEIQEEITKS | PFMGKTEEEV | FSGMKLSTSL | SEPIHVTESS | VEMTKSFDFP | 
    800:
    TLITKLSAEP | TEVRDMEEDF | TATPGTTKYD | ENITTVLLAH | GTLSVEAATV | 
    850:
    SKWSWDEDNT | TSKPLESTEP | SASSKLPPAL | LTTVGMNGKD | KDIPSFTEDG | 
    900:
    ADEFTLIPDS | TQKQLEEVTD | EDIAAHGKFT | IRFQPTTSTG | IAEKSTLRDS | 
    950:
    TTEEKVPPIT | STEGQVYATM | EGSALGEVED | VDLSKPVSTV | PQFAHTSEVE | 
    1000:
    GLAFVSYSST | QEPTTYVDSS | HTIPLSVIPK | TDWGVLVPSV | PSEDEVLGEP | 
    1050:
    SQDILVIDQT | RLEATISPET | MRTTKITEGT | TQEEFPWKEQ | TAEKPVPALS | 
    1100:
    STAWTPKEAV | TPLDEQEGDG | SAYTVSEDEL | LTGSERVPVL | ETTPVGKIDH | 
    1150:
    SVSYPPGAVT | EHKVKTDEVV | TLTPRIGPKV | SLSPGPEQKY | ETEGSSTTGF | 
    1200:
    TSSLSPFSTH | ITQLMEETTT | EKTSLEDIDL | GSGLFEKPKA | TELIEFSTIK | 
    1250:
    VTVPSDITTA | FSSVDRLHTT | SAFKPSSAIT | KKPPLIDREP | GEETTSDMVI | 
    1300:
    IGESTSHVPP | TTLEDIVAKE | TETDIDREYF | TTSSPPATQP | TRPPTVEDKE | 
    1350:
    AFGPQALSTP | QPPASTKFHP | DINVYIIEVR | ENKTGRMSDL | SVIGHPIDSE | 
    1400:
    SKEDEPCSEE | TDPVHDLMAE | ILPEFPDIIE | IDLYHSEENE | EEEEECANAT | 
    1450:
    DVTTTPSVQY | INGKHLVTTV | PKDPEAAEAR | RGQFESVAPS | QNFSDSSESD | 
    1500:
    THPFVIAKTE | LSTAVQPNES | TETTESLEVT | WKPETYPETS | EHFSGGEPDV | 
    1550:
    FPTVPFHEEF | ESGTAKKGAE | SVTERDTEVG | HQAHEHTEPV | SLFPEESSGE | 
    1600:
    IAIDQESQKI | AFARATEVTF | GEEVEKSTSV | TYTPTIVPSS | ASAYVSEEEA | 
    1650:
    VTLIGNPWPD | DLLSTKESWV | EATPRQVVEL | SGSSSIPITE | GSGEAEEDED | 
    1700:
    TMFTMVTDLS | QRNTTDTLIT | LDTSRIITES | FFEVPATTIY | PVSEQPSAKV | 
    1750:
    VPTKFVSETD | TSEWISSTTV | EEKKRKEEEG | TTGTASTFEV | YSSTQRSDQL | 
    1800:
    ILPFELESPN | VATSSDSGTR | KSFMSLTTPT | QSEREMTDST | PVFTETNTLE | 
    1850:
    NLGAQTTEHS | SIHQPGVQEG | LTTLPRSPAS | VFMEQGSGEA | AADPETTTVS | 
    1900:
    SFSLNVEYAI | QAEKEVAGTL | SPHVETTFST | EPTGLVLSTV | MDRVVAENIT | 
    1950:
    QTSREIVISE | RLGEPNYGAE | IRGFSTGFPL | EEDFSGDFRE | YSTVSHPIAK | 
    2000:
    EETVMMEGSG | DAAFRDTQTS | PSTVPTSVHI | SHISDSEGPS | STMVSTSAFP | 
    2050:
    WEEFTSSAEG | SGEQLVTVSS | SVVPVLPSAV | QKFSGTASSI | IDEGLGEVGT | 
    2100:
    VNEIDRRSTI | LPTAEVEGTK | APVEKEEVKV | SGTVSTNFPQ | TIEPAKLWSR | 
    2150:
    QEVNPVRQEI | ESETTSEEQI | QEEKSFESPQ | NSPATEQTIF | DSQTFTETEL | 
    2200:
    KTTDYSVLTT | KKTYSDDKEM | KEEDTSLVNM | STPDPDANGL | ESYTTLPEAT | 
    2250:
    EKSHFFLATA | LVTESIPAEH | VVTDSPIKKE | ESTKHFPKGM | RPTIQESDTE | 
    2300:
    LLFSGLGSGE | EVLPTLPTES | VNFTEVEQIN | NTLYPHTSQV | ESTSSDKIED | 
    2350:
    FNRMENVAKE | VGPLVSQTDI | FEGSGSVTST | TLIEILSDTG | AEGPTVAPLP | 
    2400:
    FSTDIGHPQN | QTVRWAEEIQ | TSRPQTITEQ | DSNKNSSTAE | INETTTSSTD | 
    2450:
    FLARAYGFEM | AKEFVTSAPK | PSDLYYEPSG | EGSGEVDIVD | SFHTSATTQA | 
    2500:
    TRQESSTTFV | SDGSLEKHPE | VPSAKAVTAD | GFPTVSVMLP | LHSEQNKSSP | 
    2550:
    DPTSTLSNTV | SYERSTDGSF | QDRFREFEDS | TLKPNRKKPT | ENIIIDLDKE | 
    2600:
    DKDLILTITE | STILEILPEL | TSDKNTIIDI | DHTKPVYEDI | LGMQTDIDTE | 
    2650:
    VPSEPHDSND | ESNDDSTQVQ | EIYEAAVNLS | LTEETFEGSA | DVLASYTQAT | 
    2700:
    HDESMTYEDR | SQLDHMGFHF | TTGIPAPSTE | TELDVLLPTA | TSLPIPRKSA | 
    2750:
    TVIPEIEGIK | AEAKALDDMF | ESSTLSDGQA | IADQSEIIPT | LGQFERTQEE | 
    2800:
    YEDKKHAGPS | FQPEFSSGAE | EALVDHTPYL | SIATTHLMDQ | SVTEVPDVME | 
    2850:
