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Index > Protein center > CSPG4(Gene name) > Human
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  • CSPG4 (Gene name),
  • Chondroitin sulfate proteoglycan 4 (Protein name ),  CSPG4_HUMAN from NCBI database.
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  • General Annotation
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  • Gene name:
    CSPG4(MCSP);
    Protein name:
    Chondroitin sulfate proteoglycan 4;
    Alternative:
    Melanoma chondroitin sulfate proteoglycan;Chondroitin sulfate proteoglycan NG2;Melanoma-associated chondroitin sulfate proteoglycan;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with the first PDZ domain of MPDZ. Interacts with PRKCA. Binds TNC, laminin-1, COL5A1 and COL6A2. Interacts with PLG and angiostatin. Binds FGF2 and PDGFA. Interacts with GRIP1, GRIP2 and GRIA2. Forms a ternary complex with GRIP1 and GRIA2 (By similarity). Interacts with LGALS3 and the integrin composed of ITGB1 and ITGA3. Interacts with ITGA4 through its chondroitin sulfate glycosaminoglycan. Interacts with BCAR1, CDC42 and ACK1. Interacts with MMP16.
    Function:
    Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Functions also as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
    Subcellular Location:
    Apical cell membrane Single-pass type I membrane protein Extracellular side Cell projection lamellipodium membrane Single-pass type I membrane protein Extracellular side Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. Localizes to the plasma membrane of oligodendrocytes.
    Protein Attributes:
    Sequence length:
    2322
    Sequence:
    50:
    MQSGPRPPLP | APGLALALTL | TMLARLASAA | SFFGENHLEV | PVATALTDID | 
    100:
    LQLQFSTSQP | EALLLLAAGP | ADHLLLQLYS | GRLQVRLVLG | QEELRLQTPA | 
    150:
    ETLLSDSIPH | TVVLTVVEGW | ATLSVDGFLN | ASSAVPGAPL | EVPYGLFVGG | 
    200:
    TGTLGLPYLR | GTSRPLRGCL | HAATLNGRSL | LRPLTPDVHE | GCAEEFSASD | 
    250:
    DVALGFSGPH | SLAAFPAWGT | QDEGTLEFTL | TTQSRQAPLA | FQAGGRRGDF | 
    300:
    IYVDIFEGHL | RAVVEKGQGT | VLLHNSVPVA | DGQPHEVSVH | INAHRLEISV | 
    350:
    DQYPTHTSNR | GVLSYLEPRG | SLLLGGLDAE | ASRHLQEHRL | GLTPEATNAS | 
    400:
    LLGCMEDLSV | NGQRRGLREA | LLTRNMAAGC | RLEEEEYEDD | AYGHYEAFST | 
    450:
    LAPEAWPAME | LPEPCVPEPG | LPPVFANFTQ | LLTISPLVVA | EGGTAWLEWR | 
    500:
    HVQPTLDLME | AELRKSQVLF | SVTRGARHGE | LELDIPGAQA | RKMFTLLDVV | 
    550:
    NRKARFIHDG | SEDTSDQLVL | EVSVTARVPM | PSCLRRGQTY | LLPIQVNPVN | 
    600:
    DPPHIIFPHG | SLMVILEHTQ | KPLGPEVFQA | YDPDSACEGL | TFQVLGTSSG | 
    650:
    LPVERRDQPG | EPATEFSCRE | LEAGSLVYVH | RGGPAQDLTF | RVSDGLQASP | 
    700:
    PATLKVVAIR | PAIQIHRSTG | LRLAQGSAMP | ILPANLSVET | NAVGQDVSVL | 
    750:
    FRVTGALQFG | ELQKQGAGGV | EGAEWWATQA | FHQRDVEQGR | VRYLSTDPQH | 
    800:
    HAYDTVENLA | LEVQVGQEIL | SNLSFPVTIQ | RATVWMLRLE | PLHTQNTQQE | 
    850:
    TLTTAHLEAT | LEEAGPSPPT | FHYEVVQAPR | KGNLQLQGTR | LSDGQGFTQD | 
    900:
    DIQAGRVTYG | ATARASEAVE | DTFRFRVTAP | PYFSPLYTFP | IHIGGDPDAP | 
    950:
    VLTNVLLVVP | EGGEGVLSAD | HLFVKSLNSA | SYLYEVMERP | RHGRLAWRGT | 
    1000:
    QDKTTMVTSF | TNEDLLRGRL | VYQHDDSETT | EDDIPFVATR | QGESSGDMAW | 
    1050:
    EEVRGVFRVA | IQPVNDHAPV | QTISRIFHVA | RGGRRLLTTD | DVAFSDADSG | 
    1100:
    FADAQLVLTR | KDLLFGSIVA | VDEPTRPIYR | FTQEDLRKRR | VLFVHSGADR | 
    1150:
    GWIQLQVSDG | QHQATALLEV | QASEPYLRVA | NGSSLVVPQG | GQGTIDTAVL | 
    1200:
    HLDTNLDIRS | GDEVHYHVTA | GPRWGQLVRA | GQPATAFSQQ | DLLDGAVLYS | 
    1250:
    HNGSLSPRDT | MAFSVEAGPV | HTDATLQVTI | ALEGPLAPLK | LVRHKKIYVF | 
    1300:
    QGEAAEIRRD | QLEAAQEAVP | PADIVFSVKS | PPSAGYLVMV | SRGALADEPP | 
    1350:
    SLDPVQSFSQ | EAVDTGRVLY | LHSRPEAWSD | AFSLDVASGL | GAPLEGVLVE | 
    1400:
    LEVLPAAIPL | EAQNFSVPEG | GSLTLAPPLL | RVSGPYFPTL | LGLSLQVLEP | 
    1450:
    PQHGALQKED | GPQARTLSAF | SWRMVEEQLI | RYVHDGSETL | TDSFVLMANA | 
    1500:
    SEMDRQSHPV | AFTVTVLPVN | DQPPILTTNT | GLQMWEGATA | PIPAEALRST | 
    1550:
    DGDSGSEDLV | YTIEQPSNGR | VVLRGAPGTE | VRSFTQAQLD | GGLVLFSHRG | 
    1600:
    TLDGGFRFRL | SDGEHTSPGH | FFRVTAQKQV | LLSLKGSQTL | TVCPGSVQPL | 
    1650:
    SSQTLRASSS | AGTDPQLLLY | RVVRGPQLGR | LFHAQQDSTG | EALVNFTQAE | 
    1700:
    VYAGNILYEH | EMPPEPFWEA | HDTLELQLSS | PPARDVAATL | AVAVSFEAAC | 
    1750:
    PQRPSHLWKN | KGLWVPEGQR | ARITVAALDA | SNLLASVPSP | QRSEHDVLFQ | 
    1800:
    VTQFPSRGQL | LVSEEPLHAG | QPHFLQSQLA | AGQLVYAHGG | GGTQQDGFHF | 
    1850:
    RAHLQGPAGA | SVAGPQTSEA | FAITVRDVNE | RPPQPQASVP | LRLTRGSRAP | 
    1900:
    ISRAQLSVVD | PDSAPGEIEY | EVQRAPHNGF | LSLVGGGLGP | VTRFTQADVD | 
    1950:
    SGRLAFVANG | SSVAGIFQLS | MSDGASPPLP | MSLAVDILPS | AIEVQLRAPL | 
    2000:
    EVPQALGRSS | LSQQQLRVVS | DREEPEAAYR | LIQGPQYGHL | LVGGRPTSAF | 
    2050:
    SQFQIDQGEV | VFAFTNFSSS | HDHFRVLALA | RGVNASAVVN | VTVRALLHVW | 
    2100:
    AGGPWPQGAT | LRLDPTVLDA | GELANRTGSV | PRFRLLEGPR | HGRVVRVPRA | 
    2150:
    RTEPGGSQLV | EQFTQQDLED | GRLGLEVGRP | EGRAPGPAGD | SLTLELWAQG | 
    2200:
    VPPAVASLDF | ATEPYNAARP | YSVALLSVPE | AARTEAGKPE | SSTPTGEPGP | 
    2250:
    MASSPEPAVA | KGGFLSFLEA | NMFSVIIPMC | LVLLLLALIL | PLLFYLRKRN | 
    2300:
    KTGKHDVQVL | TAKPRNGLAG | DTETFRKVEP | GQAIPLTAVP | GQGPPPGGQP | 
    2322:
    DPELLQFCRT | PNPALKNGQY | WV
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    UniGene:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Chondroitin sulfate proteoglycan 4
    Cat.:
    E2136h
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    Packing:
    96T
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    ELISA Kit for Human Chondroitin sulfate proteoglycan 4
    Cat.:
    E2136m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Chondroitin sulfate proteoglycan 4
    Cat.:
    E2136r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    CLIA Kit for Human Chondroitin sulfate proteoglycan 4
    Cat.:
    U2136h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Chondroitin sulfate proteoglycan 4
    Cat.:
    U2136m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Chondroitin sulfate proteoglycan 4
    Cat.:
    U2136r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Chondroitin sulfate proteoglycan 4
    Cat.:
    P2136Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Chondroitin sulfate proteoglycan 4