    GSNPPYYTDT | TLAVSTFAKL | SSQTPSSPLT | IYSGSEASGH | TEIPQPSALP | 
    2900:
    GIDVGSSVMS | PQDSFKEIHV | NIEATFKPSS | EEYLHITEPP | SLSPDTKLEP | 
    2950:
    SEDDGKPELL | EEMEASPTEL | IAVEGTEILQ | DFQNKTDGQV | SGEAIKMFPT | 
    3000:
    IKTPEAGTVI | TTADEIELEG | ATQWPHSTSA | SATYGVEAGV | VPWLSPQTSE | 
    3050:
    RPTLSSSPEI | NPETQAALIR | GQDSTIAASE | QQVAARILDS | NDQATVNPVE | 
    3100:
    FNTEVATPPF | SLLETSNETD | FLIGINEESV | EGTAIYLPGP | DRCKMNPCLN | 
    3150:
    GGTCYPTETS | YVCTCVPGYS | GDQCELDFDE | CHSNPCRNGA | TCVDGFNTFR | 
    3200:
    CLCLPSYVGA | LCEQDTETCD | YGWHKFQGQC | YKYFAHRRTW | DAAERECRLQ | 
    3250:
    GAHLTSILSH | EEQMFVNRVG | HDYQWIGLND | KMFEHDFRWT | DGSTLQYENW | 
    3300:
    RPNQPDSFFS | AGEDCVVIIW | HENGQWNDVP | CNYHLTYTCK | KGTVACGQPP | 
    3350:
    VVENAKTFGK | MKPRYEINSL | IRYHCKDGFI | QRHLPTIRCL | GNGRWAIPKI | 
    3396:
    TCMNPSAYQR | TYSMKYFKNS | SSAKDNSINT | SKHDHRWSRR | WQESRR
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    MIM:
    KEGG:
    String:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Versican core protein
    Cat.:
    E1817h
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    MSDS:
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    96T
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    ELISA Kit for Human Versican core protein
    Cat.:
    E1817m
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    Packing:
    96T
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    ELISA Kit for Human Versican core protein
    Cat.:
    E1817r
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    Packing:
    96T
    ELISA Kit for Human Versican core protein
    Cat.:
    E1817b
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    Packing:
    96T
    ELISA Kit for Human Versican core protein
    Cat.:
    E1817c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Versican core protein
    Cat.:
    U1817r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Versican core protein
    Cat.:
    U1817b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Versican core protein
    Cat.:
    U1817m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Versican core protein
    Cat.:
    U1817c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Versican core protein
    Cat.:
    U1817h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human Versican core protein
    Polyclonal Antibody for Human Versican core protein
    Cat.:
    P1817Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Versican core protein
    Polyclonal Antibody for Human Versican core protein
    Cat.:
    P1817Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Versican core protein
    Cat.:
    P1817Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Versican core protein
    Monoclonal Antibody for Human Versican core protein
    Monoclonal Antibody for Human Versican core protein
    Monoclonal Antibody for Human Versican core protein
    Monoclonal Antibody for Human Versican core protein
    Protein for Human Versican core protein
    Protein for Human Versican core protein
    Protein for Human Versican core protein
    Protein for Human Versican core protein
    Protein for Human Versican core protein

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Multiple domains of the large fibroblast proteoglycan, versican."