    Cat.:
    P2136Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Chondroitin sulfate proteoglycan 4
    Cat.:
    P2136Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Chondroitin sulfate proteoglycan 4
    Monoclonal Antibody for Human Chondroitin sulfate proteoglycan 4
    Monoclonal Antibody for Human Chondroitin sulfate proteoglycan 4
    Protein for Human Chondroitin sulfate proteoglycan 4
    Protein for Human Chondroitin sulfate proteoglycan 4
    Protein for Human Chondroitin sulfate proteoglycan 4

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    s
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
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    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    Saliva(n=3)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan."
      Pluschke G. , Vanek M. , Evans A. , Dittmar T. , Schmid P. , Itin P. , Filardo E.J. , Reisfeld R.A.
      Proc. Natl. Acad. Sci. U.S.A.93:9710-9715(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
      tissue: Melanoma.
    2. 2.
      "Melanoma chondroitin sulfate proteoglycan enhances FAK and ERK activation by distinct mechanisms."
      Yang J. , Price M.A. , Neudauer C.L. , Wilson C. , Ferrone S. , Xia H. , Iida J. , Simpson M.A. , McCarthy J.B.
      J. Cell Biol.165:881-891(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION
      tissue: Melanoma.
    3. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 5.
      "A role of chondroitin sulfate glycosaminoglycan binding site in alpha4beta1 integrin-mediated melanoma cell adhesion."
      Iida J. , Meijne A.M.L. , Oegema T.R. Jr. , Yednock T.A. , Kovach N.L. , Furcht L.T. , McCarthy J.B.
      J. Biol. Chem.273:5955-5962(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITGA4
    5. 6.
      "Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas."
      Eisenmann K.M. , McCarthy J.B. , Simpson M.A. , Keely P.J. , Guan J.-L. , Tachibana K. , Lim L. , Manser E. , Furcht L.T. , Iida J.
      Nat. Cell Biol.1:507-513(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCAR1; CDC42 AND ACK1;FUNCTION
    6. 7.
      "Melanoma chondroitin sulfate proteoglycan regulates matrix metalloproteinase-dependent human melanoma invasion into type I collagen."
      Iida J. , Pei D. , Kang T. , Simpson M.A. , Herlyn M. , Furcht L.T. , McCarthy J.B.
      J. Biol. Chem.276:18786-18794(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MMP16;FUNCTION
    7. 8.
      "A novel repeat in the melanoma-associated chondroitin sulfate proteoglycan defines a new protein family."
      Staub E. , Hinzmann B. , Rosenthal A.
      FEBS Lett.527:114-118(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION OF CSPG REPEATS
    8. 9.
      "NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin."
      Fukushi J. , Makagiansar I.T. , Stallcup W.B.
      Mol. Biol. Cell15:3580-3590(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ITGA3; ITGB1 AND LGALS3
    9. 10.
      "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
      J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-2075
      tissue: Plasma.
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