      Zimmermann D.R. , Ruoslahti E.
      EMBO J.8:2975-2981(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM V1)
      tissue: Placenta.
    2. 2.
      "A novel glycosaminoglycan attachment domain identified in two alternative splice variants of human versican."
      Dours-Zimmermann M.T. , Zimmermann D.R.
      J. Biol. Chem.269:32992-32998(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM V2)
      tissue: Glial tumor.
    3. 3.
      "Characterization of the complete genomic structure of the human versican gene and functional analysis of its promoter."
      Naso M.F. , Zimmermann D.R. , Iozzo R.V.
      J. Biol. Chem.269:32999-33008(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM V0)
    4. 4.
      "Expression of PG-M(V3), an alternatively spliced form of PG-M without a chondroitin sulfate attachment in region in mouse and human tissues."
      Zako M. , Shinomura T. , Ujita M. , Ito K. , Kimata K.
      J. Biol. Chem.270:3914-3918(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM V3)
      tissue: Brain.
    5. 5.
      "Identification of the proteoglycan versican in aorta and smooth muscle cells by DNA sequence analysis, in situ hybridization and immunohistochemistry."
      Yao L.Y. , Moody C. , Schoenherr E. , Wight T.N. , Sandell L.J.
      Matrix Biol.14:213-225(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 208-1427; 2081-2372 AND 2897-3233 (ISOFORM V1)
    6. 6.
      "Mapping of the versican proteoglycan gene (CSPG2) to the long arm of human chromosome 5 (5q12-5q14)."
      Iozzo R.V. , Naso M.F. , Cannizzaro L.A. , Wasmuth J.J. , McPherson J.D.
      Genomics14:845-851(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 251-347
    7. 7.
      "A fibroblast chondroitin sulfate proteoglycan core protein contains lectin-like and growth factor-like sequences."
      Krusius T. , Gehlsen K.R. , Ruoslahti E.
      J. Biol. Chem.262:13120-13125(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2709-3396
      tissue: Lung fibroblast.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3333-3396 (ISOFORM VINT)
      tissue: Aortic smooth muscle.
    9. 9.
      "Isolation of a large aggregating proteoglycan from human brain."
      Perides G. , Rahemtulla F. , Lane W.S. , Asher R.A. , Bignami A.
      J. Biol. Chem.267:23883-23887(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-37
    10. 10.
      "Isolation and partial characterization of a glial hyaluronate-binding protein."
      Perides G. , Lane W.S. , Andrews D. , Dahl D. , Bignami A.
      J. Biol. Chem.264:5981-5987(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 24-50; 80-119; 128-155; 167-218; 229-268 AND 277-290
      tissue: Brain.
    11. 11.
      "Structural similarity of hyaluronate binding proteins in brain and cartilage."
      Bignami A. , Lane W.S. , Andrews D. , Dahl D.
      Brain Res. Bull.22:67-70(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 171-210 AND 289-303
    12. 12.
      "Differential expression of versican isoforms in brain tumors."
      Paulus W. , Baur I. , Dours-Zimmermann M.T. , Zimmermann D.R.
      J. Neuropathol. Exp. Neurol.55:528-533(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY (ISOFORMS V0; V1; V2 AND V3)
    13. 13.
      "Identification of a novel splice site mutation of the CSPG2 gene in a Japanese family with Wagner syndrome."
      Miyamoto T. , Inoue H. , Sakamoto Y. , Kudo E. , Naito T. , Mikawa T. , Mikawa Y. , Isashiki Y. , Osabe D. , Shinohara S. , Shiota H. , Itakura M.
      Invest. Ophthalmol. Vis. Sci.46:2726-2735(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN WGVRP
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Novel VCAN mutations and evidence for unbalanced alternative splicing in the pathogenesis of Wagner syndrome."
      Kloeckener-Gruissem B. , Neidhardt J. , Magyar I. , Plauchu H. , Zech J.C. , Morle L. , Palmer-Smith S.M. , Macdonald M.J. , Nas V. , Fry A.E. , Berger W.
      Eur. J. Hum. Genet.21:352-356(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN WGVRP;PATHOLOGICAL MECHANISM
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